{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022LmkdIjueM80XBc0LPJQfEc1hTT5FQghLjPmMvznGrS90nmqqano2GXN5a4kHmglXfcVsniTZ+76j+Vzw18HNlv2KuA06wPVXaSdREs+g6l4SOs1JGAVaCBC8YLL1fDHAsiziH38YGkQCR6OnMFt82FsBq4y2wHtcqB8F81CgxrdyjmdvfUNIZ5idVoUbStxBcdShAGkleHZAavG7IVdqDi\\\\\\\\\\\\\\\/qsVS98AG+q2xanWMShFUhEo4v2RJFy6mCRoYehDSK5sc4RVB7V4fA5L0OAI7+U\\\\\\\\\\\\\\\/8+c\\\\\\\\\\\\\\\/DkvNr2Khf1q7B7RmvaUMDGSWH\\\\\\\\\\\\\\\/Pt53Yl0EZUYYWa1x4ED8pVZNAa9ehoxhivf4aTDZhzNOuohCT80UA4TURGyPA7xZ2mDuxoQcIQA3kigJf54XID8upQRgAr8zbgRZ0BjfMlFV8gwQ6MNMfaWG9fEv8ictKOb4S5E+5qgDkA7DmngCQAs3ikc\\\\\\\\\\\\\\\/I5jrycZV31qlC6pB1wPzQRADwqM4m\\\\\\\\\\\\\\\/YkNCxKA9+RZO6Sm5a5aZPE7ULskuNaxP53HZgP64kGDBjuj0hZNfqipZA8M6RU++C9+zy4W8fHcPY+MGpTiEfOKrYLQ3e2ion\\\\\\\\\\\\\\\/5jMT42\\\\\\\\\\\\\\\/8IE+6tG24SS1RSHAhKHoh4X\\\\\\\\\\\\\\\/tTLaU21l8fgo4GrWniXdawEKjE1UOw2roZt0IwkXGbXE16s0c9QWBcC4cNTNRjwFNi9162ZHZzzz8Ja0BB3YhgK5E2lXgQ5gpELtVakmoiKBar8\\\\\\\\\\\\\\\/zQNFpI8Cr0UooWaMNTDFBp4HmvOUyCzTSR\\\\\\\\\\\\\\\/cH504mT2Hu+9BdrRLTIVt+fo2+ig3nk1Zeo49nA8VYPO+QWgfHSuXpRNbyph8LNcVjEgPbCJTWPnccNH2fY+xfA9Qa9\\\\\\\\\\\\\\\/y1kpbN62OgI085lieoaWoujPK8Yhw2WkTmFoT9ZxOOjjr7rp6kTiiKJeh6vXFguS9k30qz5AnY6goyij\\\\\\\\\\\\\\\/6Q9LUqYA3zGTbFjMb\\\\\\\\\\\\\\\/JU8EADHl+kqXRJ04YKc2qIrALgCCBXg17cLj5Wu\\\\\\\\\\\\\\\/V1suWAIdyAPHShCUxMmU3\\\\\\\\\\\\\\\/TWv7oAZYOvk2jPTP8t0OSieHY9duCQn8l9JHDvzDPpWpAd+vEKkmpAf9mrGLUpnVualqHKXqXx16D088UUN83fj4pIAuGAxLc6y4eygBF8EW\\\\\\\\\\\\\\\/v2lG4i2dO2yONRaBi90DG0iQWaQKNvtrpU2eRqwrbvSoKURAntUpyK5jhWrxLlImu\\\\\\\\\\\\\\\/IqoF\\\\\\\\\\\\\\\/9qSxBGo+MUZpdxpylgXYCulGPnL1UNOpHUY9zgpPREMXaw3DjBh0S2L295glJC2hhSAtYeCYk04szIYR9nk7n\\\\\\\\\\\\\\\/WHGMZJn3CdxG6x35g9TUBzZwWz0C9FZXw4W\\\\\\\\\\\\\\\/HISAdSO6JUO9r5WInmMv8tR19L6F9Tqdg29BCuknfNtqj752I6UadDxdD8PF00NRAizeqTIYpzDN5l1mVZKtOUXzLQpG2jllpjr6kBKkTI2XUeZHTUQJ+lE5108sknkURA218F3kgTMXpiuUxzRV\\\\\\\\\\\\\\\/e6XepnIeA2yY6slc64IyvKJQt0AjVE4WWdYpXMWn446GCqdlN5TXltlTC64kUIu8kh\\\\\\\\\\\\\\\/ySfkfCQcWZdl0kJj6fLVJc\\\\\\\\\\\\\\\/fvmzR9G6BGMpmJH99yIR\\\\\\\\\\\\\\\/GmITT2h227vdIxxHalcszuoFj7digurnrYhSmeDoxzV985uk2MyoE+RZgHifWMIHqllGBTxC\\\\\\\\\\\\\\\/VBCuAavZhITzQkqfm\\\\\\\\\\\\\\\/rjMGrb6AIdUVlIHkPtN06Ng4joPK6v3qELFMDwWjc7CqAKwH8GUTKeg5N2bzLjlOLjq92zsUPB2ufEkxWYpc3qESHCzA+T+ovh5rohILDo4fWgznjnugySt4Qnyg8xJGLhvPTLvx576loCTLaaHaABmBm158E0UdhsYF\\\\\\\\\\\\\\\/4IYSZRz2Yz4idlmPamvlFOunQM3gS+pKehr0myETN+irjdbfjGGODxAMceXErTZSHLh1\\\\\\\\\\\\\\\/dLYyxNoKqlzPlMyhqqopsTeYvnUFA1Ev0ui9ugETcL1eswfNzxTtNnz7OE5CaihGHNr2W5G14kOnZsyOj42vbIYZ63i+2hxWLpwDlOYxX0Efyb7Ty2DdXpi7SmfJhewmntq24OZhXsM4Uf\\\\\\\\\\\\\\\/nlgkX7NQ8Zk0MA2sHexcov8uJGh19E1rafy2BcWpI7MMwDncYUcYaWseDm1domt3+dFhTbBzyGaIiNiMwI9agaqEO895eSalSt6iNjYq3TaoWgjYzi1xMuw5Bx4d0SSoK28UGGQ95OjJ5SmA0hbFIVykrDCdohPxpcrpOmZcerQJyhIb6zVyz69IQIVtCRE7lfj9B5MCeZ0Tfr3ixkk9aSbXxwr4S7XRh\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/4Bh54LKGrFQlh78MjxMqOHSwgVRZx3HL6ttUjWvd7zjWbtakxQrxlMsu2e00fKzjx2ooG+6MxA+3LfvtsXFkjCjPvH6113sHPo\\\\\\\\\\\\\\\/NV4cfC84nln\\\\\\\\\\\\\\\/7hrrM+NB9\\\\\\\\\\\\\\\/GFih5w7J97nxjihgzCQ2\\\\\\\\\\\\\\\/P37dxMEFR5MOM7AD6f9gR400V7Rslh53rzzIeOhSDbXZAm3Cv38vg9J+Oo0BJ7VQ6iBKIQmR7iiyfSadW+xAwLXFvVdY58FCDogOxzQRyyCoOusNASzf5XKkTs6PLFpVze247887Hj4MRSSn\\\\\\\\\\\\\\\/cweJSwrKxGhiy15328n22VpzM54MacfkdJDg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022AvAG71KdBviboPN9TYJ1hQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022836f8ab19e45160ab6cdc6e230020d7363cfa11c7dc4ef3827a6895f753b0774\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/3\\\/e004115.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/3\\\/e004115.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004115\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004115\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004115\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}