{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022PgqBbCo08q\\\\\\\\\\\\\\\/lgvnYv2u\\\\\\\\\\\\\\\/GzhPCV6nJHrt4TKIF7S64qGrdLPlt+kUI6fAIYUSpHqk47xHQ3Sll\\\\\\\\\\\\\\\/nFqnbx7velizRpXNwVHq4v+YTHz+d\\\\\\\\\\\\\\\/dX2PD+PbGheJKuigDZ8nyrERnHhmrjI+HzPi59eD52+UYwZOhcin4xYg299ON9HTFa2B9B9MmJLkjsfwhkFjN4O3AFksB9428DYXxwB4lcTlRWXJ8f1szUZuBYqomu1g21sIGKn7IKfLYcWEk\\\\\\\\\\\\\\\/nOu7F1GswiebQOyANO0feQSBV9VMvP4pSz4A5Mo8Uu0dXgPlFGIYVPirKtnZVifkTKcWFlU3xay+kBhWCl2f8pvyzQVuw0DYEld63neGTW1TMkeHyss4mRBfJ+zUzaEsag\\\\\\\\\\\\\\\/nhN3kwieUQDr6TL0HBZEcsnV0QGAOG2Jk1YsknfJKcJv7FQ5y1wmviLuJQFTGA172l8TKAzhsIGSyGj\\\\\\\\\\\\\\\/Nmg\\\\\\\\\\\\\\\/uU61v9MoW2G7mTCBgFuqOlvh\\\\\\\\\\\\\\\/etrgtujW5Zi+YY+RJRQjQbGQIUTahR6nvAhesU\\\\\\\\\\\\\\\/iuQmLQRx3jwODBlwzuILU9R+ygvp3FbqvgLFy\\\\\\\\\\\\\\\/oq+WZOMYKnX++wRXAO6lD3JpLwLbG9Y+1qa76EYPJ4b4BK5scF6Gn7wNyXzDwmD2PZrpWcniyptYQ7pUJu1Pt1YqIqruz3S+1ssdXvgi8eIrJo+eZ+uHc2g7Rn+Slo6Jsq2qv7Lgbs1+t4JUNke0I4YGVFjPXXVBtywj1eMl7wMdgZRP2vZ+MdZhppFY621j\\\\\\\\\\\\\\\/qxcbse7DhD2tmZ09MroaQbd8WFgnEG6i\\\\\\\\\\\\\\\/rIlgARhtX\\\\\\\\\\\\\\\/4xatyEgtT5yUo+yGP+4Om\\\\\\\\\\\\\\\/DEoI5yFjV4KiC4kLNjaM\\\\\\\\\\\\\\\/TkrLP0pu0rX61z\\\\\\\\\\\\\\\/UPVJcL07dfIMp9rxMBFBeA0dXOjwJRzQ1SyKZ6gX\\\\\\\\\\\\\\\/ZXH2Hpb8s4YzLJdHTzN1f\\\\\\\\\\\\\\\/HuP6iRU5nWuVxZmWALmw8mFn6TYckFNi75HedfEf0oM+3w84+zAmT3sr1xfzmlFfc38jaRkRi0wr6kcg3\\\\\\\\\\\\\\\/BBzZtvci1gXjJerEx8UjO4iwJridmWvCfELKZW+jlIU3xza1Mh\\\\\\\\\\\\\\\/XXFJ0ZJtkgcCORyj3jM6JhGG8elmsJap2HOz52fQMO5DtpO1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/xOG16mnJumdvftmPochpICAS2TbIl\\\\\\\\\\\\\\\/4L\\\\\\\\\\\\\\\/6C79hqw3jlEi6K4jTDUrYP+ih1iaW7HB9gxGFPw5zJeSGcwzbprkkw67xCc1KlgW8UhCUq3Y8UiKHqzf4BowTCj\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/4STCjvZvLYIAx7RsULozt3MJlOhTeBgeMG9uSoir6BO5mIsesgKTznkWwnv5gcCZzu39ZLXUz8pvZGRrxakW+qHIIyy07cj19FXDjKYpag4ZgZ7btvFJCnInshZ4wMAqZMczjBVwiunQzYnBNiQHgXTlPqwKMWFFw40zXTvcp2RMH4rmR1Orfu\\\\\\\\\\\\\\\/3IMMM2bgWWk9iwGgSBIgQtix6LdDB4cgAR0Ek59czX2HRV\\\\\\\\\\\\\\\/jYLxGRREQnB3zLcOgyiyEHP+BAOA\\\\\\\\\\\\\\\/Ex442FUSJYITqfYjSsUhp4E+L9FqHbjLPSV+FQgqdlPiwT\\\\\\\\\\\\\\\/o4QWU27MNwW6OidscQi0KuvoV\\\\\\\\\\\\\\\/RbNtJSp\\\\\\\\\\\\\\\/lf5yeF5JMEtSFIAiLxC9PZwWkYnkvwQbMy8bNT1AteJQJri4oEXH0k6mZDiSjrG45mZewX7sg\\\\\\\\\\\\\\\/1wV\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/HCEJDwVL0Nrj\\\\\\\\\\\\\\\/wGKs8TmGU3Au84fq++BbKPaikXmpEhnaHiFPpu+WEatM\\\\\\\\\\\\\\\/uHXtEv8d54KTPO0JnGHKrWqVhLxe9nDB9NsZSHWob2jtDyrDNTl2RuN9zVONwEQee2JfZhfRRYiMSSw08rMwYFvCrgfRxx\\\\\\\\\\\\\\\/4wvm0IPpYREsRaRlHKD\\\\\\\\\\\\\\\/vMC1sVYlP\\\\\\\\\\\\\\\/fua6I7lPzd0Jxfa52quCgD\\\\\\\\\\\\\\\/wG5dEjOtVMdIZO5ciskdIOvfwZek20Tf8H\\\\\\\\\\\\\\\/SRbnSVTBJKzDe6DebCUKawcBwj0R6v4T6472586e2WftFiH1Nas9uPpcFpBCO02rVPYlKo6j4PwupN3LnBUGHRBYu9t+Shx4nlZ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/kruQ\\\\\\\\\\\\\\\/o4er22v89XW2KVws1z9dBEot36wDX2s8vxuic9iQmo5bAz3A4Xa9h1r9r7qJwcS\\\\\\\\\\\\\\\/afCCyPekQaV7ewWFTT+CO8B8FX8NCQitkJmJDCk3jENWMfi0Tg3Ez7Qsytigs7XXw35\\\\\\\\\\\\\\\/45qbuY47cDUrXaO26W+IOZ38ILrD2lQtg+VcTPUEZL\\\\\\\\\\\\\\\/2u4FEJvI4Slbxs7Za3aKCc4nh+1+TQZFAnOpiXzY5wVYe9uiAWFhzwIFEu+nJoQ0pLHmhJeo23kw9TO8noykqDbXi71zTVTfBESUlTdjCukgDxTHueicJmJY+uee23Wl9sCrsbyLZPbD7PpCOJNDBf3Ndf6pGGkLk+JG39KKxk2o4fQP3oGx1KUePlpOfiz22ecYdqcaHLxb0SDCgBZKWWxazGoT0xyzUUDEjDyXhlIsKT02zXjwHYRSqI1jEzm+dWZvuCWWK22JYubsXKclNUmol\\\\\\\\\\\\\\\/k1Kd00iDsok9hpj4djryj9nLLAXNT113eYVLS0AzsgB+ouOF0rJBVgBgBZK\\\\\\\\\\\\\\\/ACFHbeXyQtsPWHSP7RSaQQ9M+BkHdsDZQx6GTueQt+djsjEjTFVY\\\\\\\\\\\\\\\/p5Yzkp2byFXHBRMgxrgeZdqHchy6vLR2cJFc4M=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022BmS3jlNs\\\\\\\\\\\\\\\/U2XQQqO0dX5ow==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022223e71c35f7920a3806d901f1ba01c71423f1b18d8c9391dc9da9d9480be64fb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/3\\\/e003385corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/3\\\/e003385corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/3\\\/e003385corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003385corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003385corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003385corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}