{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022mfVs26ajA0KyStTz5ew\\\\\\\\\\\\\\\/zSsS5n6MlbhvBRjLUyI3Z92ziRaT5n\\\\\\\\\\\\\\\/iDtMfY4r5+oRpwXs2gElwU1BHrAGCWa3Rgt9fttuYf1ZNZUgCafE8HSBWA9niHq2E0EvLjeLG7mB+ot1vFxbAELWrQjMbPJbf5H5ySorFH+pMqR5imsKnVAjNK+J4llhUlak5c7D69ozpQE+rdkw+PvU3S6MsUUFdruFaF3ASWJjNN+qTlRZZsE3OEr2hkCMYWbrLYDhB+v7gd25BowTK2Uv2kR43cIP6a9X5Mi31cqORiVtAj\\\\\\\\\\\\\\\/7LaszEoPsS8Qw2iN403pEq9KVxTnY1NlYLtpSbdgJph5Mcxk51BV0XDKwYxIN7ScJlyehTVNN4hM5AmqUxZe2a3bHRqg76tSzsOYRI5hpx+W42DHAm9kCLokk2AJlwxNtisTAjq+pDH6UyRo2yglMq6u3Auys4w15P2f5sydUojp46CqogPMjZfZ0Dfn6MpMcjINPo7+a\\\\\\\\\\\\\\\/limCrUnYu5OYeXcmmZtsUHR+keMlHWSLRD+jOYHtp+siNHDAorjh94r+6M+5nfGKPcNJARyfmeDabo0+ejnLveHuzGH\\\\\\\\\\\\\\\/DaLa2eKKs27pWbUVPItaPi75vW4bryCzX2uUTmDsv4MNiIXcdN8tp9RvPT7k5pErt9lUEPTtkZIu8D8r0CRtl3\\\\\\\\\\\\\\\/lbAFJVypvmj3pb9MKjJt+OycYwn2ACZPLbMi63pyrZBCXlOkmGs92Q0Qj2Wtz1tYuyFf14doxw4p8Xj89WSP4H7\\\\\\\\\\\\\\\/i4nCiiyWNT\\\\\\\\\\\\\\\/8+LdHmYo2LU7MtEX5NJkQZXIAhBHD1ztljwTr5ir6rktTAvR9cKNEniyv2xPsI8PmSQN0Ad3MrZ+ucWeH8K8X7JzvjoSe0jwyqIXmK32i07wz5UqXlTS1S8YhKtrdaEQUnQFhuu9Uz+RwKJ7\\\\\\\\\\\\\\\/n517bvVUh0LyqXyLxkouEVpthZRh3cBP+5O6G9QaStdIvTSl2p9G9iy5tkhGxJi3Ezf1k\\\\\\\\\\\\\\\/18OnfqjGUuPcaO4EbNl86aTiR3Lxn\\\\\\\\\\\\\\\/6GcvznbBIa6vU6aX1HzRxudLCNfcPmn5OrqQk5bRe74hfe5P\\\\\\\\\\\\\\\/N8fogjwa5asPen6dlFeakFP\\\\\\\\\\\\\\\/hCZQOYVl86O8PIpl\\\\\\\\\\\\\\\/Jb7jKASdkS94YkBgUNQ7xtaQU6imK0LHZwPBnxPkNGLjU\\\\\\\\\\\\\\\/z1KZkT5Hy3qEVUGFXd9DZw3t9fN+H\\\\\\\\\\\\\\\/8gdisLRvHg4esOZPbiXAEvuuV+0GuNghyt9bF8lPpfApnSaXh1kzyPa3KeJJYsM5jBgBHRdWEJhRVtS8Ropsi931HNaooXDf4rGo4IJqAvFmUsEXrfpPNbFGtY8hMZFWHiJaSQ+0qGy7E8Xkk+wJA77SLbyRXh+NPajgG\\\\\\\\\\\\\\\/dgNUrKNptH5eff7sT1wDzULZBusZ0akUbO49P0w8XYZgRhuUB3A8ygnFrzRTpDBFky9HSHIPsATTjI0vjb6cRSBUVS2iJxDsaa791vVSGlbNaTRSRO6Cqk\\\\\\\\\\\\\\\/gOHx5YstFlRsq7nizYYQdl3sKVO+opKr8ec3F5N+7pUaNe1He8BTYhQY80LnPwz4a+nHhQKZ03xqLAlXNE8xcl1lpDRyjJCwFUHh3lPCA5tnHCFNxwFeIWuM4izn\\\\\\\\\\\\\\\/6\\\\\\\\\\\\\\\/2KtnBy3ShmkOITkmF3caAfWvEu+II4EawwpfRoosfWe3v8goQTCX4I1\\\\\\\\\\\\\\\/xksSlhlvbQ1RN2JwnW+5PSIRo\\\\\\\\\\\\\\\/ip\\\\\\\\\\\\\\\/MTPjCyicRXKBplPoZdDUHvoYxkDmvYVKXoalyKQ6Dww5VPW2\\\\\\\\\\\\\\\/zvK0IEgVyr6uurVvtfEz8sVAJwrC7YXACFwnRlQrZibjVWWUnKHeeWTvnxT+v+D\\\\\\\\\\\\\\\/TTUy5Jy\\\\\\\\\\\\\\\/s3SdgC3KiP37zv4wbp4vRMxKhsmx3xCGJxc2LH3MHcPfuzXQr8xZgEOHnerk9Tooh8\\\\\\\\\\\\\\\/dTbeJCU3SVogCJfc+u47kYQVNe5b+1qXrOMWygHMPQiubJx7ygbfOclAtdjryIpYCJhcFgNt\\\\\\\\\\\\\\\/o2Fe1HJrTsL4zI8N8NqG8lxrhg4Z5CjttncNCxVJa\\\\\\\\\\\\\\\/2+FmNJliMH6xgtHeE2bOf9UvlZwz4eLG+GTD4IkW06fseypb4GgACuZm05xPhxprZ1GFXaIV60ii1BTJDijbYYndpUOGkozD++Exl4Unw3crIq8gYXWTNjs\\\\\\\\\\\\\\\/EEbfwM547aKtPVMvSn1hR\\\\\\\\\\\\\\\/9inQoR\\\\\\\\\\\\\\\/kcrrt64Zuv\\\\\\\\\\\\\\\/juh6yKvUdpBzaR\\\\\\\\\\\\\\\/KIlsZ3txEIIcGYaikiMST3xR1InpXxjKKG2koi7AWn90nLn8PZSvg3cZCSDu3LhzV1SDkgar6IISEj3YwKTHpk4UmJdxRqrIPQPLJ6dWRkyN9G7FWCS19GT2IO5gnJgAfir3QO7+qLIlx\\\\\\\\\\\\\\\/4rQNFPGyA7roFL1FIMnE57XdtdO0huyE0LG6YrYXEBfWZxBC0jVF0nNUn7H07l45Q+MUFWiNZ7dL4zjtcklUaI6pgX+7YoLLEqqHdUG3qM4Yroawlk6m6GzryIuirNHGIzcrwKWEF80jH2IGJV87MQGn4IXRtNGs8E7TcoaGpah3uuoJMg6CGhds+BNEcNw0xPrDVwzeBmKU5GvyZPJKB9sSxkiCxZKQa+gYpv6tdYqQgY1fe0EDCbR2R0Sollqm+s1ZL9rQ\\\\\\\\\\\\\\\/OYCrPSNGXUS\\\\\\\\\\\\\\\/RAovQCeIptx3AUlwlaZcKJ7U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022IujE+ZXZqLCf2EbLsMduIw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a4db69c286f243feaf2bf8698f1eb32cd2cbad0e44c223f9c9a2f25807cb36e6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/3\\\/e004191.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/3\\\/e004191.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004191\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004191\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004191\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}