{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022hyWI4hKiDf8jCqo+VR+JWWZZrZWiViARMBFuTaRXxPaGcfHEhUQ5kqdlrqdUaGDJPORb7Eiz9nXW2TUKVMtxvCJppeQsPwol9QIh3x5+YBPH4dmo1E5A0lu8XtWyO5lt2RyPfWZugMNQGG2aZYPfDzMzsRqbzxDVTyDcZJc40QbUOB2BqBGuuMA4mFcMRSZcyqrRXphHpOQ7o8G7rOyAN2tjnSevso5kNrybrF4OHwZqQ9KvZ39bZ8koGp9oU5VOQqV2ooVZo0xEPNIAnp9oAbLcCGd5iwSjg8aIUbsnUC0lKJLqlpX2KcFLDPVWk5euH+CW9AVNr\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/5h7jfhedrM7fBVpCzcC60sENTl3yq0rU3+\\\\\\\\\\\\\\\/H0ZO8HAwHmd7NxtCr83iVF9G6VL2hOlQcE\\\\\\\\\\\\\\\/6sGhFPNol7foeyWIlONs42pXw0ZFXbw1jf5QfV3mT2+4rAloeymel1STdaHRr7DitENTTdiXKPnqk42JnKx39r\\\\\\\\\\\\\\\/YePDe9sacXpDdQpkM1SrDD3R0IYHnl\\\\\\\\\\\\\\\/WkLUahhJ+d5ZgPILr3mS58NRG+T1fSEDfnHhKqniA1Zq4PTMhBXA\\\\\\\\\\\\\\\/6QE7SrsZmQBrApj8K7m3zSrSyXstFFMT7EBWSy1wBBs6Qu8kFGYZknrTyl4CqF2gOaoVRliftvr4j1T80Q16040SVcDXGsCCBX4zbeD2\\\\\\\\\\\\\\\/hvEMv+xrq3Dlrd6+7Nj8wTxr0ui19gtV5adizUuxhlklMZ\\\\\\\\\\\\\\\/O8xIX4gcVspTzzTnNUVnWQc0IAxBSpe4cAhNCK3uPH8IbGtxTa1IHMBMr5qftltDuX4AB4CXWuyoBidKv095dNTxKr0qHVoBc7BL44tV6eStkz3jUP+dtfPxX47ziXygn0Ag0p\\\\\\\\\\\\\\\/4dLCDq2R7U7UQoubaetKAR7WWUzwrOyAHmSwz6hEsyx1vuPnnxxoaTllQih++ac3umikhwB+umq0Cjx44p9Fq3TpCCaWDaXzdOGUl5Q2ciPdp6eJZfU2L8Lu4N1qGFD17ktC8hxROeJhQnWg6FC2JTV3nZdKjLYMDzuVNew1Qmi6vKa4tuxs2Fpc+zT6+aIUD8tWNhIFmffsf9Ak\\\\\\\\\\\\\\\/kUblc8NygqcNt1xLNay+mFeF8ZamFrHEGCp2Ni6VvpHVwDeJcLRQrlRTYy8QgRRBlx+VeACz6kMyo+itJsFwpfatY9a3VOCReedFCTp8izCcnOawSMIFlSQCOqzW6mA1RgPn6K4ECYVr7UuccGw09P\\\\\\\\\\\\\\\/FwNpwKpOCsdOGR5jL6zM2+89+Xm6ezIUkO6W7yMPDxP6URoOP7\\\\\\\\\\\\\\\/2HPV6r0znr7EGKMSsWdo\\\\\\\\\\\\\\\/ByG8TkuqXy5lUYaVMxzVaallFCRBJkS9nx2y0tLIJWZGEfzHKWi9jkS1y4rvmmE2mYaANfnpU1EeD2fQ6BJ84GlN4hw024omYanmzG8FvzcpzRD6ad3qgSukVc\\\\\\\\\\\\\\\/TMufSAbvETkJB13ITOW1rJpFmtRpZZcz6rS4tx1\\\\\\\\\\\\\\\/f+e3zPHy7xHtf5F4cHHEB4dqOLi6X4+wt8DVv+upB5A9k4GcYiCV2JyMXUQcsSRmNqxM+PjUGmrrXymNH+h4jpFVJ+Xm7kTB9dK9pdMKoJ0QUvmzTpDCln94XgxFyrv0hgqZm9oMGOWLCKPOMQW69FdP+GfWsMzxkJayKO1Hwxtj1bIfWtT939DY4Y6iU9KkwSf7Z14AuwV3bVGMjO1ojmUYqUoTVw\\\\\\\\\\\\\\\/upMrqqSKcB8JErSnLEUWCX09r\\\\\\\\\\\\\\\/xaeIx7yyLKxBNIK2Uk0p30FBJ6qRTSavy7BqfVpkD9G9RHS+ZtsUjBK3x1I4Mu+nBwNVG9isaRtuG0tDa9FVqabrYYp0KMIxox67BIYHvoLZG3q5qKRSIePn9wg3Hb9kIZd2atR7yKI8z0AcryH1mZnZTELNyzyuhJqiR\\\\\\\\\\\\\\\/BZVEhop4id+nWe+F8Z+7l+XloIssNf8\\\\\\\\\\\\\\\/0nhcflpHdMBejYlUJWDa2Sf+1kBPQIg8h05Db5emHE0Pw3F6tzOUJOwwsgpIVg0k+q0OgjUWC0RAFMI+uqusxsk1DH90DKdv+121yeunUw2y0HyDpcP099t1R4Iy3w1ZV8R05a6NGGQGjq4gcOsFXGIDAcoyawHt\\\\\\\\\\\\\\\/yTvnwQ2uf9ftsKmYNvOqAsZjFtIvAhY8GzmmCZBUGA8BLbYiVXtBvHEjNOCwt0WSsN6A0Efc70j7IXRPlbcl9i3CYVg1X7P5BfGIqAj393KEbqVecX0LBxj73vbXkvmq6i6NX5nqrt9t1jYKcKl9cOg4woxjxWZYLilVcXSNW47\\\\\\\\\\\\\\\/2w4PVNJjfcjqGt2+TOMSsZ5rIl\\\\\\\\\\\\\\\/KKu9pGtNvrQH7RID8moXbUOrvExW0b9IFbLLCmnasToKCoDTJ1QyBCawcIanPXFfq3bsnDBhGHnybURYrnLGDXFkf+IyrM09pAw4yl1sbpMRZvQvmmOn1Ky7vXI+4ELfKIfPvF7Y\\\\\\\\\\\\\\\/NiVrBjogVqokt5suQE0DQoMSYl7th0OmwA3nwB1HC838xq8ugb86iH4+gP97\\\\\\\\\\\\\\\/jalGfp8nuJNjI5yHMpuSTC8ShqQx\\\\\\\\\\\\\\\/Xp0f\\\\\\\\\\\\\\\/OOcRzZrEXNLgL8A3SfSbHFCfPzZ1aDZKNcEYD4zPdQbmu9OJ1qb3nMnShfctY8qZrh0gixcRHcKDzRAN0UbGR\\\\\\\\\\\\\\\/sVfCSVCawE3qcqVPGHVW+gyI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022bNa2aS0s2AOSRqGAkPRarQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002250e0ec7906d0d7b5ae313816a3bbe962b7d252202b7a9916ab77b0f750a73b9f\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e003625.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e003625.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003625\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003625\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003625\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}