{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/7e1NnORFRZ73yZugp+xvM+7yNMW5YVHITnAXXPC9PBGbKI6Ma7ZtaT65Bjui6zghtuGNvEJjCkNUnHKaWG75hNBQ1L7WmgazS3fWBBw\\\\\\\\\\\\\\\/ewrCWoG3ii3uOHVV32lJNSU+Ai4Ul9hC0ObZHcio96mfCjU5YL5SaIVx+xYNfzarfk4HC7NXrJZECoHRaqNVn2p8+T4Gmw6AAm1watGHeFao1lT4IAl8nWXMTCf7HYjO3b3\\\\\\\\\\\\\\\/+38BeIMvbDv\\\\\\\\\\\\\\\/6hyhHB361s50xx6ygJbqycul7MSl1VUp+vvLJedNau9KswVJw0HAkfio2SnS4N+X2LTEfKKHPnv\\\\\\\\\\\\\\\/9m7D3vhivd8QwCqkhzT78KErWHJItWDQLRW5KF7HcJ3xIyrOfNF3jyVyhFEV5W558koi3gl6Zut45FtE1xxMYeQyYh6u9x9kORcHBUbBIT1yMk+JDSFzjOfLy0fUYYNdZPWjHvTQqPXMglXRWALpVtv6zPWKRHyIgYcBWK9UP7vx91gpLOT+9CPvTDbvpgw59kjzS9KXNfUfe9qi8c2GEpbe4umGx8QfgvEBzj+INQ9e46e3kTMgHup\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/Udo4\\\\\\\\\\\\\\\/hb2j61od9GDppVDwNCSc0IO+LGtLSp9vwdf\\\\\\\\\\\\\\\/tvgSt\\\\\\\\\\\\\\\/JI0mN1TXQJNP52EQC84UeakxPfdG79VNuGy60+qM859411a46SRji4qNmQ2emuMh9tvXUqWtwfXayZNKRUu1ep6RNKrAvvv2tMuyhp\\\\\\\\\\\\\\\/dYeYCw25eMFdiahRSnPJRriO1pHOQvBaxqocOe5JimMvQlg3VVKdEkqkF2lW2o42jNJbMu0yJphtrefF\\\\\\\\\\\\\\\/wRoCb48azntMFVb3TEJNZIVXkg8TULBhxEdxJHKC2Y7uF3d0aefTVYJft5PG4W3HcYJF3AMDb8pNQ7zYHOAS1bSVqq0fuO0pOnf9eMQgwUFeQ5Leit8yaxxfhPmcpZ0ssEBNDu8woWyDEg+MeywNOPamqkIElfNbAY1Fa2xj0te9DXATkfnQdorIpASQUuM5Pr27kg\\\\\\\\\\\\\\\/fdHaI1RsSEbHDXFfaDrEou1FED9naFwpMOqJpCEx2y6xrKs6waJXHfUC27ktcZnDk98sGBCc7rhA6X\\\\\\\\\\\\\\\/PGVxXV8LwsL6AfJL\\\\\\\\\\\\\\\/65nku+7yOjVu9uilNHzkfJmakeLiKpH7hBJURUp0WbFWd4Sw7ylAxNjAsFHa\\\\\\\\\\\\\\\/tS0UZ+bR3OynKIvXgkqzAKX61\\\\\\\\\\\\\\\/L+MrIJxxrcSDdFZqu1XMNcZumItkNwvec6q1mUF\\\\\\\\\\\\\\\/qp5yYaelzQ5OsvnIcim\\\\\\\\\\\\\\\/dKsPjg8ZQWhtCaeFmqzcjinZYCxUvjkOqd8\\\\\\\\\\\\\\\/tg8hVHa1T0LDC+kTrhJElKTKfjoU2gSQBY6gXmGMyO7uFSDI6k3VWYheLLLWVU8X9vBagJKbjcYJRSXk2LqKDzCC\\\\\\\\\\\\\\\/nxOPThquXiLrOimtw2vddYnecS9qW\\\\\\\\\\\\\\\/L53LtrObzDzWk4Z7SyVUqUkdhL5KeRk1rYgdtZQeZjbOCdH6wJfWGqxpDp5ZQL0lvD78X1xCnkJK5iP2T3GddfruM5lRkCSqVo3HKZXK+yyBzqxFpHYpNTV1XkCCVdGazx7aC0wG2UjAS5zMLfJ8KSKwkTPuD4bZrFXuKCXiDi57nZ4cJ1KRiI6Twbr+EFXw8u7lFrA6xoMHlcbFgKTMdS1vlxUXQ7a79LGNaaP7hzncjum\\\\\\\\\\\\\\\/Beh5UUlJ2I7S+EKi9hjnKyw9JHjqqIiooLHy6ag6WxxFAKDkKsh6+UspGGYkkB6ANS8B3kjz91N6f5jg6RhMcHSTaWZhj9uiFcL7kUuvev0crDPKLqnnDkiRb0\\\\\\\\\\\\\\\/vFngcq0vMaoJcuz6Nilv32aaaM5w71asEsY+m+yRC0lf3IvYYWPNYxs+nyCbbIAOj8MleS3oQPFZM8OlbTr02EbKKZq+G\\\\\\\\\\\\\\\/SsyW+\\\\\\\\\\\\\\\/RpeD2JfsCEg1HSRPLVYYRJJNheD2O\\\\\\\\\\\\\\\/f6eQeYlbQa+5pgeSAyj23nAHACDqe\\\\\\\\\\\\\\\/SsIU9\\\\\\\\\\\\\\\/O5oDXo68z7AvZL7cKN2SWddrkTm1\\\\\\\\\\\\\\\/tmkH2grOn5xH2D9eelEAffnnMkMfaJoCnZ8a6elYA9NwF85+Iyu33QgR1G+1FOdKJ93LtpY+FRu8SmW7cVluq38S1H\\\\\\\\\\\\\\\/i3c+Wgb03c42YPyKo7la\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/a+8qIOMvFnS7Y4ZCR\\\\\\\\\\\\\\\/aLuc\\\\\\\\\\\\\\\/cl0WhPAy92fIjWaOb9Aawk\\\\\\\\\\\\\\\/mNQnmhP01S8cnYp7tSDeuFvToYxZZzo40uwWpD1REQQyIrc66UGPMdUIpD8HXe9dtYTHJvWdpw1mwx0vn3D8a4SutV64wvRI+7nZ3C4R8TDmwUSAw1C8HUVbH2c6TAaG66\\\\\\\\\\\\\\\/Oc4A\\\\\\\\\\\\\\\/Cit1R2Hn+LpyjKBKLY1J4aazUCNhn3y4xoSXr+EZFeyfJt3BhU66jfrPsFaeJUE7yR1UyKbkn5eT9VVvuMmwhtHlcY3Aq4CnRaESiss0F0WIPcdOqD8s+ON2lCwz\\\\\\\\\\\\\\\/N3Xp\\\\\\\\\\\\\\\/oGkV+wBW\\\\\\\\\\\\\\\/QrZnwTcdd5RxU0n0+dxdMVsrhLSZQvZGTg0aei91yIhNBGa9VtHRVGH+dzS8yxcZ5rmBDm6Ml5G2l5gt1mV5x6bFtPD1selRn8kUX\\\\\\\\\\\\\\\/UO3KRe8EuRqwM6KjF+EL6PixE+s3Fpng3GP20Yvry0H+pbJEuCAkQtO+k9nyyo837uJArMfIE6eHEDGqjzDZd8mzowAr8RyxBgQn3lHcmFA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022\\\\\\\\\\\\\\\/tTKtwyHg8nayJHfCLXkSg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fc305c4a1a73868d7ef534e0b9d383bc66fa8aa49ace3c7233c9ffac1d80d7bb\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/10\\\/1\\\/e003069.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/10\\\/1\\\/e003069.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003069\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003069\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003069\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}