{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Zpmz+yHBNV\\\\\\\\\\\\\\\/mareMVwjtouCZ9HVXfeJHIJ7wJ8Iui5KFrOVn2ifpqo2kycAeJWxePnFvaHAW+PtBBWubVCFoSs3XSgtlwfX8ucFQAlz0aqcyoY7\\\\\\\\\\\\\\\/ctehOWuIEoFpLlurw+eHTZpvJLrDCzsdm1vdV3QM4S9Lp3HzZXDpNnE61ffafvsilPrCMBgUAKGwREEdioCayZ2woO1yy3PsLfYW3tK\\\\\\\\\\\\\\\/p+A0iEG7AjY9bn3j9e\\\\\\\\\\\\\\\/pbcAoKMDQVmQyymes4nqArbShIuH86NFI2\\\\\\\\\\\\\\\/q+4YvYdua27aX+6dolFduwOXBDYuNm0rY2ZlBZNsd+77GTjWoK7toEba0aACYZdbihBroBgXtXDMhJAG80h+BuJNspghihLuoydo5o9vt4uovvTCJom1jN6zM2ZT38ktUcSEMpjJLdxCfPFd125nrAO\\\\\\\\\\\\\\\/XNrqBhLc1OB51nPyWz55kW9P9ajYx0gCws5LFzhzSMeJp6\\\\\\\\\\\\\\\/EWGr1gPBgkzUb3G75GkK+de4axgs5ToOJaAU6X9\\\\\\\\\\\\\\\/kueE9GTP3D6PhdvYujIdI4UaXsCFRX+9KOquaA9WYocNo6fdfdhYUOkuSZenjvIwN1kJ9Akbry+xJVkeACH0R\\\\\\\\\\\\\\\/Jnv\\\\\\\\\\\\\\\/NSX1FAkWwSQOKosXBiWJQRF7\\\\\\\\\\\\\\\/4yCUZQhUEQwWu8Qtri95dQF1lbjAKSLZlPlW0MAPD8i7ueKAGkqDGA6ugJ5GM9YAxuWzYbqtJU6Vjyl\\\\\\\\\\\\\\\/qKGsBni3DvxGWDz1nrnv7BLYgtwLhG+ZsmCY5EecDhTz0j4qlFySMoCFcJueOJ\\\\\\\\\\\\\\\/fdgfwAUkLMMrunYifoVO7KsoAqOdHbDEYWN8Nc8bgM22R7ue885pCkPn0oRzkSng18PqEaPQ+jKWfcIFjeGx9\\\\\\\\\\\\\\\/XHdQY0uY5qRAjtxg2x\\\\\\\\\\\\\\\/kUDuca2dZ3C2ChpwBDp90Oo9rPZfDI8Gvj3kki2cehUb76robT2L4uv9yJs5wx0X+w03p6RYgR2qDecDPEPzAMOeV7nbkLo556TGOl\\\\\\\\\\\\\\\/z1axH0wfyVg+JwEcvXLHjoCSkTSluhgdex0o9YJtSnMkkFoycD1ZO6cbVYpXAMlIkLb2qbX6YKx4z5CIIPT5e7CkgWP+EfGIHAGD7RZZMyP7xjcabD1CujI0CNycxxxT10RaLavT8JILQoUTyjq\\\\\\\\\\\\\\\/EVDgqb7EpGak6bwmCvOc5nBg9v4X77UMlCfQVFrVl+LAMrnbRc2TZ1RyFfjUpDCgy6XmusdiAsUjbcef7J93Ks9PdsO1GYMZoQJsxxpkKBSftUaynfW9VTSmoi6rSEvBg8O0ZpXMhnPaupUKPsUJPvvufO2lHs9fgMoKSK1ycpoMtUdfZPa+x3e539N5FN6ygzFJXDdTcJMObzIJqerMUj\\\\\\\\\\\\\\\/pKEGgQRQVpUTbghL3DqjlYlJplyB7sZNDOqoKJ902epjbnua\\\\\\\\\\\\\\\/xFb4unK9ZJ1UHghbXH59uKoVQGvS5Jya7ds7TBPhOqRXaLIO4u9lFFOZmwRlEw4Elfte8YJNyfEgfEAVdHbXn+i2YYuffNUr2Mq4ntkGw363vYSxNZnEwyCm4RlBXbmiKca0kpI0KRsys6Kl5y\\\\\\\\\\\\\\\/9k7DtL1lBqNX5vlw9TeCA3NXiLsf1+niWAvPDel4XzPJOiS2R0WxfiBRvWtsGg4zM1dmedIJ7XwrbFcpLTxyPVHJfxOEhipAhjdn\\\\\\\\\\\\\\\/ZYr2twSxZQrGkOtIO+2tqxTaDvqX3lWoeoAHXZsDQTt+RISX+krE2Z\\\\\\\\\\\\\\\/bVLdLkC0MITDTw63hV2dq0smCysQG0iE225Bz9P3wR31cpi9QauM83I60Ci84smGON11CIZYiUslK9uhHwEU6Z6ZTR\\\\\\\\\\\\\\\/RW7YxQnnleybXCcfxv1Y0RC2B8lnI4KSO5PVR7a33JOqmJfuBiUfoti+wYr4BZS5Pdih5FovCVxeyhzG5xQAw1HlQIZLz2dg0vTfOOsP4qfYFXBNWQVx52NYBjFVhrS3anT8yWoUmFRlPw5zGyOMaiMRWR5635HW1bkpbqArkZCgHcRYV0wE4Cx0Gi\\\\\\\\\\\\\\\/R9IsBfn7YJlNgVpcZ8DL4nYiX+OcboYxh4cam54+PxMGfxK7kNtreQut4wbxLkOkZaZX8kKbWxwVbR8c\\\\\\\\\\\\\\\/WvlSdJ5AYKn0kooe9wbNw+GZWeUfFwYCAXL5ULt1hr1qWCnrXmthnFZCr26zdrn01KJR9l9+YlYI7En81P\\\\\\\\\\\\\\\/Om4pDBjDJPLr0x10NWsOVNekYz6X0+OC\\\\\\\\\\\\\\\/5mqAX6HYxG3q8i89ZJZT\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/L6NcMDygvY8N6uGiE09g14UOewAGrCPpnNDUwEdl7s8hzbev3kdiD9Lt22MTB2GR06JzBH0VMj\\\\\\\\\\\\\\\/KzCADC+KtN941nSB7l4AewuO2ci9RcqmMtwSZr0ywQeGt7d4+6bSGDqwzXKYo09JFe\\\\\\\\\\\\\\\/hOF33enbvc8vOwlFE8xg8ZG772viZGi99GhZ+jKrJXWJ9MRpdRNkXzTBfITytKCCxAgWxl7fVW2Feau7v42nMREss0mPgPzvwP8RrEFJ+ChysviSO0WhWeF9FHf4u++1NJjSXqk1UyZIBHp6K0w7Mc0oUHgaqKudGxpcgbrJzlT82ZG43JXwgAu1DdaApl8DrI3iyep0hebWA05fL1ZjXjehQ13m11qv9RoOIR9vSQNKF98C2lHLm4nY0trmUJHbDRpANIZtRGonVgpNo0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022S4w07dBFX28vtymmkI5bRg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fcfc19ccd44ac580bfcbe70afb79f7982892a60f81ed72e62afc1bd1270a732f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e003816.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e003816.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003816\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003816\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003816\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}