{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022RbIHHG93M2YtfUp8OuYWphy9Rp2758H\\\\\\\\\\\\\\\/zHLDIjodTPjXIh\\\\\\\\\\\\\\\/GTpFU6I6kenCH+1Fx1uNoFMX3ICzlV9\\\\\\\\\\\\\\\/4X+h9mVV9Ac90KIOi8qOgSOrI9zJyxFXb2D3S9eG+A5X\\\\\\\\\\\\\\\/FwSdiJ3FPKPbgvni4wiFnOAeqJkflXqAd748lk6Ubr0dghv3VO9iAWvawfOlGz7+gPD8LSzmNUyVGr8upV4sSziz9Fofs8JS8ER0ygmT7D8XlFbUYmbzEyFFSlJ9heJgENuyA54rzYJ+N+Ddwcig0I\\\\\\\\\\\\\\\/ZNrPKuBWUjJpqYr6YA6EWopLFhOMnMnHeFuZ3ecfvXRjoNx\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/9nTXU0fAAaPpeuUmBeZ8kr\\\\\\\\\\\\\\\/gvaHsuNJx1DBLZs1ybGpMfj3aWRQl0sTic+Sj\\\\\\\\\\\\\\\/8ClTTNzILXKksiEsZ2WJi00OmYMv8u4AdhwxvYBYTapKyXbuMFMKmRbnCaUgryNKiA1MCrOQI4AnFIRj2FPSYIyaHf4jUtSn1ekGvkE75YFxQFJIDCte1xs7zzvxs8+M8k9yDb1lm5CD6E79qBUAL\\\\\\\\\\\\\\\/+h5B3Ohf2F\\\\\\\\\\\\\\\/Gh6WziBwX2Wxx\\\\\\\\\\\\\\\/iETnggbALl8vH1DJNIt9A3V6JMy9koDf3IUDI\\\\\\\\\\\\\\\/nTq18musq\\\\\\\\\\\\\\\/pZJ3Sq4jh97XhUDPmj96IwORYx55vt9Dr9nzte6bSrfVm35QmZzvPOF9KtLQB+nmBSK4taZubJMY1J9z1TUXOtfmfKwiF2kKX+m7WvYB68\\\\\\\\\\\\\\\/HXTFIFQkyqIJeWfJN+Az3cemHgYn2fgc9S9q7LPGyzxVw28V7Q98j0609yl23+sT1gu1Tq1QPxqQ0ESXT9VtDCXOx3krsRGde8xBP58j3ucmRMpqlSlrbq34fFui6eGDvp9IUBCjdYCrO90ja7H0uxNbYvknWyb69xVfdazxzGWlH6Np9QL+xVDqttrJ+HEqEEcsHoWmXvkZmA3yRIhTTxPI4NEaRhgHcyQWQ4I\\\\\\\\\\\\\\\/6u+oZdsAQNZB+14AkZsem2VjhhPQ5r+lnCxqIQf9saaWktDGj2l9VMdlpLOGcAYPB40FIQDWkm602CAwHiKRNDY+577zWOMNDRmmCvC50BdaGEiRzCgQa9XyPPmNFxe9ru74lLLsr1O0grbKMAHFpSh6kSbjBDxsTM3qU4Ia4jsNXuuDQE7OSgbtjC\\\\\\\\\\\\\\\/Nx8glqeI\\\\\\\\\\\\\\\/6NswIa4jxSLxCBkIkgbE91iNm5K7Z+bk+ggl4ElBwx8eOebSz+dxHl2CYciaqsxOmvmGZc6rxKAfXe7tzawg17lEZ\\\\\\\\\\\\\\\/9HpcLTLdfWc3XEXGiKvioRG117dPMrqGqyH0mKiJFkQeFoBRbNT8YaNcXkW4JJXoIJMNelixWpTWZpo1XVmYG1fuNsdqv6U\\\\\\\\\\\\\\\/lZD0OnqWLxqp6325iSonb4ZXPLBITSv666Fvyu9wufK9xJdDwPul0yvMgtT9DkyRaRT1Yv+XJXlDbh2ppde8OaSAquU7U7JOe6xjNZW0iBgdIri+jT9wcYNAPQquCfG1l69rnskxcMsq6JrIAsd6jCLeryG3FsYK++ZVbANslJ1wLJV5nV03DBgxXIdy+Y8OE8mgjrsvPUOBqPSIhgREv2GI8TQuu+EWDGloFkiBMZ139+cLY4kkJcZ9ISk2EUewTz9alThpctYiQ2rOJSkJqyPFncnxM9ktLuqmrjS5Z1+ymZUAOT1MaatGoRtX1xL4ILXZVQpOOZmMR\\\\\\\\\\\\\\\/tUyVL4hmGqpFkWs2A4h\\\\\\\\\\\\\\\/L0Z+xefP38\\\\\\\\\\\\\\\/3vv\\\\\\\\\\\\\\\/CSq+9ytpSKXWkpayPuv51D5dAJMmHtYB0+F01ZZjn8H8dqTwSS8ohUclT+MOPTIZMQe7n1jLDWCILrptegkrpFq8CNHyyJm5dSlO9uieelY2Y30ZfSbh6AEz\\\\\\\\\\\\\\\/rh2kRSdtXbtn71HoOGbl0e3lVw5r52EgFyi+CoqP+K1YaDxPNDMRTAr+M4HKx1jDRmgbbsAVgegOoZ2MkOLn+0PzxW7PZ8n5Pv30Mql5Cm\\\\\\\\\\\\\\\/X0bsbdWojlRHO7LGeoRCWoND5A+5EuAoMmPW0de6wzCH\\\\\\\\\\\\\\\/69mSBkV0et2Yov08XZHcuEdWT3xtPrnWkG32yoO4XShYS6t\\\\\\\\\\\\\\\/zDvbffAL1AzeuXuldB4iauyJDV5UnKrJprGaHbEvDnpze1KqV4xjoE9fqQfVJoz\\\\\\\\\\\\\\\/cayR6vtION6gjI19oXwMl1jWXXE4KeJUorWkIy3mE+Inb0XblsK7CMsQnTKO9dy\\\\\\\\\\\\\\\/UYykiCbJbUR14uceyrj+moLfRBtJAMKbJB1\\\\\\\\\\\\\\\/Btx5AGzsMOlbaVqNWAygTVC1IDpQUwmQbkN0AvDf26pAgfb8BuLgJv8At7u2U6DmPOIIQ4rL9Pq9f3LTdhoyulUBwidb3Bu1vOn\\\\\\\\\\\\\\\/FAc+FesBqM\\\\\\\\\\\\\\\/k3L9krpIfwdW9K7eGnTeSqsUh1i6r0AwFo\\\\\\\\\\\\\\\/pzCdgg+30WCyF4ci1C1XrPLwqdKCmQYsQFxckBNo9LIkMqiTjIeIXOmT6jYavZmlDV04Awvpu68qcG7PbWPeKya74yQan7OZhcJavdEttH6Q03ZOYFyupbPaa+lIgveWJbFazeXYEjV7+2hOckvgmnXwr0wA0HDROvhkiedxyLt1eWz3ilY1icQF2cyGVSeEALcwnvz+HyU4WNm5aAb3mRBJY9TYRUTD4Dk\\\\\\\\\\\\\\\/WJSGZHA2atXs34RVuL822AIvLV\\\\\\\\\\\\\\\/9jiMTrQG3l9lxlVehPY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u002283DjL7hlaAfZjulhQ3LpUw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00228e39ff504eb72f15534896e5135bbc8d3ca4a60558dfec2d5b46c43871ba1c43\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/2\\\/e003731.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/2\\\/e003731.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003731\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003731\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003731\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}