{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022425LuM1ge6sIR32qsfxvxZOt00TjGuvLabPJVb5paaTrGAAqbtvVI3ol9zqLO0SoJC5r4Fn1VcwltHotoFe+MgcLtj7vkSAcE8iYRZ8GyOkUXTQ5wg1bffr64NZYx1TybyzIuy3K5+NKNFRN4z4I1s1x0OnOCYJqE7OgVQZCfnsmpRVo3PoRxdt2Zqk9JGchWP88\\\\\\\\\\\\\\\/ymesGMa4WOpuoskoB4Ty8B8d\\\\\\\\\\\\\\\/A5oz2xaT3Uj5uuQoBta71jNSM6EqLqv+2mAGvEo7DDQxUzrtuq6oPdqUGdo3l7OjH4mS7Hj+hvyjd3BZjUaRGUlJWdx\\\\\\\\\\\\\\\/fVE3ll5nERf9MvZCp8TWF+FV03gtkR4zRtSiAsJ1O5ZdogSeGvfqeSHaHXkiL2ne1Z\\\\\\\\\\\\\\\/k9iTJF\\\\\\\\\\\\\\\/VUi00BAv8lOD4v7yzHhYTwHX3lB8sXvIgV98hyh1qXPBOVQlXaGGxcXbOMVGF6f4po\\\\\\\\\\\\\\\/+x7ruCt252JuaNIXq8fJCmZk19Q2QtZSq4pFBybqFCYigx3Yz9vVwE4ar29t6Ku+UG0wA4yheD34tj5neP27ddOeupRAp1YS4phfeFTAyhDmqWlPhmLPZ0GjkXct1Ntl5m+iKiMKbl4OIkqeYAbF1ruBqEqhzw8zeo2dJ45tmbt73PINU9cNi7I9DXHMTwcPFZ\\\\\\\\\\\\\\\/h1RcUYIJmpCd2gx+M3Bq2jAHk8nWQER2ynhQhr57ywNo05NnLOBpMYlgkl13dJWXzkAwCEPd1v\\\\\\\\\\\\\\\/e4kVYDEdw\\\\\\\\\\\\\\\/ntV6Qbb2IZioeRcvS+dVQWCvBeMUlnjh8CaQcYlrr6KHTGXnPPsZ9ipC4lqGXlRAFjr8woJBTRLtxFIefHF5Fd8MJk2pfzNNnAqZ1YBAE5Bk3BpryZl3dJzc3\\\\\\\\\\\\\\\/ZPWT7bZmP3paNH3UlkNTUejLdp+go0eFH9yd1zcEUwycKGkT3ExwbsdJZ\\\\\\\\\\\\\\\/mfmPyKfuME3wVXUP+eW6oqmD+G1SfJ4zgbwCi9HdeaJkxVuXBu3cyZpk4CPm5bdkudAmi5OK667DqLTzsOH1HPZ1pUBYymUW5ZXUSLlsJEBe8W\\\\\\\\\\\\\\\/iimdOBLP64LfzgkPPfsC5ycf69HwgW1rm67sLbsS53ls1M6wAIQ2LoQSBzf9a\\\\\\\\\\\\\\\/tGqKrgTt\\\\\\\\\\\\\\\/+eX\\\\\\\\\\\\\\\/OuDwj3jhmzPUsUwyIJEc+wUJii\\\\\\\\\\\\\\\/s11dhZlI98\\\\\\\\\\\\\\\/S5e2ex+wKolUdf+TcdFE2Gkbp9AXPAaBy0lJtuQVCBllZDKpbKpt3W7WJaVdZY5ARora2\\\\\\\\\\\\\\\/jNL5FPsBeeh7Kc71NAWu8mrJqlOshPQOdZ\\\\\\\\\\\\\\\/eRrFGxQ2\\\\\\\\\\\\\\\/GF\\\\\\\\\\\\\\\/M09Y17PBI3rS4d\\\\\\\\\\\\\\\/vzB3F\\\\\\\\\\\\\\\/fiv4tnSXeLAKZ03zhFt3pqOavreSHV49a4vp\\\\\\\\\\\\\\\/eLdr+OG1yi\\\\\\\\\\\\\\\/TW0uT\\\\\\\\\\\\\\\/fxYaubmhUg10DMozyURdPky4wk3eYAEaBbglqhS+veEAQePkFvG0wh7rnQT34wq+E\\\\\\\\\\\\\\\/MuoDI0mOF2VpTDLHs7fibyD1vZVXpzHLoKc0C27vua5e\\\\\\\\\\\\\\\/0SNsaG6N42+0nLIlDq47wQDboy+ZTd5dHUqDjMeM2q4OS9KCjjo8\\\\\\\\\\\\\\\/57IghBtNFjaS1p2a57YrY7g\\\\\\\\\\\\\\\/AzoKFhL9G7pKEy643SrqQ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/q+9W8T2pUPZOguX\\\\\\\\\\\\\\\/Yk67UlJ8MKLGuasE1kNS1n2BTZdSmAfy2eul8CfacuDbl\\\\\\\\\\\\\\\/rv2xbvb2KjOOO\\\\\\\\\\\\\\\/yO5k3toyCE0hIkDj54m9Ia+8GJ1I6sjyWYoeHnc7vdNYrgLzoAWsMDI9yhTyZg6+567bXSVI8KRQf7u9heZ+z9a7PqPXEQX6ux7ZmIGKCCw38qSU\\\\\\\\\\\\\\\/8ytBZUs24ahG0IU76lls1HtlZnIyTxyIT1ag81LMKCT8ggXVVA93BoAtUo6SETeIuLaYhrqnYJz47VVFFDW2ky8k4CpaFXKAGXpTTx8M+sU4n3ngy3tQetJtAycbHhOnnlf1DhHGdhFP1CU\\\\\\\\\\\\\\\/e4oD3bQFwQhqYhdM9vScWAN0+z\\\\\\\\\\\\\\\/esuEzEGNBpk+Pg8jvkUFjsXhSww2z8jDVlZH9MKBPvCfm3O7E4IZBMBkHSzoaH4U3T0YaKN409KgVUGnH3w30qbZ0Dk8x5DjFzwo3SDOMjkeKkTSAvBtKYtnzVA7nC\\\\\\\\\\\\\\\/E\\\\\\\\\\\\\\\/OmSnf5HMUa+vJ86hKiBWwfNvZzYqp\\\\\\\\\\\\\\\/yc3RF57rUSkyU8fAOxpM2f0h3OjP31GGfBOfHQtdYRTernDh0RvRPztymtBV40MKV2bpcvdhpnUnYP7LigwN381pVrPQGkEVyKiGLTPOpX+z0Fw88xOPnTVn5cCqO7C1t\\\\\\\\\\\\\\\/l6JbF4R3Fqdk5Lk2++yh2Mc67Y4eOEbArKjhRIhRLyqUMMZzxx+jg8kbk3pF2W40fQYDZuby2Sg5fzOQOHs22NysKq7RPFCIjGq08j8fAFqXtpSUvLlLJrRtav8zMO0UrFS+ZXKxfNqKUMcRtEbP1ZAlk122Ps4bhschpg8xXPZk50PJCJt7CDMrqJ+TX4LkWMfrV+jQxUwrQryfuKDhRM2V9GActVBYF03FJkgXTojWLE6oKT2KwB2+uP0iO\\\\\\\\\\\\\\\/k5aS25vpbIJjpjYXb4gRVjdiigb7MWCBjhTwCvVUq3Wf8MAOHqhBzFGOACjKxn6Rxukkuyz0N6tBO\\\\\\\\\\\\\\\/KuRtFG9wtCV5VEuUxa8PfTLlICIQjcLcSvlUsJCo3MEBJvAhOGYK20XdgR0a459VOHeYk7zo90Df83iQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022JvQXpgQLWl1WKbalFyiKNQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00222e10297dded661bee40989915b8a53bed2a4a93323550700a837ec0f4484246c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e002223corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e002223corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;10\\\/2\\\/e002223corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-002223corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-002223corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-002223corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}