{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022dAinpSFas05IItzgzqxnrnEUI92YJk8f42l6imIXJQz5tW4wfk6Nkj6Tax1lHowDz+0rZqCC4\\\\\\\\\\\\\\\/1f8bS\\\\\\\\\\\\\\\/FYdib1HytwDyyS330M7I1a\\\\\\\\\\\\\\\/RV5xcdGFDuACyiw6kIfFyb+qIhqP32NxgKMm2UQWWlfA4anqlwiknMig8xFOS4V6D0qQAxEFu3Fu0V75X0dXy46K0Zj4EQN5d30Um+dqmMOt+cpA6uLRuWsoXjJA16yZVxdiXThhFEFlpQBtIdOZl0E2Sosw8A+N\\\\\\\\\\\\\\\/sKj2htlWSCLPcpxaaRFsQpw7caoHBj0022lofePkaqG3xGtcrfwA6eqdx70c15ekYn43eSaCzpWWq7vDzQAyWjgZrnUP6mDDMFI+eD2MoouoxgcjG490dYIDVhgApmmoz18bgg62USzyrX6ELIr99bKWx\\\\\\\\\\\\\\\/W8H+T5iOuBB3O\\\\\\\\\\\\\\\/jDzrihX5rT5aWybkPEQ8\\\\\\\\\\\\\\\/pEJw7xFQK8QWyKagcdvUj9LScFMLe71SUxpFX7DBiZ\\\\\\\\\\\\\\\/j8VLNpKCPwUxf8I2i\\\\\\\\\\\\\\\/1\\\\\\\\\\\\\\\/qgSx7deH\\\\\\\\\\\\\\\/2CsBRenZqasouzDHz50jI1vz5hZEQ9Fd\\\\\\\\\\\\\\\/chfWdysxKpkOthQZDtx6fFeeVCRuXEKj9vkthEzW3TWU4wUh6EvBPPYE3RF1fjYlhOy3ZLSU6ZIvHUq5apWrZY699DzNnrPyaCgjqWZG6hMdXxB8XQ4wFRTIaE4uldrtHcTaV\\\\\\\\\\\\\\\/M0XMYvN5gchmANqAVZR+BVMznulDUMEptd8A9oZzZRrsl1\\\\\\\\\\\\\\\/l4Z2dUFeDKtBXlqrYIJIhoGRBzUdsPO6oP+oL6Idn0QMloeiPaatmsi6VpqIeDm6fEzLSjOZEA\\\\\\\\\\\\\\\/F7tej0foRVCQFu7b9t33W98mLK5BBLx2OBYiUH42PitniGKc1\\\\\\\\\\\\\\\/oJw9ZhI0qeCIUrgDYxtpH1m0PJc15Wpu77lS+1p4ZsJm1CezNNuaKbKHcKGSrL6WVzLePM+PWGUiaVvfnXflaYMLnSeNn1OENVXd79UZpz933Gyiz0v3hcKXAAQFCPC3Q\\\\\\\\\\\\\\\/bwZbSlP8AzdurDW30ZNXVF9bjxt\\\\\\\\\\\\\\\/moKWAxfNUkU9ggIjAoLkP9N8zI18dAAh7H1FXJxlJICuARmasCkVfjAYG+rHy98e7gwaSz+47QAtxVTwvlbaRKhEQGoO3vylflDcmgy8n19N6rsX3t\\\\\\\\\\\\\\\/PDgARIwOeVkIv4Xx+0lMp2fmfaGZYFK4D5zoBadvgWwEJI79XhP6AMg2TMFSXxunh7t2AGY4vqnI8M3LuUTjGoQTDL9RishapoBFG1DTLFNB9OtDL2yqPu19LnXMMnxWHA7Vgbz21PjBf0nAcLhWwuj5SNrVID4pjYDOzSxc+LsNa9f7Xz2FEwJ8benBu9aTQKMc0ARatNDIZpLY11z3QyGmYikbp3B9e8I8kpz27XfllGxQ+vNFLwVvjveE1YyXSyBDmd+osNBE8CXxpaVPDUE5\\\\\\\\\\\\\\\/MZPIDGzh9hic5seAWs9sAf4UfZzZUdAsZRUgpxW3rGZC03RtbFVwBUw5PgTGKwq2Lr\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/XJ7KxjCjh0Q6IbTXq7XZ7waQ3coX0RbelkO1ApPLgqSWTOdkNTjQcChb6HArwJ8DxX6DkPmm1wKmwc3EPGmGGVUio5Dj7xHoFvStk3AT9hPjBQfktE1ykVcFrGEjfxsxRbSLGl08Pz7hvmPKf2hym59lN3J5D5ZWAoBE7IBS1iCq0OmoLF0w9p0hAFyM+VaEWAUL9VSIPNzbUBFnVnicfjbjj93HznsIV7evPciOzLO+A5o2c1FZ40sWhvH5+W3bEPDs+Ld4QB8SmCEqa04gS0bSb\\\\\\\\\\\\\\\/7MVCXPjXg15IMPF0eUHa7FRBbx09SRvB2Qi1a9MFQcuWX3LMoTlacHNtV+XBeJGicaYzbs1qeYC9KjvahICKfG2pq0Hc0RuDpn9mvKdzY2eC5mbGe\\\\\\\\\\\\\\\/j5g0A59z6k5ARuPC\\\\\\\\\\\\\\\/Nss6FAfsxOIZx6\\\\\\\\\\\\\\\/OkXtOU\\\\\\\\\\\\\\\/1JFm7J4d\\\\\\\\\\\\\\\/Vui+fi92\\\\\\\\\\\\\\\/t2SRVHxUrt+u\\\\\\\\\\\\\\\/B4mgeIlewhBD9MtSZ8LXx2JH6h9KJrtiZ\\\\\\\\\\\\\\\/GfHVxDCrRzf1\\\\\\\\\\\\\\\/KxdTZbZW6sMje4tBmmKEAq9e3lruEVQxOD97tYIs4irZ0J4ig\\\\\\\\\\\\\\\/HtWb9Zmmcnx5DWvT4wT1CA2X4PM\\\\\\\\\\\\\\\/1DRSYQMLrrpruwO1oSpfYiOzHzubh4+NDWqLDJx4Mk2PfumEdqeXDSk0Laya6JNpL8dSwQKrJkiWNu1ZR\\\\\\\\\\\\\\\/Ibk8aRd\\\\\\\\\\\\\\\/uYmbP1Ws3N7D0SaqTLgaJsskMUBFGsR0tC3Rc4e3+2AWZRZ6TMLsL4WGg3p4BdpErZvhivcR56+W3BAmcChJNAWDrS3jKWOTqfYLGdmJyNQ5SXG7nYfYN0qVVSV08RCJMFH1S62PSY2VIfUZxexNPxU3\\\\\\\\\\\\\\\/RLKJDj1P06O5Sa9xiCxiTresr3cmZyyJ6KLE+DQ0MTLjDyWqaFEKCSFZFzgZ8u5DqnJAH9aBpw8kJgdGz0KM5D6Cz6pGs8loneoyKorPQabzK0t1hj28+Nu7EAjXy2WnCU7I8eOUH\\\\\\\\\\\\\\\/9o\\\\\\\\\\\\\\\/URk9mUlLcq3RphBS7uuLmuY5qPSzO+vPZQh+Pnro+qU8K3uyeg2Adyk5NsA\\\\\\\\\\\\\\\/SDYdFrLh2LtxF\\\\\\\\\\\\\\\/SBVYLbdsq\\\\\\\\\\\\\\\/tdx+vQhqppdKgkiqqWU7KVTs2hflDoTbtqY5ppDhVH5hu+xkLHGhThyjog=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022R02szQBsfiKDJbP94aKECQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00223f64a2fcd3e89cfd05f0cb2873664d39f3884f20cd48a14d7c73e6cb7d108c2c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/12\\\/e003614.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/12\\\/e003614.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003614\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003614\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003614\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}