{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022r8mNgoNGlq6pG\\\\\\\\\\\\\\\/H0C6JJdShwtTQ8kdh1AfQHyNxz1UToKRL+n6Uy58a4R5ksAOVrI0sJ0E60NH6qGGnZu8j11sZeXq5dC7lOpuZDDJa28t2E4UP8ZIXLhbjdHZVQbEFe6VicKYb7cumy7N9WBsmXfsNK\\\\\\\\\\\\\\\/A\\\\\\\\\\\\\\\/kGnOxEWmacnQfTa7Lg3Ii7M2fKkaAklXjqIn6odLXfLqks4\\\\\\\\\\\\\\\/PrAhw\\\\\\\\\\\\\\\/raWHjm0bAUkSfaNgoxBlmq\\\\\\\\\\\\\\\/0QtwsI27GZbXcoJmu\\\\\\\\\\\\\\\/fiXRssLKu\\\\\\\\\\\\\\\/ncZFQoRhGbDCj0MXM1UCB0oazr9hdCDHX\\\\\\\\\\\\\\\/aNRtCg09P0kPou86yiC0MwyxoeN7k9MpNpgMxQzaiASEq7ThQZCNVzlfHlVrmmlJMgyZRGVe3R6eVeI04mcWDaecyFa9uE1\\\\\\\\\\\\\\\/tFS5kFJnsIqMyAz4O4I0xlJ00K6YIoysGnvbiVgpvXS+Amvg4Yer7su6sAlyQ1W1b3tvqChFQROZKCZ03Vl7la\\\\\\\\\\\\\\\/TM5W5fcjCDNraDaVpwXChxCH6M9rd73jToIlcHEfH1wLG6SLySC7ZVn0wOn6XHFUI41wNFaEySWLjmk7Lcgwl0JDee8KrHiRhlgC38zhABS2DzTCQeWcEqP6WDg5aSgWlXITVTu+FjA23nW8eNxcnQT0teNeyYghINsbwnejKFWI1IuUQCESAqQZiwK74iebM4c4tMvfAxVVA1x4PoP8w4scZFaw8RILLiBM0IUJG5TmEXkfunOPzs\\\\\\\\\\\\\\\/ZeJPtVClnGLku2TJI6QRV3OmZ0WeOalws3apI6t55+MGv9YN0G5\\\\\\\\\\\\\\\/m8SZQMTYBVBwLhnZyP6O3uhHU4pRjN0HmVer0GI\\\\\\\\\\\\\\\/SCR0Gu9H43CNoPirWnwQn4f7ifQiIrqVut+H4aFcl4qWnvr2Zj0Q\\\\\\\\\\\\\\\/Ts4Qb4K92sXVf5u9z1sRJBEzn9oLE2gy5RG6Eofwyvl44szl7WODFvPsZHSHjYAF4oul7moq5RGEM8wqPaTJzMjxZoX3fkUnpRCHzneGIMqOteNSygMLaMBnpm6klD6dvMyVrCvszBcWiGUn4yhEfeCUj99Rfzd5aGkqzgyAfy7QKiTQH06FcRACx4eNDsSrQeu\\\\\\\\\\\\\\\/TB0UCX9mNvsIk6IKcv87Vx+rnU0p7i72p7\\\\\\\\\\\\\\\/b+VPh+gxHOQ52Fw41kKzgoxOFDd98jmAAHF3PT+Tum1hW6Nsd6oaI2IQvFqxo2p3E3nEY3EltFXlnO5nEbtaVBbme\\\\\\\\\\\\\\\/xNqQLRrB+VUAtWoZYKnkJM3uB3bfEpDGpmrbORMepZzNSlLLZnWUH7ObDpwt6rO+vp10fEimfNGK+PbNmsRO7a0Xsryuw2hZss2KUh3eAcSIURWjJfvSNzEM759imO+P+kb6IJ3NUWGIudmCE\\\\\\\\\\\\\\\/lVDljxg7o477xnY\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/WbOpqft6ncbeUlKzX+VJAPhL50mA3U5MQ5Jjkv6v4RyHLMsLKrO4aWO8VG3QGwz0bFScCoCjJ5JB+QZ02ePadivnX5URbpYpIQDP2E4+NhJ2QcHPut2ZHHBmTeejJBv75WDut5oV\\\\\\\\\\\\\\\/0777ICtFQnpjzOek7hULuwchNI9CYQTENbLP1VTUgusjC7dPliNg8tzMArA1p1sMKikkPbDdHNI8NdnBPW5NizvkpKQIDdGqC58kfIB6aUInG2FOt2p8TgfGyzlK+ZZzAJOp5nRvjSH3IlQiP1M3ibxXJOPof8G4gaTMUtBGwF+w2B5JA6eOkJ44WIZNnJ5qbMKz13F6IZryu2MM\\\\\\\\\\\\\\\/MSLknrL5P1KT+DRFC\\\\\\\\\\\\\\\/Fe\\\\\\\\\\\\\\\/4Ec6xwYX98kUbtUfOcWqNZG\\\\\\\\\\\\\\\/AutA3y6uRQ7rESBxLt6+g9NNbY\\\\\\\\\\\\\\\/0uGBzNhVZO52d3LOOAzNeNRCrfdMBdBMPAGnj8aoKEttdwg7bZlRYRWglAOCImKji3\\\\\\\\\\\\\\\/4SXiG6TcRYtZl23bAlJ6sJnRFN2S7eQKlK74U+\\\\\\\\\\\\\\\/7b7hVS2BLCsaIMJfYsHkea8sU6Zveh5uPtTzpXKodZ7x\\\\\\\\\\\\\\\/T6\\\\\\\\\\\\\\\/oWAfDRi9A6t\\\\\\\\\\\\\\\/Vt5znC3iqgKhrJxTcrlPktEfrpUeO5vo+Wc+nDBrzje7fsMRzHxouOcvVsYynjfGR\\\\\\\\\\\\\\\/k2RDq\\\\\\\\\\\\\\\/II6ckhSRd+8ClRVWWHsas\\\\\\\\\\\\\\\/GMTm1+m3ZZ5VRctWCXlhUPgLu4q7BO6fs9tLs7L3n9JVUNPP34fW8GTc3MfRKfjsZ3fpEP1xBLsDe4Uc+F81FphYwo91br4F\\\\\\\\\\\\\\\/oUvKAlYqrcWjd6\\\\\\\\\\\\\\\/cmeq9b1di6fBwUOkB9q8CviHXbFKP7x\\\\\\\\\\\\\\\/oG\\\\\\\\\\\\\\\/iJHSJFfUrR10yyIGVT+yVDYez3hD4xhL6HL4DIXdYWStcNZaVr6e91iNZT570O3YdvDApQuUzb4d+03+m9gwbjFRFnyRrrltsVACGcBgnaQ+0VzSuLMSmjS8ydResvdr933CnU5I2oAzLgP6etQ1xSu2w7ZCNPpimOKqLoPyh\\\\\\\\\\\\\\\/6wNuO3pVdKAwueEtv\\\\\\\\\\\\\\\/USALYUnwoD9Fb7KSTX0YV8KAGTaRGASRCSNxucEyyXDsFS9Ccxjuue4cF+Xh6NKWLGS8rvL7\\\\\\\\\\\\\\\/YzpXpVyOrd+vKbHydnLl\\\\\\\\\\\\\\\/4XG0G1eqv7KBwfX2trxh6oTlMcT3jVueFWJnK0Yt50nIV\\\\\\\\\\\\\\\/mKSmWS1AZH5KFU1zXmI7yL3KJonJjYgklCNPtAhtP0+yrLW70oGPb24Wd\\\\\\\\\\\\\\\/dJ4cvlZ\\\\\\\\\\\\\\\/XKZAt3cB7ew4esE9G0zXoiS8oExN0R8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022QdrxFLT1Pp6a0EdXYV3wRg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225a99e9f7754a60c87ab29db4924167fa65ce952acaf9cb91dad9a121666e5098\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e003488.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e003488.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003488\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003488\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003488\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}