{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022sBPukldvA4uHbyTNnjYrTN2qdQIlPTQ6rPJ+K+I1Fl2pQJAxw1EMqlgF0yMDqSsfNbrQKq5jcPjwAZsangwrpo0ceq\\\\\\\\\\\\\\\/Fq8tkT8FpdH7bO41m6jGFX49doqCajuNTn9LHDf4MqSTf2IaTF7Om0+74sprNUzIH\\\\\\\\\\\\\\\/C1VaEp7F1pDpptdcICCvaIWDO41UCb9gf+gCAsFPTdCKpgUEEA1N2m4BbW226uweZey\\\\\\\\\\\\\\\/hlRzNBWjV0YBZuxvaaESPPY5zRjR8PLobpCx8AO2rB+KBp9aKrPr3OGYTZamqNvWfciMOEBYhm3mgEyPBlVr+9uCF+vUID3dDx2TTptnq96HWn551G2\\\\\\\\\\\\\\\/Q3mxEOaeeija\\\\\\\\\\\\\\\/X0sT\\\\\\\\\\\\\\\/SmscgtHzpnbF6Dzv4Ucr5tjB4KVSHkYY+0Iw8oPXBeSZ33li5+mcbrC5a0\\\\\\\\\\\\\\\/rM557SApO3mRjkk61L3iiEWCaUDy4FjTXbxcybhRDE6NmaVzmMwI5l3g7MhnAK8aiXru1JWEJdeuLdiTBBltu7lT1xWE2UvIi3NBtHa5lCcOo2WstuVMnmAW16+6DtmL7fLb+djmcIKWsOOwLee+Gia5xO\\\\\\\\\\\\\\\/Ea89O8YH46MNtes3lhnL0D5Al5P2xMvRov1c4P\\\\\\\\\\\\\\\/XITyilmP8oLM9D8F66k\\\\\\\\\\\\\\\/+lyIPUXHWXuQc64MSuCIWVz16tEZgLqjqgfZB4jbG7TSBT3OfqxauYgJq+sUMgKm3dGCLF+Ixlq8hBoBO\\\\\\\\\\\\\\\/rRpHhhrnuS\\\\\\\\\\\\\\\/j9jtot83UPA3RENWOK3uH7c1ba96CGdIR7+PoOu5t+ksInOxrUHaZBiIF0Rjf\\\\\\\\\\\\\\\/k5YrRo8GOihxMhCrPZS\\\\\\\\\\\\\\\/Nzk9IusW6Jykroxhmc4bWFQQKz1ry4+Ke\\\\\\\\\\\\\\\/Eb4lSQuh8tKMMjGoz6+kOk+56mImdCv1kzmfj83bRaevYU24p2GJK4PcftOr3iMeQJ7V8v+PnxA5G+7lyNIXJQlsqn1XlV5nlrLofsSOrgMT+q9b0A+i5EpTEBBjrrRe\\\\\\\\\\\\\\\/Ky\\\\\\\\\\\\\\\/hOmPd2I3XNJ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/qCbLYozWkfgJyuuvj4pPdV+eqjiFc4YCnndz7pvQ01r4qJMCnJvBfZ8+9IsB2zv9PPQFRPRj8hTf4weB\\\\\\\\\\\\\\\/9UCnAC\\\\\\\\\\\\\\\/HwLOX5Ea8CoKyvTQ9UE9lEMN3RfCl2PaWhjY0I+PEfbON9wCiUMiXjQmnpxX8kov3++5kl+pxeext1GO+8NpumFQLhLvwvTJ8awlKgW2L0j4d0HjdNf2fqgbsmIdLdahky6t4ASlgfTsC5hyOSAujUQE6txQWVSG87FKXDXrwdXe6Uupbl7ebe+O8Pn8GB5kRHpVmg4N4iCLwkUYlZ2Y8ytQwNObk1Ua7HUnwaD0b6vs4lSC1HwevxAvBxKAov+VDeWlTFxgt1kWp+H0AZaIMORZCFfE+s70r79RqunYok\\\\\\\\\\\\\\\/vzAlI2vRkRK25BNlrIdv4LF5+SoSm4qHuwoHfRDaCr6ZzOGW2OhPzp2i6s6UW\\\\\\\\\\\\\\\/pBryUkaEy9lF\\\\\\\\\\\\\\\/XL+4SYlN6B7ZuutVVF1QBEK+m9uA1qbDUtusXg8qLYPDiPsc+PCDBIybnvfmVEZvQGnJoVaepV1RHgPuFZb6pbScWdhykBMnobtLI1kFhsOQ0xcRtQms+GgSoVgF3cr9FF\\\\\\\\\\\\\\\/TAEKj97DZdPDb\\\\\\\\\\\\\\\/ibx5nqJzlfxGV8K2dORB1CbNH5GbsrFr0hv7DwK+GJ4WwExaqK+xsY8GTOxYK9TKjjMyPkregRrkcpULPS1gEkL2dMmYu8EX5U+Ulfqe5Mc\\\\\\\\\\\\\\\/AF5S4eAQfdaxUSL\\\\\\\\\\\\\\\/TW85aiDuLjkB5Wcc\\\\\\\\\\\\\\\/bR8xhAXI2Yh7sKTZaOgI8svWdNBu5CfC2Ug76FdL6kwd4qFeeDF+so423Ce5+8hVmYcLUoHf5IXpBKLXn5wlw7FDa+zsXgfrPG4vnOP9FThioM0\\\\\\\\\\\\\\\/7IM3m0TAF0tcU00iAVZAFtoiMHbnvEy7ePSAntLn5YXGcLcr5Um+B4MkrbT1Vt6cZMyjLXRLMZCFicdEbDqw6afN\\\\\\\\\\\\\\\/udXeVHQTgKcc1lkLQ0\\\\\\\\\\\\\\\/tTSYil5Fiai45rf\\\\\\\\\\\\\\\/cuOvEgb3IEOnj0OpOuQfJ3QlFfbjfLlO\\\\\\\\\\\\\\\/TjqsOwyCv\\\\\\\\\\\\\\\/QprwlI4Nbvu\\\\\\\\\\\\\\\/eDUWnXUmMGgVW4XviYZjA76b2C9ZGZl\\\\\\\\\\\\\\\/v1I5LNpaO8zPe+hm13Szw2ln1iz9z1X63UOufp9s\\\\\\\\\\\\\\\/uUnYDcBumYbZf\\\\\\\\\\\\\\\/bDQRpngjju61Xyy+0yJwcMj5OqVt0WM9pFbkdYNJ+n+++Any9K0q9lASCXtMUdnx0ufqyc341mffsXpIUh+RxkqGhDawFw6mxI\\\\\\\\\\\\\\\/IZRcGfktU6n9wAqzlaNfG1PsuMeqWUusUiMQ4fSJQJBepJe2pWYQNXc0swDvBdz\\\\\\\\\\\\\\\/JHUI2QIR94dbtJak93XIRZNdVfLl+y+N7hM5cFqtVTljNnUWYuEYxPGKljxeXu9fAOjDCkJhn53XtbYrQyZSUspvRuWdoF0ToBi1n9k1t4OIBHUMKMwEuB99Tvexh3wWPBPEm5FyiWNvHE47C2IiFjp4R6TszqJWRRa7bPFzaoLPLGGMjf287lORNxzq08ua+JkKtrNwTsWQiZRdRF2E2V9Q\\\\\\\\\\\\\\\/aq+ZwBdp0A8tEfVEsVMFUG4\\\\\\\\\\\\\\\/3GY7taDKOEZpeFufDg5sMNoIkbyHe2z\\\\\\\\\\\\\\\/RW8iY3BZyy4sSVzJd9xIJzgdgaRpTzJVol\\\\\\\\\\\\\\\/8Tnz41u1jS3xMPu6d3js=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022VCFBRGjytMVbgbNOajOlVg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022defb67366aebe980c2526e75ae24587d4e91046d2066d5e0a35aa5a0c41569ae\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/3\\\/e003721.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/3\\\/e003721.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003721\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003721\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003721\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}