{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022cqWBdqlBeL9L+sWbqTVg76nAuHjIGMsUVjti6B6OdPA0K8cGWeHDpcNDjp3NcD7ryN9wpjVjKSXx7NqbuDCCS1JW\\\\\\\\\\\\\\\/UochvyrwBkUhzdnkVsC9meHCnEr\\\\\\\\\\\\\\\/nqg8Y8yB9dbdJqgncaBTv7m0kPKIVJsaGRAJp8Y9Lrs88UgBKQDTK03tXO5tRavAfNMECjAqKYyakz9GcXAIyh3Lx8ez3XynGPq9R\\\\\\\\\\\\\\\/pqTT4f\\\\\\\\\\\\\\\/Bb29TlNXmkiQyElJrUGmBo7vQgZIo+\\\\\\\\\\\\\\\/TujmM+9SAfOu8i\\\\\\\\\\\\\\\/C2A+ZcyPAItlzFIxlteTTalX2Z6lN5nGABwzCLL6cX98b7SAC\\\\\\\\\\\\\\\/VmS7AMig7tvnxnFWAMTqIrpX+mJb0RPpIke2Ev3lJJX4Wz7l3R1n9eJ17jt9pIkQYkNjXwKZW2t3VQ7Rgc6rAqEwQkGufPkK2y21Brm+F7rL7+3qCHimPaelDaQZSqwzhM3pQCyYZtkupTnb5B76Ge8Mv6i00839rrAXd\\\\\\\\\\\\\\\/K4MVDTWObGRcUm4YDhpNgxg1cw\\\\\\\\\\\\\\\/tE8kf+ZcPWvqLvFF1zOdRKc7sQguVYK5zvVTYUHvNzIOaEviBabkz4aU9feGeeT1X40Aq4puyLvETTPyyPqHPcyUVHujkvgqALN\\\\\\\\\\\\\\\/3y9Td52rgY8pbu4bife0111tcCdHcE9bnJKEVb6Cf918+3rwBKVh7YPMssNLuZD5iNx19vDpxT\\\\\\\\\\\\\\\/BJgeepf9sC3YEiJrAJDM6C\\\\\\\\\\\\\\\/j77Hgt+AR732CuwVXYgfQIo+6scuJ1pTuSil68V0y3LaQwrRyjixJFLnD2RGYnpQG1BSZ8lUrzYRNIrM+jOZEFsv42q6U+U3lpss++dDsbSvlNaI6X3tyIgoA0O77i9hLMV0QvNJq+CYKyAZqyi5QMM06S9qDIZmrjdAdhgy35arXEKmY5YwIMskuDj0PBktgDv\\\\\\\\\\\\\\\/ekERpeMz3XR6VDQpaMJXcief1ufp9jgBuhoMoqCyLxEpHfDvirD4i4pS+0\\\\\\\\\\\\\\\/qCd+qFFSk9i7i5J6Q72hn4DOZX0AvLJ+AZTuOYC2EMe64+yYncHyzp3FM8W6jSLSDCffcjqrWoPwz10YKOhAOXZrnMNPMZcVrX9KYlXDrSthzlwTbVZFLpO13i4\\\\\\\\\\\\\\\/vg4c8M3RQr7fqrxj030WlDqwr0njhf1KzGhPJOqUR\\\\\\\\\\\\\\\/uvYmJAzUBGm\\\\\\\\\\\\\\\/sYgd72EfFodxY3CzyVOug8VHrLi7nLppkXPjDWSA23U3gqK5eFmLy2Zkm6RvLzCoxcsB4g+77lpXhYFSIRzX2GJZMvA3nYkUhAy5OIJzgapg+34pm7pmIhLndVMOvLaB16gEYvZGoLoNQPFFVG5F+i+BXAhHCLlcGnBgXMStNhHhyBdHJVziwyXRfUbOGGkq\\\\\\\\\\\\\\\/thRd7qadg6a6fMrjKkny8FRW6n+X9eRa18XHpW4D0kgOkKMgUkb0U+1NPWE0fQNZRI3GptnC8iKAB6IGi9JKSwbZcFN\\\\\\\\\\\\\\\/gbNJxStMw6SAt07z\\\\\\\\\\\\\\\/LD8vPRCeKiN9SSik+dkP1XSDl\\\\\\\\\\\\\\\/Xw4X7yILDOQm+DbJB8bg1jDCHNEBLd6Lh2Z9g\\\\\\\\\\\\\\\/KccQKIn17ObAj\\\\\\\\\\\\\\\/pyynm\\\\\\\\\\\\\\\/K7QDsIT2ZAjxTLN1dXMuiKkCxrdZ8jgr7BBbgXAAu8GsFhHRZwOH2KAZKS93\\\\\\\\\\\\\\\/LFsV\\\\\\\\\\\\\\\/B2VQAp+hsVihOTOWsomcMeM2YBzTzJZ04ijfijrnuE9G++3mQ5sGxtUDI9AXtn41v3v6DUqKNYaLK61vRRBCYl2NgpEdtZ9AF\\\\\\\\\\\\\\\/za7lA8mZ49PdEy7sRVRBlB3sbWutLMe9UejYpru+0tBmCwY7c33zo2utJ5TkCc26zaTx+yR7Pp3ICNi8gfRHJRKhpRyczGy9HXCE+1g6jZ5O8akgX1uSnKDNjiFmmeIy7lziM6BGHWMQLvL2BZEsiyDOiH2IE2OTceOVks\\\\\\\\\\\\\\\/7o2SUXSPa2ychIhCEzaopyxcNJUMHSawc2tsl1plde3gHgOWmL2UM4KWuIBoQtdVF0i+LZIcWqFvopLG\\\\\\\\\\\\\\\/xZmOSxkspIJQG2yKXxzv0pf+UtX1X+DEByTCNtZ4jktjlBgzwr0LYuVnUkw8\\\\\\\\\\\\\\\/a9F2HzIFXZttNM6PuNq9RwqW7\\\\\\\\\\\\\\\/GM6uQflEXh2cbJDTzPT\\\\\\\\\\\\\\\/ihAIjUBCtpycN1eJGT2auI8uvL4jW+5cbeGhvBSsCCvd+ozjBcKWRhGkgd71qBeQIXU3kjB3gy\\\\\\\\\\\\\\\/nFAw30CHEJbVbg8DkdWZ1pISk4oM6\\\\\\\\\\\\\\\/fI\\\\\\\\\\\\\\\/pwksVXgMispQ0lzyZRbvzsdBAucSvKFaDXCdQ3QAut8pIHLWnx\\\\\\\\\\\\\\\/X5n4cjPKJF9i+5guRL6cZm8d\\\\\\\\\\\\\\\/Q5s3KGGD4s9Oi99czDpwx5EY0Wyrh8yvm+uqorXRfp6uYb2pkymS5efjLpKCrasyudRwrPH9jb6U5GJUEFxceeCVnBzwQyB7QIqcQQPTu0J1MsIH21WHfioi9Miwc1ZUt1umqFDaXBg7MltW3TP34R5b3LDRp6QD93j\\\\\\\\\\\\\\\/WAT6YQPfAjIwNnOForctogNlDrI5I2gSqhxhURbPjP5looMNF4tmq6ziwjEL8gF8qLYcF4Y7sIdrw07ztq\\\\\\\\\\\\\\\/b+JZnWQ8oY+pck6IwdEKXNWme7Vnk8e9iMH6IsEpVWwLrc47CEsyhIWkvy3wp28V\\\\\\\\\\\\\\\/+TfILMeZAkr72AmviO1B6YulhnX\\\\\\\\\\\\\\\/fb\\\\\\\\\\\\\\\/Xo4lgx+zR\\\\\\\\\\\\\\\/u7dd2wG48DZCTC8=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022+B3KZhfDE1xVg5nzwQw2zw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022041e18f5a79b11e72b3c40cdd278e52f66e0553217a26aab08c9b73bb6b25d46\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e004034.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e004034.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-004034\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-004034\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-004034\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}