{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224dEkPw8sL4O6mlHf7lWenblUxQDk\\\\\\\\\\\\\\\/2IM\\\\\\\\\\\\\\\/XwX3C3f\\\\\\\\\\\\\\\/UFVALrhA2Pvq42qUaKKnijaoOuRyfigHI\\\\\\\\\\\\\\\/kJBiV5msODkF9WnpbNhjm\\\\\\\\\\\\\\\/2KmjF\\\\\\\\\\\\\\\/2AoDgMi2QtU45SzLtdrrMAeMCyIvcN4sdQvkYvbEPhv7zoRGBOFgF1TY\\\\\\\\\\\\\\\/owRxMCSRkQbAhG7UPvyPNqHH\\\\\\\\\\\\\\\/mtx9fYslsNGojICCUqrrInmVucz5xa5WsMTjP5iWGYbGjiht\\\\\\\\\\\\\\\/aOShAfq1uqYmkQJLJhA5jROpjhsoXHl7LD9XomFYjgstMvanOaX1hJzKZ1J72CGL8QWgHqOP4Iuui439WAS8OxOJNnW\\\\\\\\\\\\\\\/MPfZDedJDvyjh+JT1JmW8V0JFR9007bgeXaYvaAtm2WBjbEzi4GLu6UJXI+2d4DuI4Tu\\\\\\\\\\\\\\\/kZXLby9InexIKEbj\\\\\\\\\\\\\\\/U\\\\\\\\\\\\\\\/NYlcelm1ndaqnMpVOtJ4zXjXpnP8ke5Ct2kVSBXB3D99uCOZYMSN2f7FGOzIF3w+aaQ8Ajcntq95TIqXOVX8Sin9E5B6Gkn+j6fwDTtiP7m3eLMTm24c1zkiZI9nks3mMcnU1hf\\\\\\\\\\\\\\\/WELYqI7JTtJJCZIZyZzHz\\\\\\\\\\\\\\\/4iQbMJChZ\\\\\\\\\\\\\\\/qEdPjLNwCnTfdUovjGj1XsEjJpTMRcJwNqHggSEgtBf4hVYizA6TB7kO94WhRkDMgsdIfttAShXU8LeGH8Zjoi1G\\\\\\\\\\\\\\\/bMfkjPVT\\\\\\\\\\\\\\\/eHrTgQjh7rziFT0KFkEWJFLGvLPRCam\\\\\\\\\\\\\\\/5mj8C\\\\\\\\\\\\\\\/frW0It8wOJXCRBcL+ZOlU0LbuFQwrX9uM0ywlm221UOdXafKt7YCOAyQxNYBsifjfoZawtYZvMBs2Q31nleRUo\\\\\\\\\\\\\\\/dhIcwLpp49O4WGnkKn1GQaxN3CygVhN1NcKEFxVVPC7fi\\\\\\\\\\\\\\\/qIwjTVjOI2EIn09niAJ2HEc5FRatftwHJ0kZDFU7IutpcnzXEjhWl4IJ2Ce+vDNbQhePLO\\\\\\\\\\\\\\\/eOAFZE7Xp7iDwb5pLa2EKwp4Lc3cuG\\\\\\\\\\\\\\\/O8FEJbhU6rLDRW\\\\\\\\\\\\\\\/Q3FEYWyfi3pRL2Cgfu7\\\\\\\\\\\\\\\/Hu0107nD1pn6MdHf7sPJ5avRMx5Yq4JU2TgClnPh3OyzBbdHvTdiLEBI3VumbJXbWwBguLOrOWVoMsKLFDH+Xg9Mm1aaWISFr5U\\\\\\\\\\\\\\\/yA5w5SzJw4fwCg0mwWjDgb3pcM3RxrVwoc7weHu1IDIkShE5TYyRJizspQupyWELJFjE\\\\\\\\\\\\\\\/sR5Qhc22bxdB+bmrkxZPRb6l5T+H+Q4RN9GCFDt7Wpl4zei72AGw\\\\\\\\\\\\\\\/KK\\\\\\\\\\\\\\\/Ljwd27KzAvVg89vAVGtgtYGKt2YKoQGneZ0WjseM97D3DxBXxdVDKv+QmVovjq68ula7lX7VR77syT6fCThPpL0gDpKyMJVzN5BUDtbQtOCJ8BJrz5TzgOlgIow0\\\\\\\\\\\\\\\/WLKyLOOjX1qDo1UVJgQAkd5+YPhIuOOToysPahFHZ+8xSqrLTsQJOLlHLLISZdGVQI7maUDeIueUg8gpu4zW8\\\\\\\\\\\\\\\/NEZn2KBy5A5GZilDuhlSRWOG1DyVqgCeC96cpRZPpg6yELf4gh7g+QoGOZD9Py5xgpy0Bp5wS6IAkGyHWtpxfXhomEq35tZqRULbPnuNrwljro8HYAq5oKpnzdDnc5SeU3l5HGyyE7tM2kXbCpvUY2NCks4KLiCy\\\\\\\\\\\\\\\/XN+ZDU5ImctBekb6BflfUXODxIFk8NSnZ84gvZcd3gex8NzwfpzZ0PsUdJMgasgGwX0xHyUK1aCT9CsYr1aWbLA7iovpUNrW\\\\\\\\\\\\\\\/yTC3kejJt9fY3wh8STb+uhvgtA2qfNRinV6mINcUkx3mu31yoxjlwn5J4VGxKB\\\\\\\\\\\\\\\/wX7XXABe7BHRsvr7bRW\\\\\\\\\\\\\\\/6wILq\\\\\\\\\\\\\\\/vaWUJWNiYYRXQ8XLhxFqa2KAnYu+jqFuuCvWi6Ir7g9Hy9Jc40YzY1GymyF5\\\\\\\\\\\\\\\/84ZS4TEpsbGnvELYwNUkehWCzwRcPVYbrD+Wxl7vyDLdQQk8yMWP04ClWOwTZbxpQz9pO93Z8OX4NSncuXYm8GlOxbZWeT+gvdErJguFo0f29hAltuED9p1HZ8Z9pbkKkWRTjq6XV4f9S\\\\\\\\\\\\\\\/ahj1jtNzpzFv94lrn3CuCSeXTduR5VW2WMR7KBAxDHga3DdwczXsn6Cg8d3h6OLxEObGdjgt5pJaj9C6EZr3lqZE6jkKNLEW77FbmvJfCUxXqRGg3nmCpCb3zbdjrHfm\\\\\\\\\\\\\\\/w0SIToKTAP0V7xb7lbQFiwIk+eYoizLgPDfY5itxQ5spGqpuU\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/5e7pWLRdT3\\\\\\\\\\\\\\\/8nukchUjoynhy99q\\\\\\\\\\\\\\\/fTsekNmImUJEdgcWFeftt9GhguvS8K8O6d057tFOBUmRsnLu7x0IBmqQoe7RrRxCyCt9Xe3nEvay0jK9vrFbmQttZrHeZ7wtONw3wCwfjemypvAWJI88f\\\\\\\\\\\\\\\/kJh5xhUu1\\\\\\\\\\\\\\\/8J6WU+Haqb8jxvx5IvKOQ4j\\\\\\\\\\\\\\\/vLpquM6j1L1TA7lY7CO3bK8avABGiufDZRPPFev26UtbWglhB2fuMMPsRGO5rEMSxHQWaw\\\\\\\\\\\\\\\/0uiVal4zcW7skuNDwc+1x\\\\\\\\\\\\\\\/PQO+QWc2Ms01ntFEvroaro1v9bU0zAXKHqReEoZFABSmFUNJysjGY4vJLwRtNAGwXnhdY1DrdkjKm6NBhj3lomsBPP6WnwWOv4WnFeFLVmRM0EoFR9sgITtAuOgQoVvxSeDs8Oxn+fiAlGlgeS4LaLz8q+n3BjDWzHQ6Skl5To73bak=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Ws7wBd1hLC62gknDZwhnhA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220d2cfdd96e3c3436193984e692520d137f0fef69348519c3ccac8cbaeb572574\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/3\\\/e003958corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/3\\\/e003958corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/3\\\/e003958corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003958corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003958corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003958corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}