{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Eb\\\\\\\\\\\\\\\/0QqZtfnVbzyeIj6A9CdIgaEhDtd0pIkXxAmCemINzmrRzwdFF3Dvn5MBaADTqCvzxabHuZ98CeGUdWMbX\\\\\\\\\\\\\\\/wdpxzBaULwJo3EzxuUIBhUle5JuHs0ekWmCLWy\\\\\\\\\\\\\\\/tfO+RfWkgNZTsmcpHpxPqDbQpyt55x52umTXEIiGt35diVG\\\\\\\\\\\\\\\/W3iDruyc+hGHE6R1cYpE6a8HyjQhX7HpL0QohZa5H9L\\\\\\\\\\\\\\\/xtELREGKI1cdt5k5zZhHqqFFA2eGIUw0FrDEjsv+U\\\\\\\\\\\\\\\/skMbFwx\\\\\\\\\\\\\\\/7mJYtVZVTLlFaLg7vSwI15\\\\\\\\\\\\\\\/Z37azQr1UkFKQg\\\\\\\\\\\\\\\/ibXcoyzOwAL3rQPWOprxBbIybW0EuzwdKFGOQK5h\\\\\\\\\\\\\\\/KbZKQC9jQVECpGP0Zy5Zlkodvsj8v\\\\\\\\\\\\\\\/La\\\\\\\\\\\\\\\/G8+o\\\\\\\\\\\\\\\/HPfUihYY8zLqM4hr\\\\\\\\\\\\\\\/93DkUvHaOchLSqpfWQxRVddrv9BLNw4zzrDfB1Vxpn+r+AOeQBV0SzcLHo43X+w8\\\\\\\\\\\\\\\/i7HbOwLQRIYcWC9WPgUVJVshYhYF0nXUHO2NCCD0KxYqsTCjbuo54W6UrEwV7VJ+6h0eUdJJ7SC4RZNVDuRinfhmIFkbE1sBp\\\\\\\\\\\\\\\/g+u4RiRWj0sYF3AYH26zawCrbcYX5AmAosihxqqEBqdbhvCfb+jGDqGHHpz6pw7sRJb00vJGqj\\\\\\\\\\\\\\\/UZuY5sUOC3RfC5+Zny9+bnb2f3IC9ZcqxVl6+Twk7Xw7NL6yBa3+4YWze\\\\\\\\\\\\\\\/KtMsE3t0V3rxoANSQjWw8UcHUfaPnPjko7PU\\\\\\\\\\\\\\\/9oTMyCn9sOOC8KSPa3ZjG6qeoCQZOqTa4cuLyHvI3i2Jz9LNSwqlC1no2WRTJ+zrGDyr9sLAJgU8qy2KlGprRhbXhA81Fj\\\\\\\\\\\\\\\/nY7vJGz\\\\\\\\\\\\\\\/dQx4fbaWjbE3A8YLaRjFGe+GvoJG9iK5+BeZTMGGt2DF3FxVb57jnar1XfYyUtB9m3b4Ls6QjCWv5ny\\\\\\\\\\\\\\\/lYk6\\\\\\\\\\\\\\\/QRVE8WDHUPqtvZcJp1bEuxyX9jA3nPMH4Dn74Pj9BpQUeDxUJLgnRIoDy3s03mVD3vvS2FYOxRMb2l3X1jWJx0ba3B8e81BOEGlLJENOOGCQ4kcLVX50rmE\\\\\\\\\\\\\\\/vrii7VqQNbtgxNEvX9GQbjm8nnx4ZFSB9Sc49lBcfQfIJliuhTacePT91SvgTnwHwamrKfvuMAoDwmmDhAAL6oi\\\\\\\\\\\\\\\/1yidnGSiVsYjbCkjWzRxQIxDQFDOmas\\\\\\\\\\\\\\\/uzWHbElLzklxQ4JSuWXnMbLFsc80puDPv6eJ4GSiPMXJJaHli94eILgNjUZen7El0eogrCwcZ1TM5EofcLs7SbdRgrf8GTumayeWL8ZyTwniry3zyLgaWg9RAvzMDlydz7qBrrMTs32rOxFlNGwII+Vdfi65ot3b3HoCdbpnV4DZacc4zRl2ajsR1bi9GJj6mB9SmYejJy\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/9+adqArL5f77xMt2haPAXTnIxPYcUanBsWS223m1K2ueth9KsKAB01vYt403cU\\\\\\\\\\\\\\\/bLukPTDCcHqoMw9yA0Xd4GDuKZKRqHMU3MradQOHj1ehsVoUcyvM5g2iiIQ1eIK45+h5Hq0a0zFQ9JIwlK7B4klf9WTN+ssNYlk4UeEwIYyY9X1ep2fWmlAMp+IbyLd\\\\\\\\\\\\\\\/prA+JaT3hcgQwXHCRt9YLz9\\\\\\\\\\\\\\\/17t0NVuNudgTiwQPlnzosLk4TczBec12RiZNVHfvyx7XhStcv+czMhUblECFFvTfd\\\\\\\\\\\\\\\/mAJwhrxMMUQeIuG2UAT9t6ssZeoi+fcWnr5TawThd6p2YRUGjyOzeE7Qz52PkC8d4cXepDiXrIWcYJOo1HzUD2cBnacY3diNvbjHpXde2MWQpcT5E90mAkrB1Ze3KThBCVABx+pSq8BIormPcjEK3Vw3\\\\\\\\\\\\\\\/BYi05v7+yr4ZykSs5TLpHGdfLFkGKY0nB0OS6YcIqtTx\\\\\\\\\\\\\\\/CTQ0\\\\\\\\\\\\\\\/n5DHgef+b5D1TRc9rD1Z7zAQx3jzUOkH2s7G20PA+Z1UnczA83GlGZe+OiiJ38dBWZfL8fGNq8lXXaa7DzfDobEDG7WmNCk8vali7Y+E8URRdzGtkFxw3yedsbNLmxb0HkcMo\\\\\\\\\\\\\\\/vh1gwQhJjx1cqybloY\\\\\\\\\\\\\\\/GjHept5Yr3rDmFwJveZT5mpzfhOUn3Yx9bEM\\\\\\\\\\\\\\\/eH5rD2AP2OdWhzdd5FtzYHQ1QFH8FuLKNUvGCg+LFtS3XU3B3XMwVA2rYYHulKGxKXoEDjjSNddHowDRgsFGcpajvhprr58Vlgs4Nw5semac8d73H7fdUhnXU+o1\\\\\\\\\\\\\\\/tc5sPBJA12Da3jj0fand1hhxatqhTtFVzm5OzkYJtRygWpFRBCXuEI5YpAk45SEW7sPs5Vnjl5hKD7FH3Jj3gziRIzMy\\\\\\\\\\\\\\\/zxt3OjKlAfaJHrYoejD6WgnwteHgpoxvbGyUyzfjfXm7mvw+lCfi19pjczu4TnvmGsuz2bxDwBsljHT9Z7KNcNqkLd7FOizjY95BJan+IO9WpyVuUch78SNzrzLUYl00R5d+bL1ikCK6lZPZ4Ejmc0PaIOaxQcDIVLPhsrQe4Z5S69v+pKTmjcngi\\\\\\\\\\\\\\\/BZxF1hCCQ9S6P9LPB27rK5xialg91WioL\\\\\\\\\\\\\\\/ozKoAnDYJxA4UzpeGRYkf83xXjiKZNtUVBMfIBFIypB0hgQ9O1Z1utGlfvmkhntvMJ8lLXO6t0BK5znM9oTzWL+\\\\\\\\\\\\\\\/riEkzoXxLisNUfeuB6Oa5Z1U7bGX4N1GJB7U2w=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022H3rIKSmJQ+Y8PNBL3f0sfA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022abcc4c7dc1352b0c973e1417a704f5bdb35b9e9240821075bc476784c6f77ced\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/12\\\/e002843.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/12\\\/e002843.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002843\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002843\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002843\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}