{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Y\\\\\\\\\\\\\\\/fPScav0W1uTTVBl50AQwt0GnviNhzZJmm0wTAeDf\\\\\\\\\\\\\\\/XcLNSTxPQU4Jp24xDvbpYRm0AVSwqrfnGuM6Q62\\\\\\\\\\\\\\\/3nCEO5K5fV8rczCOXCYMY0e9AM7mBoHzD2CJjTd0Aed+Blx3Ca31F3KsP2mulFhcZsGqMRobua2ns6eWB03PT6KDYynW+Sxy5s2xJkRBO6pp5yCpzVovZnKPXHcG08dYJNer7xRfTjpHFFOaxpFWS7NTq5lI6sqPI+BotIhed6KiFPpFY1Q7bjNAZuX2t7HTI2fqvXxWVp+cOjcWOG8l3iLmMaSjG37VdEQM26pRP8mXWLRD8ZUSs8uEePUsQ5Q+uvN7MGh+koK1S+PjmY\\\\\\\\\\\\\\\/lWJ6lF1LvaUUIoqjPKokyuOG3cU+kASRKFNnSFC4fMGv2uelUXI5\\\\\\\\\\\\\\\/crErR+tbN54FwvQnuPXDOlbuGdGRc02BWi8b2uTIfslxnxO5rgKXhhcPVcLavMSTk1V5cgB2XPQyThCD6tsRWsF8Yhc+TZrnz7i0Mi+qI5FdJEykXovHOpw3CXnUdkEtDmGU+6fCb+83doaaQFH1yaYMKEQK3l8OJIu7WHKD+Ynbd68w0eilaRXeYOOWt1ELl1O0z0amSca6ol40hT\\\\\\\\\\\\\\\/gj36RO+qjbeytfBul1kLLOeWQgGKjqFiF4Odat+669ggORha8PhOCBqQBWR3fcqUFJ4Dl1ktFKrJ2vnfPFoxxendp9Yb1XyFqGsUD73AddobbPueXdUKRzNZmkdFjkpS3AhvZ2dDwu9m+gs9XHyT3ZB8tK4WmFBKy7ULmQUjNQYLWHffpwYlVbiZG2GEtBpDxw\\\\\\\\\\\\\\\/Cqy91Dd0v4Xk\\\\\\\\\\\\\\\/lIOfGOn4YB+XZMpMnYxNo9gAYlNMN9kb9vrfrkGyxw0uOtcSH6K1lYr5P2t5\\\\\\\\\\\\\\\/7NUGVWn9G7MMHoX8rBIocvFP4iNPKvdoeRMo7s6t95rnK4HKzF8CmvIDdHS0oEaazr25ESPYtOTUDT5+hvEEtd801C52WFp22fLCnvveC2IhYyTOUAY6YT0jOIimid8suMmKMquwsYP1gih2qW7gvTHA\\\\\\\\\\\\\\\/6rq9\\\\\\\\\\\\\\\/DWvkW5K6T5XiyTPQ5VyTHTZ6ASR5CuFXD3usGvbTBwkYq6AbjhBmxfMopU0mNhmZLmH8aY\\\\\\\\\\\\\\\/B+zmLY\\\\\\\\\\\\\\\/ly6p97SRGY2x7XEQRMCzr+8urK8FJrPPVDZ2yhXXhTDt+O6H3vy4INPVSgZwfZKgf9DKVCdjGHbEfYj7begHjOqYZc+gJIghCj\\\\\\\\\\\\\\\/bVeX8gT\\\\\\\\\\\\\\\/cslmRzaJSeu\\\\\\\\\\\\\\\/Wg58PFret4HnERDqtB+nBmvOZR1tVIN5WLM6YWPiEFMX3Md8qodezhHj7Xq67Nvfzv09cHTtmSDpmJK84eP6UepvbI0yzDQpCbcVoJVQPJdby1yRcGcIaAaUHBqtVuR1PT\\\\\\\\\\\\\\\/aLMbFDBU\\\\\\\\\\\\\\\/POagADFQEOOyMDdQrL9j7\\\\\\\\\\\\\\\/i8P8hlZFmIe3sye3ItTYj9B2lcJL68UtvcelZ4Y2rdqqJbR\\\\\\\\\\\\\\\/f\\\\\\\\\\\\\\\/V08izT4mxTxjBoeHRW+DzWKtf8BzWLXHXc6LaMBJ8vJTSVK4tb7Bk8btTyxIhfLzDxW7FL1zP0NnZOJAVlIYiRMGFQf9za7jlrcAB7Cnmp81dbeOf5zSfAv4X4V6WkCctosU3hvCHDw+ukmJhOPoXg+bpDgv9ZjGLp\\\\\\\\\\\\\\\/3NcXZ3pNIpuwC2alemHvSySZqVceCAmHA0X6iH0Fvxwg6EhhuprZAs4653yaH+BQjdSf+EyBsDx3Xpm4WBBa7u7WTMKohLr\\\\\\\\\\\\\\\/RKJnH\\\\\\\\\\\\\\\/dC0gxgTrPMCOlonfTAcsk177g61fhgZoH3JbSIZ6x3AOxVrdvLMoVyIReNZ6lsSX+smThwbOIBhThSTjsCrsMhVzeuI72qMUVCQCmiJPesFUr39mge77cjIxfGLnQQh2Rnll2i3TU3cpdAIFOnCRMyJWwc1ASZmk7NwWvjhWseK7e\\\\\\\\\\\\\\\/mpriEyfThO8Tmp8\\\\\\\\\\\\\\\/gYFkx5+6ZmgCzin0vlVf3W9Cmxs\\\\\\\\\\\\\\\/3WDyVHtWtJ2azk9mF2eA7kZvRQFM7XyqT0uxfaMfd173xaCoTgGC5pF7wwGgudupl\\\\\\\\\\\\\\\/idHpnj5HrrZjhPosTVB4SScvk6BQDbkIjeVgydOuFsDZYvUm9QlGsaTTlrdgMQJ9sN9Pc3\\\\\\\\\\\\\\\/2jdjTYPC7vMbLVkxiVEdlVUzupfMaPDqtCF1KtKs9tEncDlq6UZslCfCDuMapk+JBpo3b9fclayYzgdtbrSqjBO84prGEfwv+\\\\\\\\\\\\\\\/NlEEO\\\\\\\\\\\\\\\/d18e6gKqaYyro7FX5X30H\\\\\\\\\\\\\\\/j9qjz2GTUWBX8lA7VVj1pwGtFbm5LEEIDc9lIEgx7oPxhWU8bSsESm2Jtg4m4T4s4p5J3Xo4DF2ZjwhmodDxN\\\\\\\\\\\\\\\/HDC\\\\\\\\\\\\\\\/ZR0mHsU1uz+AZSaFWwWl\\\\\\\\\\\\\\\/PbKBOEcALECsBqRcA2pillNFjsB0scS1LgrOHaTIlJZXa2d3DqfPgsXLAZWoVCfJx9+s4h5XQvnjdN6Q+BhCatza8Y2riH7v2ZzfSwhrG5PonKG0wRuz48br8f1ZQXwwfPKDWA3BkAHZBwY\\\\\\\\\\\\\\\/ygDZmlyNVB6QHxxNmrgHQqEpmjJbj4B2dNSwHMD5W7eCnsBBNUxJeAR4PHWI30YJjtD6qG2wLdiNuJB6S\\\\\\\\\\\\\\\/mwlh94JbwLFMsC3tpboiTSyG19sHUDYyQ4lp\\\\\\\\\\\\\\\/kQ4SowZgrk9mpKcBAQTTww4ag=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Eov8ns4aLsj\\\\\\\\\\\\\\\/CwZlfdnyJA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022179e817edfbdcc63b62e0b92ad7f469476a09dea60315b138acf9f4383d3f9ec\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/3\\\/e003420.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/3\\\/e003420.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003420\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003420\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003420\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}