{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022T9roPZbvzqO8STwbTNJDF60\\\\\\\\\\\\\\\/RcL0zcRDdtkRyCCFdhfqCG4lTT4fBNSiUE5onX35+s9ZehiU9kqM8G5wGSlu9RsvXAfRiDWDllGcfTWfUjaQjsgY1i9Tkhc4hE2SCXh9NrU4f9yHRnmeCkhC4HN7l+UBFrBV3gRQcv2hzbGm5uQHZySaHnO9sd9AykwIw+64sf6EEakxdHguVoIvrTHArEAtQa3vk3CrYsJfX\\\\\\\\\\\\\\\/yArveEo\\\\\\\\\\\\\\\/tqM5xxVg9DZVNbprw1Wb2ro2UuT6U7ZamotJEK7fKhrCGhJ2jv+4Dx0olM6LRgWx6rpdtkswkYCdmElvDZJT2PrlZin0F8eIhf1Si2fmli+\\\\\\\\\\\\\\\/QLUtYmhB0udlGv\\\\\\\\\\\\\\\/wQ3Hivl5nN9xeBoRySUScd+Zg7n9g56UzEf3vkzdQW8YdL8sBizYOXgpX9xm7ZT8E4yPFNy\\\\\\\\\\\\\\\/p1rxHtn\\\\\\\\\\\\\\\/QVltBNg173H7CzygVPx+Bd3zTOBxnt8QPiDcJzY9n\\\\\\\\\\\\\\\/yh5WNnWKu84GJBvCug\\\\\\\\\\\\\\\/cfPwW6ugibT9n3u9RqTTaLKF7cIJgroYuGB0Y3Ba7yVMg+ZuRW7EPuSEaY0tOJkGl37F6Th8cb1hODSezENaLNq\\\\\\\\\\\\\\\/u+tp4i\\\\\\\\\\\\\\\/uykWyqsXg5s\\\\\\\\\\\\\\\/JJHp2HLDuqe3St5EJe6lkgQowpf2T1T+gCRfid+xkWGkejCSKHSA8zwPQDFE7Ivb5q55PAkvoCrm9ns\\\\\\\\\\\\\\\/VzVg3iXdDISxYNmaxL5WvimQnuYaug1gvtgiqwhrooSPN8ksFJOx0g9CDLeBgueRY43FL9D0rVm8\\\\\\\\\\\\\\\/6voz1Ice3gW6saBzrPGlzSKYaNvwQ2U5kfRuMHCjFFCFgvA6ZFdsDV9c8fqrRNkRqaeSzmZpWRWvDlbY7OHn920Z0H42MKHk4vNzz50T+KO7dcqxbevjns7Nbfvg152YlToj4Bv2kpaQPjvo14NIPVpXnG2SCOT9sYQePFC1Kt\\\\\\\\\\\\\\\/oK6qLcx+ax7ssXs1pF543Rfwds+Z7RbvcK3LZa+WdR1ImrJiudtGuiRqMcH1xWKNEut\\\\\\\\\\\\\\\/pfLSIrmEGkzHBrMoOHVtO\\\\\\\\\\\\\\\/xyeROnKyN3qjbtgDxAW1irPuLM0USSGlZ3zPUn7D\\\\\\\\\\\\\\\/NfG+IGs1y1EA\\\\\\\\\\\\\\\/CIeSg4B1ZNj6+rYV6bYHwlW1AV07XM6I+Vw5u3ueZVU5kukeHtK5GKvIDEpCUmFfb5l0X2eogiUxjsh6i3UPUsxjEkU4XdhE6oUZFeKBCJmrALvO6Wdz1hZddfCTEMh+P3LRGircc9oLbGXdyQWqxXRIXltcmE3aZGwWvglY+4EI4e6fWSfq3\\\\\\\\\\\\\\\/ZqnOU6RAeQ9uZSBOTA3ZsURHZI5uyeG2Khu5FGEgBKHkQRfTawzDN+mhVvtOLis24FIoPJQMDR90SVOx1VoK1J39SkFcvdYG6cLbL5KmCFwZi6D7S+W9XiF5iB9zl9RZpPDO4TPNmVXnCapr4v1toBHJLhkA40noYqa4LUsAJMuY3pLn6mPFJU8q6TGyc8PU\\\\\\\\\\\\\\\/RjHxFac63\\\\\\\\\\\\\\\/H26YO85N9cgb3OQb9P+v4D3vdToaTpkvmw5WEsiPeWPnwaS7AhaBu\\\\\\\\\\\\\\\/nXZ+nFV\\\\\\\\\\\\\\\/U1kFkpl5ULsacUBPOWG9GmvDODirhQqaF2gxDDfd5QULn8T1bJ3ep2ZcIuzNqA\\\\\\\\\\\\\\\/6M3UI3qrXTSi8ML4HI6i8PB7XzITvgZoTbshVgWJGpy3GezUa\\\\\\\\\\\\\\\/HN48iwARKXMQ6p4KzEGNKcX9SKR9YSMubXDrnj\\\\\\\\\\\\\\\/g9HxkX+EoHcJwng3Mo4I4mYiuw1SyWwcYwgpiXpuKLudtCVDfjLhTRrDO65Xe2VzMBO3ttomcgN04VhfHdRvC9igVO7Zmf1rjPeEzqMkuS63cM1DbEm3Him9AM7VhUCMSAmEKlZA+CTs5hoLZyglFbYhFuc+uOdd9\\\\\\\\\\\\\\\/uuQoRv6zsh2hD47+eNY\\\\\\\\\\\\\\\/ay00YYBM1AX\\\\\\\\\\\\\\\/+WAyeB+Pbp39iT+JXBGJiLTrOmM8gsOCUV0nBK\\\\\\\\\\\\\\\/ojFoL8YPXmZdv1uUDCCk\\\\\\\\\\\\\\\/ORvNjQ6mR5xHOqzhHUTiNH+8fORgeEpEoiubYEukyQ\\\\\\\\\\\\\\\/TBVaTkjYDeUe9IZ4QYhTXmScELvymC8wUkDjvdYx8vCz1eiuOpM53CcZdfLKA9V775uOOoenphoPLI8EpzvmJ4+kpa2aLEWuH7zo5R9uQ5c39WKV+HuhLM0gwG\\\\\\\\\\\\\\\/0aigL72FSVTImHEixBoqMCYUIyMRSzXtny8bWsyP9RNJgDsLpSqdUKiAg4mMWKNI75bVN9ZRRucdMUb1ZYIaj7w776t7t3oqWn1Hbv2\\\\\\\\\\\\\\\/6ncOaflXF9z4hWQ\\\\\\\\\\\\\\\/w\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/fz0ZvQJeIYd+nUUPQVGku8OnBvR\\\\\\\\\\\\\\\/fCcC4rVWVFwXHoon\\\\\\\\\\\\\\\/Uh0XkfEnATIN+fkoCaj8Sb55Q5\\\\\\\\\\\\\\\/1ncVF+LYo+cex1nCTy6xAzUa9r3Fi\\\\\\\\\\\\\\\/q6GvjWFqsUUc+Fj0kCVcgshbZbKgd2dX7ffWNJQYmYP9Iqn8vqBFXtBEk8kpIQX5TmLNO2o7h68te9xYY\\\\\\\\\\\\\\\/sraNBFum7Oi4mxgoVmMEkNIKXiYZpL4O0yfRUq7YIOQmd0rVxjDbXi0Bq9Gx9uGAC9M\\\\\\\\\\\\\\\/rTG4yMetkEHRkbFKGfjxZY0y6O8PzVBX79dR0ReVx18Icn12dSkj3lfGj+GhDkerjczrEF36SUVXgayR5yl9jEM+eHZbaQ77faM5CqPQtTL+4yW9cci2iVLwBFynE3sY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022psoD9JOWdc+Xay45MGEdEg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022bb2131d2c216359ddf0a1609294ba81659b62922e6d910ea4a46d577fe38505c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e003779.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e003779.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003779\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003779\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003779\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}