{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022URUykABEgRfAIahIAG6zYDGh9pQAlm3d1cDaDdGwyjlLDHAANg9qaUhMBjfwsldfY9Ga5AQszXVGiXhzzq6Ddb9RXEj6zvsSYpbMTRXG\\\\\\\\\\\\\\\/3a5JEIgH8E97oj7NKLzjYL\\\\\\\\\\\\\\\/enJioyxBO6LSuwT1bkwefbJtP++zqdKP+7pspPUQeesruch4TOsCpcRgdq4EfTs9V3qU8\\\\\\\\\\\\\\\/9jsMDFvCuZspUN4wsp4lNwzTgM9DIF7vg+kuy9nAI8dQwkT\\\\\\\\\\\\\\\/+kfTvd\\\\\\\\\\\\\\\/rei5ywN5Mw4aEBcX0gro+8KtF6jE2d7VY851pzRDeGZj9s9kUbN35YJ2hCj2c2sHwVDZy4F+W6xtimxLCjOqOa7v8B0JWj8izRVeoXY+jjdzcLpjhYztfPbLBOr5HasO3DpgAb16BuCEnQZOAqegnFt6j1XlcscvGf79F3elZgw2YEvzogO+i6jOQ0e5sp8cYRhH4YSbfsaQ7HD+x1VZ+whGe2iPP0bAsAILdo8KQsgtO\\\\\\\\\\\\\\\/LfTgfAebEjOH0sGNHIKltMmXAvp8S8BcS52koXQVowLF+9aFkOfzwCL12c4roKxfgcwp2jnJ8jPkhfwYoQCh+ENYG\\\\\\\\\\\\\\\/Uxi\\\\\\\\\\\\\\\/1v+f+z8LFcxAkgl\\\\\\\\\\\\\\\/2fFwB5Lf1mCXlKuqUCb0pZuERgWXd3XmIbO9sfxM4TJaQYLhX54Atduze1VOxDm6IsWuJ32dcFMBfkM71tlMm6ztR9dyL4XDnbjWehykL5PVTaUjh1HM6uYAeWKuDjSRZojDDu1XjBGE52RHKGlQzEznDNL3OULIkKqBaGdCdg4DO+pKOXxZRO\\\\\\\\\\\\\\\/OGovDE8tyZk1gv3Pn9YkjcRteIgMMJroLu7QpXNZS7Z9xMYBBtbup481wSnfDnYUi+U\\\\\\\\\\\\\\\/n8zzlTUVZmi2StLEv79ML8mbfQ7OlJBxQppoQiWHEXaeu+ruvePT3LcoBzlQvM3s1hPXQP8UavmpGn7mKSQcsfykgVilUupgEmHfW2cBkavsWQRCNO7aWcNyyEwjLU37vCQS68XFzVWTVUy8MMimHKZSof+5YJarSkqi2tkr2PqBY0No+09RfKuX\\\\\\\\\\\\\\\/d4InCangrg789iTlX+MJenkjVg\\\\\\\\\\\\\\\/TwLQenhlAyBnx8XvG4pkxDS13nX\\\\\\\\\\\\\\\/H8gSdoEd1K63bTcdicUcVpye2+jkjzOFNLedfeodtDVVNPFGswi0MSrGWt0gKklD8k3i2MXQ3lUiM4vTGpP8ohPj1evazxGJEbEg8vBX6Rv9923EfnPc7dxToNiF03tuikZHtsl1HsEZUG9ethPRnauhEHGe6vjf6WZhbbRUNgmAHhikcs0b\\\\\\\\\\\\\\\/XNwugzeOmPdmcDleB5k8ss1JWUwHyeNf7EC71v1kJS41YHiHZF\\\\\\\\\\\\\\\/dnJEZLKkxtKO0yPzv7w3TNFEEnxJaa5mrUsR1cD4pmejgWMgmk4We78NMhQxfb+nszRrhiycDKMvk+hFQ\\\\\\\\\\\\\\\/cnIukLbPuFkSJqVoK3M81Vyxs82BfiKFuaWjXjQbp\\\\\\\\\\\\\\\/qTyOFKCMr69OYjZq0KgPD9sIwi\\\\\\\\\\\\\\\/vNupqqp\\\\\\\\\\\\\\\/qTafnqtGVetKr2vsYeMo7\\\\\\\\\\\\\\\/vAoxurdptwevWqogSC9am+eMxxQj6UAhRI1w8eGbWxBr6hyjfA0E00bwf6aZfbOikoHgN0US9b\\\\\\\\\\\\\\\/6DyNxvasDjqHS62cA8C1HkMW9X5ZCmuKaSsg54+L2tsvwc62PtuKtT5uTeipmJjuD7r062ZED5xjQmqS\\\\\\\\\\\\\\\/VR9+Rs+mQcf4vRLN59mz\\\\\\\\\\\\\\\/5SCfxxJwSka1eIbe\\\\\\\\\\\\\\\/Vkzd7vtL\\\\\\\\\\\\\\\/OUMX8bxBWCDZK8a7zlPwm8iMhtgKkAwXtcGOcjEQMI8ijRjGOtpDgi6NPSEPuN6hR+Y5ImdJzHpM2dOPMya\\\\\\\\\\\\\\\/+O8\\\\\\\\\\\\\\\/Kfy4oPI7OpKreQM5nZhQaJj8KWkTGpNB7RyGiHVCcYTH3LnACXJMTAJOSk6Nyu+MJfhQAYZTHTQlIpodYPzbW3zsXjkZplNDYa4Vem\\\\\\\\\\\\\\\/cV9j+7MMwoq367ivfkP0VzcgVZTZHe0qB+XGX3nwIasOC8aEpAhV3A\\\\\\\\\\\\\\\/nGAFGDsLsvrqrvxqrYZaVra11eQYI4I52DV+FYfYV7kvgM3Ws0WWP\\\\\\\\\\\\\\\/zb9Gm09QrymwByso89D5mheEevvInbIk0CPuDmd6zS\\\\\\\\\\\\\\\/SR0kZaqGBVhLBoyj9MSQELXcPaj\\\\\\\\\\\\\\\/KPheA0HXzSMLWbRsBoDeT+6WudKenPElso0KROP9mTGT7cAafWnHYEa0KSxLfvijmonaNBxk6yjMSlHzpp\\\\\\\\\\\\\\\/fd4GVTqucafn5cyU+maIyXgRQk8kFJBYHUw9FsVlGCOxonhNLkjPFvQ6d8mDBxPXbhzNoOxUO\\\\\\\\\\\\\\\/1coCCOFKu2fvlBSLKIkiNDyc0HRfCQIJUQy3U4vqTo0hGiLjbbPe5RPSFi1pPZGx4nB1QD9lFSilR7YbBLao4zeTfiVUUiS4j6wftBRX9KU0314N5xSoBKrCHWCERU4ce+hJAbG0xk1+ElyXn9sOoXzyl3rbqYEbZUMaPJnXe2HUWx81fX5aOc17y3BQI4qG+guHpGzunrKlpJALwxuVWdV2\\\\\\\\\\\\\\\/lRVsbtwMnx85OSntCd5zEAFcTnwpAGi\\\\\\\\\\\\\\\/CVwZMXo5HXUiUoq+F3+g+GVakpoVJYeJmFsY1DfY8svw+S089ismrmENtH0AFzBjDgChgaylIxLi2tZoA6tGrL5Obol4bLNWfIDAaAG2eetQHRlko4RnnI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022WU06dQIGpGe8S7XV\\\\\\\\\\\\\\\/lDp6g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a63872b720e5c8b260701d9ee256dbc1597f0a15f47d4e31a37195bd962483a0\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e003078.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e003078.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003078\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003078\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003078\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}