{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022UaGicjrSgMbzp15nUFm92viLuQzZdpgHrCYqSXin1Gy9HlxnaKFkkcOTioHMJ7Mhb2qyFX0psqsyJ9RLvKW+\\\\\\\\\\\\\\\/YIPqRdXhrIv3RWeAXbAKlMZ8Qz+BDH+DZmbBPq\\\\\\\\\\\\\\\/tZG6cvOgNs29Mpzth7BypuuIjYhRuvxNLb98Die\\\\\\\\\\\\\\\/UrXT9vW3Xh61grqP7EqIaCt5ls44AmD+8laB29OolwSinFuUAuysZeYry4HGdhLvTC0wxu8p8NAOqFjro3lwf4+F4HJL1iTwe9PqbMD0BGjxGiHiilTPglmdWDIWdymVwqXPciUEurm\\\\\\\\\\\\\\\/doscMkOfAV1Dj4NxcOK60me5BjFbYLE+4UfLvrh264AWxQvQAoo5I6m6Dp3M7F5MH2cinwmNf2QhuNTcCaRBfXtPf1lDcAdJNvqIz3lIRZB4jLpD1+Yq84FBHkHDOVKW+idK5AjooKreevKKA74aoXaSZCvw\\\\\\\\\\\\\\\/b\\\\\\\\\\\\\\\/chnmXg+nmClBuPFLLwp3wBSU\\\\\\\\\\\\\\\/J5j2yTbR+PH\\\\\\\\\\\\\\\/Nx39O8fN3yGP6QQCAYgQu1pRMEO4T2T6J+nC7ixN0OZgjlCVrHg34xkba8Y96kBpnku2SEvPcGspme+pbDaVf3xqith+64muNvdvztOasJaHGqLA8FjvXjEec6kVrqMWfrSy2iYRpgLcWnnpzZ56EUbKezBWN2x+FI2nh5B7JTuh5WJqCFyvE0mWw5CEQCoPZ4KXY6TQHd6NCo9iODD\\\\\\\\\\\\\\\/TP\\\\\\\\\\\\\\\/baXgAKMUTNyMo+qey4Lpw5b6LWhqmu+YnhmWOaDmA3IZ9K\\\\\\\\\\\\\\\/8uWE8uQa7AYvsJHnYbTyNvvJwe9Eoc0EXOTzG8ZU1t75awh1exx6dYp2+MEP6Jx3FUVZj\\\\\\\\\\\\\\\/iR7Y90ax+3nDfzbDdnANKJcNgExbreXubIBytx8htL+L7vutBbIu\\\\\\\\\\\\\\\/2YrPKvy8Y\\\\\\\\\\\\\\\/el6l7oxRSz2pucsYRW4mmfme+ruJijTrRBECCeT\\\\\\\\\\\\\\\/x5Snfd6747G\\\\\\\\\\\\\\\/8o2Z+KH3tL2dnsO+3WUaUOWeTEPMPX5JCwYBE2J0kHtZklKjhTSeZpeMSXvK5CidCOxDTnhkpQ5ctqKAToFfwu8G7G5aMi+YQjE4tfuEDyUyHIem+SGdg1kCaKVd2IihkEiDjkt7+HFfro09w+BemwkLlD7mJ2AskuUUrBVTkrgcdnx3WVhEai0P1N4ZpI51QTGkBGvuTtA+ugkl2400a1E3jFsu2dVYa49lMla4w7WtoYaFCWrwE3VlI2f4p\\\\\\\\\\\\\\\/icIjo5n6PWS1fgW33D9qVVX3Y3tMTut6LWmAdQKVfBByTk2HOkRIDj+4iQSBtBIMZU4iGH+pZpWo5o2xk5PQjOFDLx0F4xsaD0pk9MeyQ\\\\\\\\\\\\\\\/f+Q+5\\\\\\\\\\\\\\\/DM1cieBfUzd7X5N\\\\\\\\\\\\\\\/600fW6imWTUiRd7puQ0udbbJ7COZcgJsawiq3NrU7r7tINr9cb14uZyWubLVeQWCXoq6TT7KKcgDH44U8M\\\\\\\\\\\\\\\/gnSzUtGJCk3GbVx26lYl1U7UhRQ7HAA8GkFv10\\\\\\\\\\\\\\\/1sZzCyc1+rCxUmIG4Lh9EOvTxokHaDNLJjZq0sW0LmQ5bWRefowUeujzbiy6e0xB0uBRTCKUwdeU1x58oiiennl8Bx7smzLlCS2GicQbOM\\\\\\\\\\\\\\\/0W0k9zLii3SrllFC1jlN3MOELrAcFCYrubPDp6nL+wj4p2TeHyP0vFQiSau+OfIrlT+8HlVnUloeZND5clRt1CgV9sHt90rqyrIoUjd7jOD5LCNfMn+C3K8KOrb6NooZ6eF4aSyW1mbuBPdqfHCMDd4m4eISX3fLazgHos5kA\\\\\\\\\\\\\\\/qZr7ylN2pg73KnVIzxe+auqf+NfpVjRTaLHZzjHyV8lQ30UVnVgkSda79vGApHNXCrEheMbs2ky3T+3+v\\\\\\\\\\\\\\\/wx2mWurNhseg\\\\\\\\\\\\\\\/8rLqrkDjeD9qwZJtrofZn\\\\\\\\\\\\\\\/VJzLk\\\\\\\\\\\\\\\/013HL1EvOd9npoqqFUfdK17de48rJr\\\\\\\\\\\\\\\/hAE25Odub2cHII3KgrzShdffRwANOB3fGmgJ4+rvkrdns\\\\\\\\\\\\\\\/HrdJ2mmZxJA9uzd4q6dohVhpdlQEiJi\\\\\\\\\\\\\\\/SQxTngGlABbw\\\\\\\\\\\\\\\/5+4TYWbM+x3HEgDWrHbwUy3B9sxhy1ibizmRk4VEZupYHXEdBAsVSh5AY8ug6fqmAE\\\\\\\\\\\\\\\/gi3qYKvzPmA0Wbku8lerc5f\\\\\\\\\\\\\\\/5ZOY\\\\\\\\\\\\\\\/oo7Lbwso27Vd2QISDjtoImsd32Y+5zGPerRP05X71IWsznaXI2U52bVVzNEPkkm1Gx6caxbPkea4NsJV+Vz+bMIkYcAJFjhYmquEPekDxBpMGedapjjIAU7dOttqPfnC0S1gl5OwGe0Fq+3Z\\\\\\\\\\\\\\\/u561ye0WJTNCaNqj3TI0Fn8pfRVtIWVEn4oePozXdtWMuQB6pHMo51eyd1m4UTQRh442m83vLm9wtWd8RQS5mgl1KkN6NeHdkTCTwaqKIdLUrrkJvT7b8CoQ1xLFm4pePlfBZFm7wN6hla3WJL1SeRo9+roL\\\\\\\\\\\\\\\/r3t6IW6Xi+5pdpDDB+it7gyZm1\\\\\\\\\\\\\\\/7vf\\\\\\\\\\\\\\\/aqZ8sSBMnkTV+FLHZ4yYujN8fiu\\\\\\\\\\\\\\\/9vRgO2vYBg7nBUPBtCGCEbyPozYFgwdQfy7tWb\\\\\\\\\\\\\\\/tOmzHJjs5qnkH995eWr0nTdI03zej2MtM5NpcPXcu3rq8fwjxZhrLUN4iqV2ObN+ZJT2SQ+wXs5BWQs26FA+37xbFoBtIGDuRy1MugdPkd1+jabGiQR635VkZzr7402v+w8gDk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022r4IxHfYZmJe+7sMftIx1ow==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022b88459f6f13e1050fb4ef9be902fb72c9b4904a5f117768ae4117e7ea4e6b2d6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/12\\\/e003441.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/12\\\/e003441.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003441\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003441\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003441\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}