{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022O9Lq9CxJeQBcOUeGDPOvc8yvNJvXNvSagzC1\\\\\\\\\\\\\\\/lTVVG4j728WyrHoLFc8aXFf7rTXBbcCc18sweUM\\\\\\\\\\\\\\\/mChMXHaLNY3dxMFL2ZKUyL9EFg9+g3CxZpyyza+DVIB7PGqMNOR81yn3UTdkqpYNdJ0j9AyZwKyGvJqFaPCm6sqW+d8ffmLNQiMl1IEMWT4ALtdMePQVmt8Mb8zHx2AVCLXmlQsJd0PWAIGU88HnvEjHlBzz6EQaVsmQonOiLud+lO6itTsmXHBWGgHH1QoseHdGecf\\\\\\\\\\\\\\\/p3k3O0G1gmZuh9r2aYT3LVIB1gyHLMvA9tJdCweX\\\\\\\\\\\\\\\/8Jem5mIuY1adQJSow8cWF5i52wzGbfVdfASWzKP7v\\\\\\\\\\\\\\\/i94l0TRA6ZOJQuifq0\\\\\\\\\\\\\\\/PqDXQ6NHIhKKdngarLBhxcxEqZXyOCAD69G7UpkfQ8h\\\\\\\\\\\\\\\/saM30zpTyLO65Ep600OeTynleBEc3eHRBjPNYyCUDU\\\\\\\\\\\\\\\/CL3MrexCG+6D7I04ux2Uvlb6r6DU2NH3AndAIGPz6bXojUUvlVWggE8a83Pym3uG2Ph7lENuUlRNTer7OimJzw6meZt04WwOKsidQe97JuJqMvSASRFpnt4sxmerNYJ0JqyidjbFxj\\\\\\\\\\\\\\\/33oBzHDxVGCEzxXa5GGvXpJG4vIdzz0dnCHXgJRGUnVNP6eeSfKu0Cp+VPv9UP0XO11AM6mmkOabpz7lqIbQuoLOSfLuSoMpn1a0qsl8V1TwKy+ogccMaRcy8R\\\\\\\\\\\\\\\/d4bU4yUsTFZb+5EtoOgEGmYz8yQ9L\\\\\\\\\\\\\\\/MSWaLc1K4OfEb9dmcNYzPf0s6CCn2uCKZ5sut+03WuJZRIDtm8EdQvKDziwaAZfINvBjf8OAjczAU3m8LaShh0eRHuahSNPbv8DWW+d1NhkrBP0uHWABDbSBFZfFe92EBEULslxsdDqOyxcmprefCeNRX+RaOaphtzbWvi266cchMGKJVpDgsU5zPsSke\\\\\\\\\\\\\\\/CFE67cATqIuazlwo77+tN61YhCQf+2AR9zzNJ8c+jy87ZGE+SB+Ad2dJXG64OHUSxtYDGHqXaxZOAypGqeIkuMGLYMTgv\\\\\\\\\\\\\\\/0kKBgRKJfadGceHf4lgCVfPZgNeZUtndTiq3zYrjqdk+wsQDOlSCIktK2Ms4Qzq4J\\\\\\\\\\\\\\\/WzerIlt4UsebmA4HUduo1KnPWzcSZocHVnbp2ctxpnM5q6Mqf7+SXXcnd+5Zbk1svoQpI2wU9TkZzYh4CoBj4wLHF3YIrjttTROSf89R6Qx4L6KcXW1XPUKUE7AK3EEex+WhtyeLmzQwZ7tjPOgZ0eJ5TqL7EJ3ZV2G8nPGvDe8EQoXjYKVgZEElRUlukkqE5WDJj2GqYK7MqKOnbVXlYbSOLkgBGPJ\\\\\\\\\\\\\\\/FnFdqmom0z+1+mp13l4Cdq2kTtLw0L0twgcV6M3ZaSRzV2MotTl6H9OJ+c4eq309l6T51twm1fVmhh1bPhGSWqSs5se95+kkge39jDnJxfWrlNi6qn+Np0JxmPfVkFg31VMM5RnW1KTtxeQ7rT310PD+hxY\\\\\\\\\\\\\\\/L7NflhiPH9\\\\\\\\\\\\\\\/f0dhqCAYTrKJATAcSep8cisXabzv7nSbeQC+jf8BFmONzmjXbA0Sba1LxYvrhY+olA5gU3KaFlVWwXP4vhoNGXJ14xLbK4vrEV8y3jdYaJADoHhfUeLAFROXI5qZIhfH9UoP9Zm43jHnwOWa78dY3Fdf97CSqeZ9ny5wBJqLu9gBsEBD48HBVpGwK6kVXWW2efHOqIrwF9LnBt3mTPHc7l\\\\\\\\\\\\\\\/R2SdF+adveO+6fQ6poo1kUxjmxxG1PLEOKV86m5nYyGG20+qG4AaSg216rsBMmf+9PjCCJ41XrioeK15NxiVChjBmkmQQ0UxjNamK4AhahSnj024rNPLz7fup5P8rht8RWQDfElZbvalcaG0YnKSABAmdOyH+2cFC1FOTK+d51TipjCpryhaWL5sKu0RheFFWc26\\\\\\\\\\\\\\\/DPla9PYec\\\\\\\\\\\\\\\/EhM2ZE0MpYwLlW9\\\\\\\\\\\\\\\/w74ldOJoUTj2GL2FBs37\\\\\\\\\\\\\\\/17JH\\\\\\\\\\\\\\\/9FSqRGXWd9BwzfJZNTnnejkvVwDkD\\\\\\\\\\\\\\\/zAFLWmOh58V1lQeKqauOxXVOTcJKkcXv91u5QUozexf6SRZ6W+NYfSR5Q23RQ7uSHaZME5HhaCseibaHxcUIqQE3okmArYVZUxJUrSfbsvRvBeYUUGN3CJLhD\\\\\\\\\\\\\\\/4QUSRNBeqAnN1fn0ZwW9XuQX6eDUG61uY0egCXSg8vc+7GX28h3mgqpf0aIumgy8vUmTdUFP2XKZvJHp\\\\\\\\\\\\\\\/83d5FnS+WxPofMXw4bbG6yBko3cz5zS8ZNkBlFAe6NXaq5VRTG8GPcFrcGbpVN+qCBQa7xR+GjCvumbs9zakag05pqxRRLK8BFGn5tScay2ph3pWjEPDn\\\\\\\\\\\\\\\/Ekull2eY8iRVxnPiLZdjwiTR1bF8hIbpTBULWRaGAOfVCrXlfquOOO3SzpN+ifOjDpFcvBb9gdda8V9KtbjVvR6u0RD8M16DlYoGmotTgVAYZ9aZiD7RgKxwceOT4xB9HgqFM9SvQTao+NFMF8ofNtGJrezOz5QrH8YTdZEqn9fckXzA4tIw68PR\\\\\\\\\\\\\\\/Np8GozA+18Pkx0K5321n191AVJAkYbpyTwL2Y3x52QL+YzAZR4EGXdxuW91u60btVpQZip28GrGtYAkXjJqjV4ZbAtMSyUrioj4JBSX4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022DjbMJ6Mm\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/4sAX2k29PKw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a273dc07bad97298fcece3fb1896426ea09e72cd63a8fe350aba43d73261e13b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/3\\\/e003255.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/3\\\/e003255.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003255\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003255\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003255\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}