{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022aGKrkvqCVzT7flwodWue1b\\\\\\\\\\\\\\\/QdYHf8oVTepVHJe2yTgv+YNva03R1j+jvQBBB3gNxWDiuF9LQjVg1CL1ggjeQdOcNvrgb2pdpzAxY9qc7SLEHLsfejYJWisYgIZYlR6euGt6DZtC6GV7BJqitT6YYVNu6\\\\\\\\\\\\\\\/ZhXhw2IdPQ1Y8akUJisDkC+kaDb34ZK6PQbKTh4rNkC+oCykPH4f3K8hLnThBV6aPWEkhMYbsQi4L5BrcW48Sv0KPmT2iDa1UlemrzrnxaaVx4fcxHqEzJGxfrZi5Inw4aFsNpDy+15FLAUqOgsIss6q27TZsMwV29t4lECHsQg\\\\\\\\\\\\\\\/MJ+2sNYtn417X9Idsn28vmhl0ZtlANqxkdt+1u7TerbncQaSbp\\\\\\\\\\\\\\\/t\\\\\\\\\\\\\\\/I5+HMmoVdsvdU6hWM50GIgKi+tygCXKCgQTJXSPInrAz8eFU7k4OuVdNhui7pgXVaAXlq1Wx5trx3QTixm2L2nRpqICSaOG0YSvY5Z+S6LDXGP1nsPyUwR1auI7g0WmbqM\\\\\\\\\\\\\\\/C1s1VNYU6btVzm0g3exXGDyMKbWlUuq3a6uIiFFI2KsOQ9bTtUa5FbCiFiLrVzMSDm34qVNnOA\\\\\\\\\\\\\\\/f79wGGbuqJd8M+\\\\\\\\\\\\\\\/l+CaY8eaW+p6zX7U6QLVxRxtCuV7Xn\\\\\\\\\\\\\\\/39T\\\\\\\\\\\\\\\/evJfsTQq8gfjrHQiAq650Sdv5Odw845JGhwWXuO43qXyKHj2G5OlfvfVQCXmkMgohVzNj32XoaMuYZF7fw0wRKHTLVWqGCX9qOn7+S3dVk3IcH1hO8PdHrxXzRZPAlh8WGLGfJe3lAiITJmodPa7sJ5J+Zr9tCHOHVePOLQTyY9m9aZ9fHpxc5ChSEHuJJNkbMxILNec+fmcmVWpNIpKRC1QtYtGtmVsU+K3zSn\\\\\\\\\\\\\\\/0L7u1p5u1MO+nJCvCL0FMLM6QPBz\\\\\\\\\\\\\\\/dd+\\\\\\\\\\\\\\\/TOjnplEVt35T6cCstBA1LpAVAeEFGDbZ4GB6pgfq4XYZ1KeD8+uVKWcg8FLcTEhWh6mW+GdgVK2tFstyrs40f+Je9v3A2umEU9O7FynNOZVP4TCyUZpz3dPdDXpkO14YILiKkI4N34ruFJEpCyiQSP689\\\\\\\\\\\\\\\/GJ+8R05nxGdGyJIpDfVJA1RKNGCDTBD4G3eERU76pZvNPuuLfzdk0l9CU\\\\\\\\\\\\\\\/8280p436kO\\\\\\\\\\\\\\\/M1puB8RJrlAA6YnLzFXyvSCF+4PuXlhEadSPTnP9BIEcQUu\\\\\\\\\\\\\\\/nbFRuo0ctvJzdL6BVaH73eP3biQY4FM7riWz+1n+ws72+wLcXihDYHhRVlZGo648x1d1qIgtgTWq9juRr6voZQ6E18EgAqZHoYPLpM+av7JkWbX8BQ4Ypn1\\\\\\\\\\\\\\\/iZlIlqQUcwh+TpofhKeZVD8rv\\\\\\\\\\\\\\\/UuHDsGQDytiPdPjhpi6cnfiM80t6GiOI7eUPJpAGaQ5kavUtuOmmF4SaYtA6CM7jNqqM7SvypsjyqJQwYG76PZuTnpWswh8GglryeYYCuVdIrYPEj2BhUALqGXZbTq5oIAA6PUCvYMnzLvkDTpEp\\\\\\\\\\\\\\\/QYfG6MEiRPdTOK7WLtaXQNJ5\\\\\\\\\\\\\\\/eCTOLj4qumqC70Jhcd1FNZP\\\\\\\\\\\\\\\/NufcNjcoHhSSsBAhBmOt1uMzbGx1RkKqdJA8xLFq4J2icau0eh5fzr3NV4VnEnXWqT9BvpfxhK4KPqzd6mhfZRosT7wlg4jgfTas\\\\\\\\\\\\\\\/e9+K0dyrmNxhJJBQY7FoxKLT3GSWR1k7yqePE7n351wpatHVGWC6Csp1qZGOBuH0eKCXUOM51HDJ4VSToN7WdM+KxpbSCOzG5aTUkHCOx9aoXudXfULBgWBBip+ETEiQ\\\\\\\\\\\\\\\/JH7cCfOfeii3L5BJQiPKWboFdqnEcdIg4p4He69cLHaXjQhiwk0UBmS7bG9LIXMl1nkUQ\\\\\\\\\\\\\\\/4Z+VkoAFpbJItRLeSQDk6i9vxF+\\\\\\\\\\\\\\\/vm7B+fXFaCd\\\\\\\\\\\\\\\/3C7Q6479FlTgWZOuZQDNUhKMD0VfHznJ34cxkq37Qlksw2uxTM\\\\\\\\\\\\\\\/J1Cm7CIrLesboUZwWTDmkaJOGX86IQyfvDm7dHDYQWO8fzSs7kI0Bd79JCpWiO\\\\\\\\\\\\\\\/h\\\\\\\\\\\\\\\/3L46UcGuMCu2EQmZflHZZpGUGVA2TYUB3afrWVeZYuIx65Y2OxyHEifnueOUXeyhdP+rbrAn68gztVoSvOrIPQDvk8YDQr1Wt+SF5iOenNSTVS5T78hJleKNlsoMwexah6I7DIBxp6Yi5+NCnbaA1Y3nhPeJv9wJN4RxMO7bi5gIgO8rBvgDiU3AfGN9owWZ4WBk+K+5Sc5U6rVPfO4uAv7CcphvHpYTbxpm7OFm8JXTrd9ilIDhh6377wp4fnNzeGOhId4wQruHhG4ETBmqJKCiKs4Yqk2WIDNFllrbRpYTOCCW\\\\\\\\\\\\\\\/C143rWW+yD6MeaAGATJ\\\\\\\\\\\\\\\/isAad67KX3NBKU5bG44k33ca0fBAXq2Uoc9IOryL5amycu5VT5oUKGtKan8ioIuEloNLYos\\\\\\\\\\\\\\\/u4aV2yOl7yviLAJKuJweqHyny2m64PDCEyWjmfuhiOul4LDXeECNKCT\\\\\\\\\\\\\\\/mRp1S3vWmyGzBd3QChQsQe73bFeubqBBEAXjflitar4RGedekXXt4dnKZMWHgvfOw2XqXpVJD+QH+1dBlOPBtSfbSGPxfKre6H4oIas92qWmIdZRQA372LNC6eN4qsg3RYtGIFv9dtN3WZPzsPTebD4IkJhwZfrxkMeQET32FE2bh5AMr3k8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022JDCCkDp4+0koZrPFXYVF2g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022660f3185a7b4528d33f573217ed27ab6fcd760ce73eb7d25462c108842981876\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e003382.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e003382.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003382\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003382\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003382\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}