{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022uy\\\\\\\\\\\\\\\/ay6wIngyv\\\\\\\\\\\\\\\/jRY3xbxeGB3f4lxoC1OhIH8RPGSQQOmkVTVC6pixcYJMMW+VwYS6BMBbYgAbQO1GalKhNIkrX5CR9ik17fwDY94lzijSfr4PfiXa3kp8TP+\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/gcwDAOROPmmX10EqXV0P7Ht4b\\\\\\\\\\\\\\\/1w02Y5cCIJKgNTc42wuJOFCcB2EDryyyqdInyIJZ0IWQRne2WoD+XKXVQ3myiwwBaefE7lglKToVfafh0uzi\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/OyndEezkA58YU78TWzilXkdY2G6idjQmqfzEI0tCcXa4LmOHPLoejgRb3tvmOkCPNpW76ppSxcPDoIbmHdrxlPDALcCGKJ0xho7qsPP5NwQVvT7Jgk47Nt5mou4FZkr+suaLWa6hIkqqSx90TVQ7WXTtjRMHQFWZb79pf11YiFLiyflQPsGECXiUB7f2d5sb6R8Elsq8cq8jiN8Kt6ii03AX1sYpmawGFe3ceedOPZPaxLs2B8\\\\\\\\\\\\\\\/3nWIIvCS+VkBraX+hWxVZ5EDEFYmhWcSejA3Zy3+K2jjtLSCKSgS5NA+pMz5jMs3KoZ3r4RrnfymWMBsCO7ZGintSVCJ437luHlhJ2XYRzf0uzItZ5d8EAEcKrkkmd9J0Ynd8F5RvJcdRDCkVWq1BEbhgUth7\\\\\\\\\\\\\\\/ruDsUxwb6xkEFwgualbDXjmHCvpizN1gCqeIPcJMlXUwUaIYn74t\\\\\\\\\\\\\\\/QMPQJ5rNIC02ODYDg0qa1syY3xhEh7APTJKrBDhrZo2dC0mjaXdQWs4KTBWg+xO+X27LurRekO1CObDL58yh0Cp9\\\\\\\\\\\\\\\/H1hOEG3YNHRd\\\\\\\\\\\\\\\/QgYJr1thWKavu\\\\\\\\\\\\\\\/pi9WZxTqBKc+Gg\\\\\\\\\\\\\\\/ECjp5k3zM2\\\\\\\\\\\\\\\/hvBvipiXeRg8bi6H5R5+XfTEDjDJTJq1+3JxG1moBWK5lxBwb6FyIVbSEu1BSQYXJlSHFTqNWaqQuNgkYYdjeVcczUtwvK9RLrOmmpdf3\\\\\\\\\\\\\\\/f+OpwXU57oQQ8NsJW1sht8\\\\\\\\\\\\\\\/ESl4RgwcTphGNBDbJhgZGxlGPLH2UNHtd4jWKu3c5aVlZCKtsTERGlRCOmUhssvpKgxt8S9s4gA55uDb4f1h3p+vTRmAX6d1kY+OGfBVd4DtfMRWFbGImj6ZNHWSUHyf9Qhd8UE1DbutRZaRSTb5V3luIk5iKMAOWH+0KePAiwe\\\\\\\\\\\\\\\/VowbHpZtgOnRKv7QwpLi7bm\\\\\\\\\\\\\\\/1rXkXdNmpJWDiyGQi\\\\\\\\\\\\\\\/a3BsBLYjrK0PYpbK0W+KNgsBtDjcZ6Ocjl4O4PHpImoEDJnhIojNi8vjwy5E75sK2BBrj+buWcZtGpaBDqtmAx5JMYYLlPf6uYk4HoqlJExk3Mibu7Pe4ktKLba3kNKGNR8DgwsBFXezkgWWzgyniV9qjmNfw3q3znKpnpdCLPpoeXGNj5ee3qLAaWQxyzxmrfVtj4BZReCH3YYbjYCfzuQM4jhofMyBJ3FUW6EUto+WxI5uK19hkGDR7UzKZdswweojLzg3cb+QNSH0vKG2fHaUCVEl1TldYbE0ftj9T5xiHkTlZZ8D1YTtaIq2yyDyld2kY6q+cQJJ1OMrgrKDZR3L7eu1vNJ\\\\\\\\\\\\\\\/JIImt9VccuSfIoklX5GB120uyPxWJI\\\\\\\\\\\\\\\/oWX3ZuIpsUvT6\\\\\\\\\\\\\\\/ZnoTcSYqgeU5274n7OojfisrC2Sfe1i4bN34JY2szVQ6W89bvcvtVZoZB9BbYmQ8Iue23IlKzWESHnqYvUR8sCCBoPHBpGmW9T0avvVB1xNKoG1RezNunCaiH6impVJLEBGO6Duq373B62lnc9ZBYH3\\\\\\\\\\\\\\\/jmuTaBILa18+DXuv70wPYWzy\\\\\\\\\\\\\\\/nl4bnf9ol4IDURCoWOfM0xu51OkzgmMXq3MC4h6+vnX+bFJWGB4+pp5WIMhgn5VHOSCIcdUiHRUlUaG8CrmehQHQpIhAdG6fHOh7Hl88qgDVyCUsxgZLJfl4RZQSbj4bAOewacavLSDf5jCKzMMWcHUszW\\\\\\\\\\\\\\\/KNll5QWI1i0ETTdZHy5XB0nZ\\\\\\\\\\\\\\\/yegbsCUjBoYsJ1hwTqpFeCr1toD8Ahx1gU+OlYXEKzEqLug647Ocw2aF2mtnSzvkXI7o0DGZm36G2\\\\\\\\\\\\\\\/nqLGOxL5\\\\\\\\\\\\\\\/+CMelhzVHWQwUgNrHiI5bDRbzj6S1ThnBu21C2ZpocV3APLs\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/R5y+y0Iv2YGkVQjOVdGY0L3SUPMqhMdutBoKun2VcFyAT3ZASim8psRQ\\\\\\\\\\\\\\\/BsE\\\\\\\\\\\\\\\/V1XyhmDgccm0Mg6+okvZVE8rHP6DV32zH7Bkz8MJBaX0PDwcC30gmXquAcB01G0JuqRZ6wbQc2\\\\\\\\\\\\\\\/SJvKy4qWaTuBZb6TVoI1YVOG+9ka9fVWBqAf6fOJMwAPGDoOsbjbhU12ZbMYiQsztFJ+aavRNRt9k8wguveu98Q48NoKXDytnv4YZu6plz3f8Zp7t6RjE2oPOV9RBj\\\\\\\\\\\\\\\/iltHilc1CoqHsb7IqgrOgvtkEGE2NBT5zbIHKAmdf1gWFWmq92iR55w5Woell+vgHxyRlmFgKZ2VkW+gzylnwWgHO9efu\\\\\\\\\\\\\\\/ZeOENZNg9r5XQdHdJyB1ymijJCmqcSIAj\\\\\\\\\\\\\\\/GTaHK171LUrgRL\\\\\\\\\\\\\\\/ssqtMcoCjdJ67UvhjxscmC8oxLP60iVdCNfvev+POgmr+x0xdyxF0g12y2M5ld7t4ylrbHMpCcsNmVR7jjcJkffMm0X7NIlQ6owDHAovSZ8PcTqy0g6IGEYtk25jyIcagaY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022pqxVrZ1iFzMMO9qwote9Ow==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221cd20a72492d7b9bdeb52914b1bc68dbdf0e1d88fa08635f989d87a33745384f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e003465.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e003465.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003465\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003465\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003465\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}