{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022n9SjAEdTXGSOD9PmHbmh9DsLS\\\\\\\\\\\\\\\/4J13HaMICskhbmoT1n34XPuG7\\\\\\\\\\\\\\\/EySy1c6DPcmmMQF4i1yM+w3g33yl7P8jFQg5NZRl96lyVUaBm9ripCDt\\\\\\\\\\\\\\\/qL7ccCU+Fm\\\\\\\\\\\\\\\/CRhwtgCihCe1ewmCvCYbook6wOk3ctpI9perKQYvxOmyG0iAiwxmiz3FZHnSj5xjd33+6gS7d8MPwMy2CaVO3VH8pG7pXjheLILPCGcWcJJjzV8wBCVKaS1uBaCAonFj4cfC1VdIcPmwwcx1BhCiF0Xkcy9ugy7m8yclnCgYL5k\\\\\\\\\\\\\\\/D6tTSU74LtyEJxx50Fa61uwBUCeIarExhzMTBT0cVR1x0TotJFIBJCEmB2x5tRFxK0atUp03q90d+xTGw0uXe7htB3gvCFtJg0L+jwXVUa6X1hbg+E7hInYxRc83jY48lYEd3LsuqZVK5qfWi\\\\\\\\\\\\\\\/w3sVJ0E7XWWp5t+eN2ATced3wty51Nmr0RKMVhTogH5716u5W05eDt0yZ3WW2C+4JstlEou+ahGZ1hGgH3sbICLQWKr+7ws37I0m9CVfn1bDeWQghfi2+5Sz+9to9wBvsqYBS6VIVBPqGBRxMSHyvW9brkYs9aor2McO77hWFez2uKyhZmBmf4Rv+E8slFRaOQBVr3HEVgTBsBtfdEhLoFC42IAAadCg6sPqew9IJpBMfLM0zpvPCt7AMi3nf7+QvqlMLHBimdmBIlV3AURf2QEcOXGGliZX8WlJl4k+epED3qCQZlV6ThCx3MZhWDvvqYhnIQt2u7w29SLcfUf9wM8s\\\\\\\\\\\\\\\/5P8KiZxpMe0wZGFKuW8jPKdJHHKvPgZYHcerxURG7L+qsYVZ4aW2mh8aucqrLrB97zAZ4pJmsWJzumNKDxbo9Gg7hoKgbNqJUxw5wAvg89s8nQ8LpgT\\\\\\\\\\\\\\\/008pn4lbT0ySRa53xvvn1uZsYB+UBNw+ZN6oVo6fbk+zI5eAZWSjnRTMeOiQLwdXFaY\\\\\\\\\\\\\\\/KWK3ARBEUe8ixHEeFPXaAku3tSpp2Q6\\\\\\\\\\\\\\\/LTnqFU87pATlOMaHVxoFlR2FmhrWLaCHW1zgC5aubss9Fv66f4ER7GP77cxarv3IFXCMXGT9VuB5o1f5IjEZhJ+HxfhhkNVxsfvxvv93PmJS2+na\\\\\\\\\\\\\\\/58SX+Kik8zp6f5yqiCHMjXDr0NOuZW\\\\\\\\\\\\\\\/Mx\\\\\\\\\\\\\\\/SM0+h5431\\\\\\\\\\\\\\\/hal6ryYGOfKI+fBwWwpLEff+wQ4Fh1JWh3tlG\\\\\\\\\\\\\\\/2+K\\\\\\\\\\\\\\\/btOSyBJKNcyq4rwicuz3Zvnv7fTVHyDABoUhNORzf9mwqlbtL9fb55Uw2KgFMShOAZ5YxvJ1tWqD+hOHoN78g8pbxVp8eoDS+NmyADtSLPnNAIAYT5UH1Wui8v6Ix23tDD1elb5UILFfmOA7IXElxGZMZQPqP3jzEKDIbgarzkYlIXgHGNCGxMUBfGR3FYnqfnpGLFOb2YTy+ZbS7ymSTwwacUzVtx89f+khkyrBgqoxcN3Zqz2aPa1WARKL3u2ma31NPGQ30e6wTys9jGR18CdYPoYQos\\\\\\\\\\\\\\\/ujcrDodNSrx+\\\\\\\\\\\\\\\/TsaH1XRcTUYoSCcgAs+XyYFsOsItgrcmUQ+y2KZe95PxpFagH2r05efKyo9BmJi3mCZzX3tTveCdetYEtyAei1WBbz9lk0cQKvyiFARcmmixENA5Hwl9y86Yu7xx5Cr\\\\\\\\\\\\\\\/0+bTIBvz3n\\\\\\\\\\\\\\\/Xq1DwGHYqCs+Vz1fz+ksK7YcAQO4YrnlhLZwYRp94TQvEk270hJn\\\\\\\\\\\\\\\/HXr3g30PpPEXmagtl4bZoz35ocH\\\\\\\\\\\\\\\/+MsjeFdDNq2PLTct4BJQotpAYYxC8I8SBVEww1HPs3pY6EYSoryZyzMu701ENhyeAOFmKbWnqU4rKKanB84vXyqI2hano3vEnIVNnbdILjdP3DAVoOu9jQc4db37VsLKcCrhCG\\\\\\\\\\\\\\\/fOmjWDQbbv1DxEtTWV9V7YKxqUg3rF\\\\\\\\\\\\\\\/heo0vTJnlR912LgmbZId8VfaJXp1jsYDgQSSumMialvt\\\\\\\\\\\\\\\/UYWp5VHOCU+o6xJsEwxUmTvyUg+62f+LGnB6qW\\\\\\\\\\\\\\\/tBGFHE51DMm71IUqlBMyXLsYyWNUs44msR4qABPz\\\\\\\\\\\\\\\/zp5rjmsZ6mqeANyKFk5qm3u\\\\\\\\\\\\\\\/2MN3ZpEbuCt9RCYGVMLi+Qd9iXIjyAMHC0SfM39auZTDkDkehkJSueNewwFGqL2HMwJWCeQMgMUsHaovfkNfqkZYlFDkxArF8gTKONSMuobY1gHlyFJ37uRgkd7u+Zyg64V8WeyoMjcJTfdNSk\\\\\\\\\\\\\\\/7m\\\\\\\\\\\\\\\/plr2ay5RJbV0cH3ZKqdaFXsevjcalHvDsvl+bEq+uxK1zwn1dGDJ6GzWNIjh6iYDUaf7ngG9BDkKuadIV2OsvqnuAnAH8o6CZN5nsPmEqWKCFnsqZ\\\\\\\\\\\\\\\/Qsdjah4FXPFANE1abGXFPrCSR49KNJFL0KAvV7celkw3Igu5T2sjaTk50HduiUZcVkkxT4NXx\\\\\\\\\\\\\\\/qaQmqA\\\\\\\\\\\\\\\/aqegRfLiLMiC5eT9NNNBAiDra7YKameYrild414ahOI0zOvclmGJT1kSEzwefYt4bNZswtZSVrzneaY8mROEO9zYNZuxWQvPzsRqc0zdyu3EiOZs1\\\\\\\\\\\\\\\/8pKHBHOuOpEYZeh39eyOW0fJbhUN58YRBU3cXUFIs6dJPK2W\\\\\\\\\\\\\\\/SIMghejbM1eE6OijbU14TgfUqGSLQFoBXfJkkiII2upfRfGxEFuJuLRjTskDqA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022YN2wS2pbeBTOzkRPZdkuxg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00226abb96525ef877a8ae99f74b0ff5000cb951379bf29b5163d66c62c0f34d5321\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e003459.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e003459.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003459\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003459\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003459\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}