{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00226MSQRt82lre8Hv24VzPjXCrBCc4WHwlnl\\\\\\\\\\\\\\\/gvMlUHDjtckfL4TbJmDOGQmPeVBp2XTZsbfMj1yZYTI9p91gbVy8DNjjUhiv+uOcYCutKkqj3ynfmEqXMXgmgp1akFcBZYhRUhAgdY7xnDoO7vwVTWawRsuop4pPzx1rswzX5QGv\\\\\\\\\\\\\\\/wDEZyTRdl\\\\\\\\\\\\\\\/O377TPz6y0aeAHRDTGgyQqy0p\\\\\\\\\\\\\\\/8FOYkojbpYzPZKq4OblXi9x7Vk9A0pT6UjfwldHyjfBsglc7jiFwAcPZi4Lb8zqSh4rE6FG+dhXtg2i0s+Bk4zykY2+DEvpXEI8FVd5lRaeejEzqRgsWBfzhoFU4cmfeOvbHPIoOoH4YQiMo+KO8A0EScXK7+XKhPM5X94G31UsJb2dWDWCAK3k5dk7D5nzpGlqFTBUkY6ELi86w3gLkiZOYyEvEymNRu65QgUZM4pqz3l3Y06HiY8iKWjABPmzgVE\\\\\\\\\\\\\\\/jUGkImqfzVyWX1X6TQ3rSqhS1Q3+aRhTESEXkP4zOvrBMTO6URoYzm+K5pduhHxoxaCeVVqHu55\\\\\\\\\\\\\\\/Li60pnPzztwzx7gO0VTkkD8zOZEYlmy3veBJ8OBNSpqSsr3llF6N0hCFXcT\\\\\\\\\\\\\\\/xWO7X0uchTmaqPA6b\\\\\\\\\\\\\\\/4UezZcP+5fwTcVC1\\\\\\\\\\\\\\\/GjOukv9SxrlwhK74dArMNIBIXQvUrcvILZeRYBd36yFcaD0zuM1JZ8F55ETo\\\\\\\\\\\\\\\/XVy\\\\\\\\\\\\\\\/+latR3cdPJbbXZGath\\\\\\\\\\\\\\\/wJsQjrFHDU0UaXHdWKJa3BdOsEOj5kAN\\\\\\\\\\\\\\\/D\\\\\\\\\\\\\\\/SY7iohc0IUBzzXbg6255cwW8rZLuYYCCY\\\\\\\\\\\\\\\/KFicQ6W5Hw5Yvnidai93MHsaf\\\\\\\\\\\\\\\/fbo+JiuRxB4Tm1xRX4lSVfj4UAJpPoFvfG0eIw99c3je0x5DVlrLxvRcgG+On8GqA5MQ\\\\\\\\\\\\\\\/hGbS9oefUvbVbQw7WhB8HWjiCcOWmxyrHtE\\\\\\\\\\\\\\\/zbfyQ9NX4Nt1oKFbEam9OW8ibL0d71tx9P75lzWz1ynbx\\\\\\\\\\\\\\\/nH0\\\\\\\\\\\\\\\/YREkqhECP59199sA630xOQvEB1hjcegBZgb2OzgMTq468fDglL1s1kdgUpz1JW1BdC332A\\\\\\\\\\\\\\\/MjBU2tTJxC3BpPe4Q5c1u\\\\\\\\\\\\\\\/NCtL8xB7IXfvtSOr5Gr7hkfqBScFa6KlRynQn7h0dRlGaTWPn1EeM1fXPsUoHt0Tz\\\\\\\\\\\\\\\/PY7Ic8uxCB6Ah2N2xMT\\\\\\\\\\\\\\\/9wRyxsAL532DJXA7ffkbrzofA5Z6JWJmDb9LhDhTrswtqrAwJTGgu8+ndjgLQ2bq4pzuUY6pcF2jEPJUrf9w4WmPZF8++Of9MMO0Jtcv77drXXbL6LBIcnUcquDUMBNJEPz9ugcoIqn1kQZQhcCupXHw6wh4LH\\\\\\\\\\\\\\\/aAuFVAH+xmIoTmLMjQpCeZIjS1m4StqXv7rGLvMIHVKkk0xXfxXsrrfXFOwGE\\\\\\\\\\\\\\\/4FeuvDb839CyNsaMakztD+QbP6ayOnr6TR\\\\\\\\\\\\\\\/IjUqzyDJFRqjIVT8j50i9qq95ILhTBZMxemwEUVfTKw2uZh2al3VOACQWKhVBIzCtjh1zbOAFdfEgMOZUM0p9MsQ4mW4AsNjAsSFK9l5Rs4T6PdTNkleMmrv25mHYIiqZW4+Bvm5X\\\\\\\\\\\\\\\/dUUHF439jOx4hOlTEL830P85i8zmUR5jo3J3S7HgVsiwm3AupA8JVgDAaYYPaPttdTvG7kunoNI+SJMekJ5qSqL7qsukHL6ekIKuzqgCu2uyO7NLff++sKcxL7eMHGqfHlnEHw+1gr0apSQLSBItCNlCbcZPbHDfgHGxG84IErLqm9zQEcn4bodeOsNjdf0loVnCj9jXj+VAsYEdr26oFuehzlVasdgRo373XWxa2sH4b0NGUlWmJY\\\\\\\\\\\\\\\/hbUFKTa2WdO6M34XBCcBQacQJarLWcwKWOnzuXT6njs1fBaXlNczXBLfh3ou3FeStDjoBqueDtyDduT1Hr+bFmLF\\\\\\\\\\\\\\\/vtYM\\\\\\\\\\\\\\\/wF2fObPQ9e+dh8wykQ8aGA7L60f3dYOo9GqYNxmpIfLQ5nWhR6RDLW0OsGpjV0p56BpvSmoAXPlkhNomycKqolYvu0nuSQ0nCV\\\\\\\\\\\\\\\/RPhUKQgXODnnvKUp4Rv+n2BpIUDZTryoANaFbpCxZr4ZV4UgOLKxQM3r0PP1vSDPoGMX6uLzbT1FI6J4gWIukSO4Oh++e\\\\\\\\\\\\\\\/h0SKShu2ovWiZ5ZwpE7SoHrpPmjZhl7uwDqH50+5Ew5N1WQSbnBIIIwykEzwPprgrrCYaCOoWm7iwO97Fkmk2dg7CC9Rs59ouj0MgpgRTw1TWy7Z8KxkEfFyJ4Sy5PtDWs9A0U5xbmp1r+GkGD9h4pw0jWLQdQTkvyTUdAl7Uw\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/67SNjKJvf42efOvJxebACL2LwuJYHgcnPa3YHfKvDV2dhR3JzCgt6jtyzcCb5Si6Cs2eaWgbVBQ0wFCNBcEBC9SNlAS3PyEFcVbbHNeOpZdsLCatEgsupikUUeGciNsBp7lyvDSjH+RSD3igsKClskz2QNgJfCK0BzHqGDWCljco6Y\\\\\\\\\\\\\\\/8K3d6Bab3a18dd5\\\\\\\\\\\\\\\/1wMgiHDI8CZEfI2trZoxIhYDD9Apv4TmcDRmQ6Cc4Sx8wBxXK9kt78eqnmJ\\\\\\\\\\\\\\\/BNMv3VwTCg4Mpqd90Rv53WUvCBpC8TEix++ir2glV\\\\\\\\\\\\\\\/85KDvcXVZN8ak6x++oNoOf\\\\\\\\\\\\\\\/Bul5caQHCOuHR9ke2YQIqXl38IRLpJ14OIpyY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00228yWhtJgZLJTq7X0CMOD0lg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d537debc6f4938437f5fe1caca46fb5a1314f8c2ff9ec07892561191007c4855\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e004001.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e004001.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004001\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004001\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004001\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}