{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022arl\\\\\\\\\\\\\\\/9ikfqVD4NodSkBzzCmCopV4NnIhuiEukEA4Xv2QMFRKRk9qTx04WaLhOjCQqIRJljRjpfgJ+jwIgFHuoKZ7Z634aqlfUt2HFsZJWO9YAUZgEf7\\\\\\\\\\\\\\\/woO7TudxRMUMOuRw+Z2Vi5HRjYQ9k+ji2FKvDRT2P9tVNFVTmBCtUiGoPbjkluNEYDG5tjmyAnCFRkgrdBjh5n\\\\\\\\\\\\\\\/U6J8H4Mu8MFRskHovZzzDMB0DB65liX0IIsgZZwWASjFU5tPdyOQBlS+qoQ+0IlvLSZeq\\\\\\\\\\\\\\\/iuktCLZS2C+8UwXZnWqd3pugMRFhR9LLOmDXnACTaWQ3nhwMqYWxQB2a7SktTYX6ZfZlglp1YeJVGqXsGlnfEf+1o5zt3JVFyCPBSMcomGJi0Yv6uoMkX2MruciEt69\\\\\\\\\\\\\\\/awql282L00mUbE\\\\\\\\\\\\\\\/t5oEb81ohe80ykCtOlXnCdzDQL3rw2GrWRJm8AEjOa2csleKIA7FmmIsfpxkrMVPybev+8Asv5yrxQmUBQAIQOmuJzWssNYkyLlz7XwM7+BhE+hPxQ1qAHrS37H1HQthoeCjXvvXb6cbccpXAwzfBS\\\\\\\\\\\\\\\/f\\\\\\\\\\\\\\\/KVpwvSzHMimKlBc3OxnNT2BxADM43+pF4fnF7WjXWPXBn3mG1oJgz1AHJagpHvdDfCngMCAS89vWrvXir5SMZIUfkOH\\\\\\\\\\\\\\\/oKXAZ489uLRcv7e+f5pPCICV3Cm6CpfS0+Mkw0wcvMn6QjyF8aQ5uoyNfo7FcjoC7h4pTKXeea5nsGTheLNmp\\\\\\\\\\\\\\\/uHHsG2JJUMTtcCp0QCSVy6ssNFhzOsbmhuwx5d16+e3RhfYIsdFtnyaDuwMGXoUG4IUZRQBLFtZ+6ZDPs\\\\\\\\\\\\\\\/KwiOWFyV+t2laYuHBgaSN7TKkKl6h09j7ks7TDoDelagiCR8hKt7tkN52p1XUO\\\\\\\\\\\\\\\/K9sYZVw+gDsf19iC7ZOkixPXRxpYyTkqVbsQpF4Ftv6P2gPVBUj8N4qQRb\\\\\\\\\\\\\\\/JN0LtbHU0Q7Fqp6GD3A9ey6x3lnO3XW2YpgJwSZ1EUzGmi2iEhd+kMlbIFqIvKICLKBT8kM5qnA8QQCZy86XCVTTIR4eZB+sewaw+kQfDSDwZFvi7q1a3GiXLHTsnqXABtxAH8mY9rnUmi2PVGYbnF1pfzTUYsOcAsFr1vvwTYGWPRBGo7lgVOTIBZcKmUCHz0TS+d7xutmWI44Gq+jf4x8PxIR5kQheIGRewmg97tYx3I2fuBgWRnu6hdLsNaYP\\\\\\\\\\\\\\\/XsN12LE1jsQ7ZOZiTpME9Lzi6mpy+OiuW0S1DrmqwEf\\\\\\\\\\\\\\\/A60wvZBoQBIwSlScOih8zBAaxGP2qtILJ4AjXbxqT2133+WWCfH51jPcMb8ObOngs8mpaISnctZteYDdgd49zNk\\\\\\\\\\\\\\\/K6NruXvnE\\\\\\\\\\\\\\\/2NEEC2Ehkfxyz4j3tw180AKrGhaj1paCDH5lmL04\\\\\\\\\\\\\\\/Rv34qPzD9imOE8wS3JX2xCyDSfs3tkuYKf3RmvdUYM9abfrBDU+Cbx10pht2afG7iHv8HPFJGHm+3EdMpoYJY1FElNaLjWBCEh2HgDvNj3g66Unki4sl\\\\\\\\\\\\\\\/IPzEtSIxWN3VXwr3Q1l1SxmRrmc7rpokP\\\\\\\\\\\\\\\/XMuok9bH0mTECssNIPvv43mntpRd77+ENQ3jd63tsXCQNv2i8D5wkoCTT6va848CGMwOte8jF6KIXtopxSE3Z\\\\\\\\\\\\\\\/vSUkT4iaz1tt5qbM5peN\\\\\\\\\\\\\\\/AopQ80tQE1Zt31fiWeiWes77C2nrXyZpCG0YF23Mv1uZOEjRpoQwm4AbLyW8vO7UQoLFvJUz3vMgVOCJ1BoKRKic19P2hLW8EmBBkuLd8jjrA56TKe78cEuJ22zwPI+88GOzIm\\\\\\\\\\\\\\\/9B8Iy1I0Nn\\\\\\\\\\\\\\\/YZydPDmmwcuV4Sz8PlUiGacaHdSdm7rHyWZ\\\\\\\\\\\\\\\/kjK2ROOQgPHrZovr40CWKY1aQ4Bt7Af6hkRznF11L0NbMKwu6dC8Dcud\\\\\\\\\\\\\\\/5eF9cONyVJ5Mq3DD1uK3N0U+jShJ8tkGjNzo+xN81r5a2FqQw\\\\\\\\\\\\\\\/cJk58t7wgYDGVUb3GN3RxudmfFdVWaDn+lG749YMQrAy6HdmlBnsLMa57PoN5929jKB8C8G74Jli28Mc3gcEyNQ1BLo5v3KNow+Nsv0\\\\\\\\\\\\\\\/9BupT2ZzL4sXxg4KZE\\\\\\\\\\\\\\\/fgoW60KDZVyMLLx5ZMJoRZ85lpefrsRZi4vgGf8L0Fgzg8g\\\\\\\\\\\\\\\/XScZ7va7BnnXfpmMyiZeMen3NZxMuk6vXvFMAtDCocz6tD11Q7xP\\\\\\\\\\\\\\\/HjrfH4UrGRpVS4hSqrX\\\\\\\\\\\\\\\/QGIgAykTFCkzJmuIeq4adZlQnddDZ0zOj7dBSSe5nOuyDEQlqkbntSwmj4nE6VYLygDl9HPDmweCZQh5UymSvgWB6quv0IG53PFwJdxlmph31Y6EcSRsH5CjdoJxUqAa+3rIA5aTyGWOD3fme68g9xNGz1FsWfC70ByrjZAcnhr+0DbHf9pjjaYWG2tFE8CR7js3evc\\\\\\\\\\\\\\\/iNROdfpSTKa\\\\\\\\\\\\\\\/CUoyGqOC1FhaV47oM2KcU5xhxdzKzP13fY6Sh+cuQm1ppnJq+kB7qZLxXJ0CcGTHMyibLTtjQXE2axSPmgx2uFMM9smORw\\\\\\\\\\\\\\\/XF4dJpO377FeV1vOz1Q9WVm\\\\\\\\\\\\\\\/acOOFI23YLQ9Tmmatg0+Ftl53iCBpZlBcCslWnKdxy2AW5kXOYbmawmJ1\\\\\\\\\\\\\\\/TB9nI+eFWccaHDfuY6fYGX51sK6imkTRk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00221lpBDPpXUVOIuq1k+1Gauw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fd98da270283cd642e185dab84e5ea04948e23aaa2dca180ff0ce270301bd36c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/12\\\/e003176.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/12\\\/e003176.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003176\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003176\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003176\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}