{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00221GfoZIE8Ttrv8wDMuf3zy5hylyeKp7\\\\\\\\\\\\\\\/3ci4yLmIZiFCnW\\\\\\\\\\\\\\\/kFsO6m8iFp7bYkysspoYpwZ9zz\\\\\\\\\\\\\\\/BHlpzWcgOxPdBxtQizYRQV7u6q6JOs4HpHG9uhDT569r4fUhfyO57YjOrFzhmzUWovrU23\\\\\\\\\\\\\\\/EN8VQeBsrZ98GpWKvDqNxIF1t8nUXkH\\\\\\\\\\\\\\\/2p9wJbh6FwAY\\\\\\\\\\\\\\\/yBZGnQ8viAlKm5uCUTbFdW0qzt0HTBsBE1Vt2IOD2HTFSS983rZA\\\\\\\\\\\\\\\/2e0Jq3WMgEf2aDz69VfOLQhh+FOjHh3Njt85ItrudM3DzQ3klVHJ7XdJiwkAZZ7fm6h3hspL0hnf\\\\\\\\\\\\\\\/e5VYSIO3cRaJn6ryXBBnK8YQSlCRUPTVJZKgjaxrAMr517DQ6aR1V2JhgoYyE3J7At2hjdXbMEXpCxHWG3l7XAojUmGEybSv5+JZAGw5eUaaWMMlEyzRUvT5fP79g92156VzNJV1ePpvyXtEk6Wq25V\\\\\\\\\\\\\\\/QwUNRKUWqWlzqHgbKQ6O+kt6kS\\\\\\\\\\\\\\\/nDTMHD2YFOw\\\\\\\\\\\\\\\/6uxqJpjQl6k24ABuMHjmNo+U+g5fDZzq+roTM2JuHQIiy7w9EHhMtG00AK462+onPE73zvgmQ6P6ECCqjj8VVHtQbotNBBcy2ExxCruXo2X5OgymsHgx16jLznt31N4UGoi3Jf6geGFVf9FG1KqCUMNtq\\\\\\\\\\\\\\\/LcTFl3a3mn4BeFrM5EQrqYai48Vd2+g+dEm6UfZ8PvPpG4cbDP8h1F5fio9ofXrHOjkot7ccBmQrBJjr3EoS\\\\\\\\\\\\\\\/qHMN+G2bVpWGuXq7AYtjQvr\\\\\\\\\\\\\\\/h8CIM9sVY6SmL9tqg2Ar\\\\\\\\\\\\\\\/Vx3DAxPupx5quhe8uKGf1cXOGl1DCh4bm9JkqADAm1xR2\\\\\\\\\\\\\\\/FwccT\\\\\\\\\\\\\\\/hwaVeVOVONd3z55EQXbzq5DLVAS2\\\\\\\\\\\\\\\/PZmnpwLjJlTzz6ojOTLfoGMsQfmZ0hbh5v7Pg4eEmmmqS2fHiU77Tv4Wk74s4ia4L7W0Q1XSBCshCzUDXl2PV7vdkO74Ep2AjIdqqE8H2SHMfLS8nTXZCWfZFvQACdqQmUzmbVm6kmVgToTNOjOgCllwwrFqGzxSmAG5qQ0MDFa+3Bo5aaVgUqWp0yEMv5ml28bqOvQdqeEO1ipbc+GVMDxiqAHk6IhSSY9RMB7otSbuz5hp4nkkCtXgwS\\\\\\\\\\\\\\\/Sst8uV5kW+ueMTb2XMYKTWc4ngL2iPu\\\\\\\\\\\\\\\/oFr9mujnIFwzO2DMQhDjWXbrPk+V8wZp7Wt6mSECiIbSYOTeVqwPxcUgBL2ykQNM3v7UmKVJWIzqXRD0o7hmOJNhppUEDN8TboyQhPZs8MrJPbCq94a7LBK8RZ5WbJR98SLkT2DwZyLc9694svYvgdsIqsJxgDLyWJ\\\\\\\\\\\\\\\/CAdgqZ\\\\\\\\\\\\\\\/dZTV6DYujDP5RyOKk3Jwr7\\\\\\\\\\\\\\\/BCAqPUrNiJcGzyaeteRiAsCdyFdzzh9wug5UMY1RWLWl1mKVFP1kO3KcMNnPf7mZcET3hxP0GimkfXstHBy3+5Qfqbum6ftIbaxuQJdXB0OO3\\\\\\\\\\\\\\\/ImHWz1HMepSlCIt6mWOa31fq99Y5OQZENG4JFNO59l+7CE0JAElf3KlnHwjgEfCtvUru5D7qzSlVYbcBXmY7QL4ZOCNNBQ076qiEcM6+PQxfgJe4HVjRqCCUEJDWlB446qWsu73DHYhnS2PjkuVf0yI\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/szcQ\\\\\\\\\\\\\\\/jL+dWgNRoZKY2fjORezgmWtRVsdCwfKyQu8dzveL28LuB8tD3Rn6V7vUqXYdWneFq4PHxqP6M272SCCUzeatsoyD1nuX1DwbF2wgt\\\\\\\\\\\\\\\/QoCXK2AFOk0Hw4cfmquonlDi8yJiQ0vlNVMIEtcDuAyk0qxWYOfvrviFRYafCbvEFYz4GFxAtFhefJglfGplHBeD\\\\\\\\\\\\\\\/ckV2e3jgkULO1f7D6ILcN2Y\\\\\\\\\\\\\\\/x0scR3wXNFpb0uaUDI\\\\\\\\\\\\\\\/qPqvbQIvAqKgH8hTTb+3cS+EDfp947e9vZdr994gOv2dOrKe2mw5bHJfASBzZGB0b0Gl8KZecU0lVnRu2ZLqVPcLy4tXilN+augpA9ACfTXX3Q97sMHLPtAMM5enuZIZFGF4jRQtSe33n6P\\\\\\\\\\\\\\\/q35ebBRcpfCrv07+7qfVZnEBJ\\\\\\\\\\\\\\\/KmNBmEFaKHrrRWCRzXpOUlgHfa+ZyGrrhSQ4Pyx03k5Q2ZW\\\\\\\\\\\\\\\/c1Qpepnb8EJLTc8rgm5QK9JTfw4Gp21DLdKkfLX1MfZzOzlVeYP2sElRp+7yRHGhZAUraq7nOPcYn\\\\\\\\\\\\\\\/FhKUxRxdAxE3ugnqIJXe68pa3Ji+Vtgt+CXyTkuaPQWrtAGiRix0KOO0h46HqLz4v8XoYLixrL\\\\\\\\\\\\\\\/1s18QKb5tXGw2HVuh9p0ZVjAIk\\\\\\\\\\\\\\\/IHCgfv6EobNhLVTxJ8311En9\\\\\\\\\\\\\\\/3BNmbHlfzkVVvnirnsQ9EOJnQtovU\\\\\\\\\\\\\\\/gbsz+2h1Fy7x970IO5zwLPKfP7Ik\\\\\\\\\\\\\\\/TV0Ehr5BuDUlvi5hyy6g8wLWyuQtYfGCGaQODdHrdH5OcsGX22ukRRn\\\\\\\\\\\\\\\/W0UtFZevRuFsEcGTmEoAAoUAyqfPn3aDM6ZOxuJRcfeAYJ+\\\\\\\\\\\\\\\/sbjMKQB4yTRSXf32X23XRVBVsvlElZ9KtMa3a+tqwdMO2n7vZPzfYsVMfsJ7374XHvB2yIh06OUBPRtzTm0EIHD0CGcPEbPt4krQ+pedRkBOxdArYmVU0oev0k1MuqNpL6hg\\\\\\\\\\\\\\\/14U\\\\\\\\\\\\\\\/Z0d\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/lWuua075FcAJmEw3fup0WM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022hVQbClzjzlD8uf+vG2n8gA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f49a4fdb4246d7717a689bf2f787180bf4b22bd627d87003389ac9365489ab08\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e003490.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e003490.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003490\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003490\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003490\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}