{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022TQ\\\\\\\\\\\\\\\/laYnFyRV80bwtgc7sWoRq4f2RqiXQ2LhEE7bO6oE+LqvyU5Mg3WLHajmWh+q\\\\\\\\\\\\\\\/vFc+1Vn8nFDR0xVlqnigJ237MsxnpbQ5ARHLdkgJ4Rjumw1Pk6di3JLVuxw4fu3542esrsigm28pnZ1blFpfjafM0VAXOoMIBapCk70PVVKjlnn\\\\\\\\\\\\\\\/NlN3OYzYJKgn\\\\\\\\\\\\\\\/Uw9cdzAnlB1RXqFogfDxWF7g3fJwBAAyUUbOg5\\\\\\\\\\\\\\\/63OyRiwiQTLGzwpYkRnCTjzh4qfsnl0gnQ0PWfFBoXhRAMA4hvQKdTgZl+BpARCxKu0vzBqzHLs1FEo83QWyDM421R9L2cuqCqPw8dA2fDEiMw1l53Pasm2DXh9+SgxwdNoKqz0rW1l+QLrBLBy4X3LKlAMe3DfzUbzMoYN4KnB95oXbZT\\\\\\\\\\\\\\\/0lTD0md7ObP\\\\\\\\\\\\\\\/IjiTW6umyYGLKzjiC\\\\\\\\\\\\\\\/3rTZ3dhl1GoL8X1cqR\\\\\\\\\\\\\\\/x+SfaR5BALMqmlkcWMzNCupMFT4mcnFKFUukUuwyLFh6mcp8uf4L9Wtsp31Lm8ctYEapbeOdTQi0GZ2aGOpUqZr1dKh3oaDOPeO9fFs\\\\\\\\\\\\\\\/IEK30ZgpJ2pAXyyE2FrRDvWsTQqjdCUu0D8N24QC7HhvzR9Dsvy1gEVk1PhX3D4REywHwJI5caPqM37283hAv5mxu3rohKc8yACwb2HECollDWn7OkZl8so2JedD5qbMoI93brvrOCMw1UdvGyLERWxx7wQTVpIReddBKG32KBEydVx49Vkm3EiRIoiFwtbUFs+ClWyZOSyHBmQeqxm2\\\\\\\\\\\\\\\/XnQTBYUqMKIZYf2jHR\\\\\\\\\\\\\\\/g9yh8ibCJKnOQWeFLKLd8lDZgO9BT\\\\\\\\\\\\\\\/bVFfFSC6kbO3shkafyBbxTTqSzoHFR2DgJ2nL1EFz0wtgOF1pOKUO2uNKCy94JXivh7SHdj\\\\\\\\\\\\\\\/HjaU1tO1Wo2yOebF2lYXrnu98YhdnSZJxLu+UnPT5y5iVcN1HH7ZAhZKIbLL9tMv3Mwcgki1q1NYtc14EMcb3Pwe3tRbyZajaAZB36ColrX8KSI03NpR2vZ2rR63XyGLJWGp3bkAmhPiGTVggxH7BQf+M3r8zbT9W7P7GuJpFyb0WwjPC9bJyEAzKDUVO9VFWaobjk5F1Tt1T4R9JCuKyMTjaOIeC3yBfkY27TXeq9e2ljgbZbBpYcVcS7t+0PIzYTZsapIc48J8ibeZM4iQ\\\\\\\\\\\\\\\/e8b5Q5FRlZm4b2NCykberL\\\\\\\\\\\\\\\/mhgAij4XFc1PowL9gs\\\\\\\\\\\\\\\/9f59w7bpXzflpW+d+Ppfr5F7rnuuHMrBDIGm1Ubj6Dbemfw+8W5gYJrjBMxD9dBWDdaO1D9vdySdH0ledrjZhs3UUfKvhHJe5fIKyMfTtBz92x0Oeycm+R44q\\\\\\\\\\\\\\\/q4V141iVtUbEwElXPA\\\\\\\\\\\\\\\/t7hOwRUQqU2yBibYd1jF58sKgBeXlbhC3vYf6JfNMl44imugJ3XQf8jJQGpZlNt+z\\\\\\\\\\\\\\\/yk6yqYOSip3w1ohU0HRF2qpG6LAGGxsKrAOLijLHTE31qeYCKDUOodZpZp52IwByQ0ez3KXD6Y4Y1GDvPzPUl4d7g6ksbXjfV+2DaA7RLE0gNRSPxlu7krBbU8KL9RCxaYHNEFFLHCVxHhVxkB3m1rgz26FfRknje1a8qOw8WsOZrT\\\\\\\\\\\\\\\/fhsbdV\\\\\\\\\\\\\\\/jCV37KIT5SVEaNxsgAzEt7OCUAfncDc8AaK17jYGEkclcq6PJpRAwTVTVnnXJ8rFyDPd59gunfArTXGMpIshVHPU1mpXOiBj6FQ\\\\\\\\\\\\\\\/a+tisI6La\\\\\\\\\\\\\\\/9we61hkIBy6fJl9cqN9XwwGZFY+pvyzQ+H27FbH\\\\\\\\\\\\\\\/Z6GP36tYFbOgsdGrVZTPcwlnuX1IVmI89XbkKju+GR3pGOmysTozlLLCPauUTGAQwyVJdEkRO6lhn1uwH\\\\\\\\\\\\\\\/9Ia+nK0wPTcYkDPuTGJaWRxwesNaS5zp75fUl95EqLS9U7C63Gw9D9+v5CRNlgYuyfAVNmIwMOYQkdTPVM09EUcwZ1tdWMDBF67DExjW6LaEsZyGuo0bipFwTm7GvLdjDn9etCCWTDy+6LC+zvLVaTfsKBrlmN3d2a4yR\\\\\\\\\\\\\\\/o4KA9kpT4UYySY8j22SY1Vy249wFyOJOgrbgHHWHU\\\\\\\\\\\\\\\/oChxJMah2HYNtFVfH59WnU2+PO5qSNCAuNwDph6pK1GmzW6SKWac146xt\\\\\\\\\\\\\\\/vhFsP1\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/BrpNjJSFra8MBKOV435O8mBys8OitV\\\\\\\\\\\\\\\/MTeF5\\\\\\\\\\\\\\\/RHRnnVH8q\\\\\\\\\\\\\\\/yOGKdKao7p0rGH7\\\\\\\\\\\\\\\/+bLiaQ+hqQeUZSQBNZ84UuuQV2a8C7939Dj0z1ZhvQEpYkqGDVjoCR3jmHCLTVYLJioKwQ8Z2D8aFVnfo\\\\\\\\\\\\\\\/tQVzPMIZrKowUuHdmvi+RvXomVaZDuehR+TDx5Xmt8ytiHnsQMg1cI9j8UCrzJ0yUXAACrxpQcDEME7RjjdAT9tH4VCq9hhQ2nSzd3LQLt65OgrsbnTjyzKx6L7G3V3BwLi4tpiIvjyBOpAQttMNQWOUCNyIpcIJrIXeYAVFwgk30wwVuTJaVzRXBtcNE+jXW\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/N3FV4WUY42PnDw++Ty95e7\\\\\\\\\\\\\\\/lz6GFlk+Vl6BNJRdtdoAtPKUhiIjZRd2OswvsoCiVogcet9Pg9fb\\\\\\\\\\\\\\\/f56EinAGueWBE6gM8X7X4oMNKaI0nUUsA4n8W5emtTxtXiD\\\\\\\\\\\\\\\/O+4+x1vmCyVZEWo+8w8NkjzZIBJFTsY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022kxVzpMS8XdeQ\\\\\\\\\\\\\\\/F9cgg1KUg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022aa314abafe8c02f9fb2d27a36a9399ad9a36e385f921fde308fbfab8a7afc8b4\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/12\\\/e003414.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/12\\\/e003414.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003414\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003414\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003414\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}