{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022gJ7f6GzV0JHL5GGMeirbFYACt7w\\\\\\\\\\\\\\\/YW7eFzX53kV1zN48XFpj+fpo0v\\\\\\\\\\\\\\\/3J6XjxLrxX4gnFwXTHMNhGGHwxtTe7WJwuU5HNNVefTTrFX2V9fIsNdxg8IncmezLp4OL9wqbjjNI3VOSrjMa4pMetzeMPVj8qjVi59zH2tldLkr6gff\\\\\\\\\\\\\\\/gz9oXhJiSQpZ1ILj05v4Kbn5l+CklQNAxPeOT+1B9st1GDavOmLLriHBJVxfgbqlXCwWB7EAyI48lyvuGrkEkGyRSOp9PmWMXJ8u7OaFU+hDtEbA1o9P2Szcr4ur9oPXsvL0hMA8kjw81g55dVPn987ZD+IFOPsdIoT+cBCH75ezt8P0tlPSOOs00ZD7tx2tdHjWQOf8juOhDg+w1aavEDxdayj3BoTbZruBemMCwyX54fON6tJkfUvJavAr33fOafq44oxEgEabFIw0isMdlKjNNUssZGvrDyfdOXnwxYwgDSnYCVzHldxTWu0iEnm95TJ3T9BDXAmMaNMsjfeWpTZeDrFRQ54hdNhfRKsZcyugk0i9vXw72jG9IVkFiwHFe+fXeM49mT\\\\\\\\\\\\\\\/h3QAyVzK+sf3OWC6hZ6ARG026dR5lZNfziDWUKCf6o3NPmcvnzoAXd\\\\\\\\\\\\\\\/jnQjpcZM\\\\\\\\\\\\\\\/vRdgF294HCsumgoI1w1+0QhwRMLBmehXc0gnU47mMqFnpIimi6PxYc6dBbFHFzhWQYFN3frNVvBjKVG6DlwFc80bnhqHKAqJuDGfh9BgIRSQoRiJEgORobQYLfC1xWP+zG8YIDI\\\\\\\\\\\\\\\/ofkHy536tW+NjelkzqGgXAMQcDyO8TxKdW\\\\\\\\\\\\\\\/X2aIJ5q4eGixSyi7+Edm7FrhxkJIoCw6LKL7LcvdICsDJl6BFuxtB+DDhK41D5OYchz9VhuN5AdxK+T62fJindgj3nhwp+3MLUyU19V8bbaYiUi1T29pGsbKlOgG5ID7ajdufLTim4e12Ah7CcVfDZlq1v5eSPhNxeH7czdcry8t\\\\\\\\\\\\\\\/cBo39uCnP6LmRBXteAVWpRDiOt3eAxG5OP1SVTsaVp34HYp3hSlmlqaB2QMgqWFXKVhpPsa\\\\\\\\\\\\\\\/Sf1zy6r5Q6yk9S9QEMcZvZ6NpFCp76k+jvVy\\\\\\\\\\\\\\\/E3VCpbQXyPckmy1+E6qswFIY+J7kc7ARs284Suo8NZE88fpNKwXw8UcsZJlguJjduL0UiApsW3ciLYVhaKXMbu\\\\\\\\\\\\\\\/UBGwDSUH3BgvJ+Cmy6fX3WBXrLnOOGFDHggxHHOBgpGjM3MShdXppXb5C+dgmrno1DBHhV7HI5s4y1Rf\\\\\\\\\\\\\\\/sGCxN6W2o1OR4xvhtW7xG1URUlYepb5xeQPwTz5f6cgRpuOwhafLYunRN9l+AISqbbXhbV3XL42Ge2B\\\\\\\\\\\\\\\/dYHO+QYfUxECORv7JDy2ZPtZoz8gQJR8uJmTjNaCPIlJPpTZPO78d42uFKyzqiFqrCHlPMlmJ8s\\\\\\\\\\\\\\\/VXqJOMNkXMG2G4q2NWa\\\\\\\\\\\\\\\/+9hddcYK8nwwkGcOItFCgydZqcc6ithdmI684DvMLZ\\\\\\\\\\\\\\\/XrBgwahJzYED1PPHjvoYcYORuepumYQItR+Qt3c8\\\\\\\\\\\\\\\/E0hk5s94K5MDd39sE8SC2vYUGXiKDUEZgjOicFCfbYGtRL2eCREWJbVihyGv+08fUBIHEILU+iCCCpWkLMIkutOOrFIGQMXPbia+knKWVUBCcCONHaUuzsk8p4J6TBEDoqQ4jKewHIWieOax1SI5ODaUyPjzrHCnMAgv7Jdo9auu5+4QIjdStGCh5j\\\\\\\\\\\\\\\/pc8JHM7i+Adql+IYklqMMfpDH5\\\\\\\\\\\\\\\/KbsCqrAKfRajUlgAGfiVpa004CxtJm0E3ttRTpg30qxaD\\\\\\\\\\\\\\\/+msD2UlfI4s5+Ehd5hdsygbdPYEV19f7IS\\\\\\\\\\\\\\\/9ER+6BnI3wtNkQ70HiiBsoSMLkHiruNhooDCWI9VoCnZv\\\\\\\\\\\\\\\/0qsjqjBf10cxk3b9nqRbr6ZP9bzDsE2kE4TjZ51CIqq2z+kxlXxYm8xEbMYoZUo+TA4RMQ\\\\\\\\\\\\\\\/QKHQaFUm0oF4eM33MxLIClAQ7Wb3H3kSn+4oBGcmB6FMYI706XhTHx7Mzt8FvHh7DiVtmDc6c\\\\\\\\\\\\\\\/RL3U16CCYpNkCV0y1\\\\\\\\\\\\\\\/yRvgwiIdX7z20\\\\\\\\\\\\\\\/+TiRj7TtIM6jCx9Vq5YaFG6vrrCi10XtZuJgOVAFaCSm1WUAw+2B+BCs6LwYx4vbp0yf3g\\\\\\\\\\\\\\\/EKbXG7yjcvBI6eBTFXgWryH5x6x4lGLEoAaHXIgXHkg0X\\\\\\\\\\\\\\\/P1bNrUrMzYERLEv2HNSbbVNB2I0sHJq467iPpV4uf1ir8OXxLjvBZXmH6UarHCE9O8L3i1Lung0+laT+NXT\\\\\\\\\\\\\\\/vSoXuyUG74+Fss3+blqSHo2aTkpqkHQVI5mnsJfQSTOk67Y5WKfpnck6iXfjJPzz4iqPdSkk9TFODfsuxMlkGlMqauSU1I4pg6lo0zyRKNy3VbfpldLhfpMYDjstqUBZx99PeVpv\\\\\\\\\\\\\\\/Xr1tHV2HpaWosRWBa3H8CIdpSAr4Obd4+CWOd0qrLmirj6vohw\\\\\\\\\\\\\\\/rlg0NIIoo5ft6Tf1a3ZZSWv\\\\\\\\\\\\\\\/sJTf\\\\\\\\\\\\\\\/lhouHEkIUFNgmMeL4n44C7PP8ZAdnxF0VsOr0M7dxqPWgpGjOowqKHGkwPI2IeOe3d28tDBS7c0i3K95OKt8vn2N3IUMe9oCA7GJVOmVClt0uF3P9X9gdxj5Nl1Sn9ekb3hl9R9Z+Q56HIw6+XvyaMTqVMw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022z\\\\\\\\\\\\\\\/1TbLTWY40R3Xd\\\\\\\\\\\\\\\/2meDAw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00220a43c8b61081e78ff8ad9163aa31c3e856bdc78881fb93b1f0362cf0b77282f3\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e003131.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e003131.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003131\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003131\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003131\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}