{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022JqaaOdItWHFUrknEuURZOVKR9T9nAWAHAYJ3raUYULzlCPCf7fC4Ez2XYAr2Zar+Aujdgw\\\\\\\\\\\\\\\/4BBikji32h+rbe2Hcnhq0eEuMMbzFOKWKCGShh7wNeZXaWh8pZx3enwr4aV9W1vsohBZWkiG99P37gbSkkN6MKYgWOSVd00sKmzrcH1LvjAe65PFjpY1R2sqPZ2ZuBv\\\\\\\\\\\\\\\/W0ZanbHiSNtxgpoa6HF4DyWs24KLHTPPGkrCt3o7YQWZhgjWOGscDUwX0iLCzJsfhogFuzj4pYXcspB494hixyUXxxXrDCzIDAEdh7967BU0ARdLs2Ndv2j9\\\\\\\\\\\\\\\/yBPUqrJp2jBQU6ZgPf8oKut2fcF47C8Uhbd9fR2Sa\\\\\\\\\\\\\\\/VZrez0WC79PxEMJR+7NG9e8RupoXDQs20b+gviwYmWSxJH0HS2LhbvW2x9KHCYPt\\\\\\\\\\\\\\\/4uyGXz0O0zB+Xe\\\\\\\\\\\\\\\/vZ4liN4W4CON\\\\\\\\\\\\\\\/jQ4Cn8Baco0OUv4qw\\\\\\\\\\\\\\\/Xzp40+rg\\\\\\\\\\\\\\\/olS5d2sx6Wz80tQm4GzHjD4hTK2UD40CN+i\\\\\\\\\\\\\\\/VxOWck4026svK4uqcUvZuxX6YV1f4OSjLej3BnnFYtGhvOxTZ\\\\\\\\\\\\\\\/oFp1YI1Huh9VHAniiw+JyNUMatrzfmp3jfIT0QFlLdJ6V\\\\\\\\\\\\\\\/ylFf4KXjoW7KMHJ0YwUAaMIlImb6h\\\\\\\\\\\\\\\/9Fmvd+zgw5OSXj4Aemi9eSgTUPTRFbHU5BKgaOvMMqd4YnPmGWaHuz1IAsjkGndUNv0pv1mA3e59Smn+duYyCZ\\\\\\\\\\\\\\\/ku8qPzc\\\\\\\\\\\\\\\/LoAYfkCHnrgS6KsWWlD6BzyN6VhV+hWEmlgmgdzwsoS\\\\\\\\\\\\\\\/QLEzf\\\\\\\\\\\\\\\/yavMFhibFOEt2U8mOC13YN2btJq4vxdusVYn2gl4nlNEUuxolXcf+0Stb2GDfD20qtC8\\\\\\\\\\\\\\\/B9tJZ6DcubyeP6qivqg0\\\\\\\\\\\\\\\/tFtvKxp5YEoOJu\\\\\\\\\\\\\\\/BqPcBHgo5sygWNgLtJsa+E3bicUCNwPV+muDbrO4Cughp9dBYUQUWN0oraTMvtoCrUe8zxe+PsxvseC86O\\\\\\\\\\\\\\\/cO0V1i1LKjdCnwfV5QRPSf5ho2nxMPKwN88kXq1Oz4kCSgmP+e+kGTleCwXQH2ZUDjfGn2TH2tixboSBP+lE+pTXIrClvn0v4EDaX5YJb1MwW7Nug4yQa8klYP4WzBD1xkqSxlHIv1oboGTxaUFgEJ7HsgxoR3Iu6iXBQUUXnGeC9htjNqBHe7XcDbLLFKFdbeBdNaRzA18aZCi+WBAVULnPwLpbR\\\\\\\\\\\\\\\/b0lZ3BTtAvE8TwzlU5JvMpGy5+XqfAx73\\\\\\\\\\\\\\\/xfXanku+YjRMdA74XkkNaDl8P0rAvQ7bugWdhVB5JCykIFMolkqFX58vmk6YUYGVVzPByo5BxNNlamuIjSAplP5+eoAVXPWNs6oY56D1kGVC\\\\\\\\\\\\\\\/MODDye7sS12EzIriNOs15Leiy58L8ytMfS1W2S0GAicqDtZYQNwqSfJn38blW\\\\\\\\\\\\\\\/3stWYK2ottVv8ruiKXxnrJQeMvPS3C40tKGUXkqhUCXxkppGzl7LU0mK9dxseA1VfWP1OTB8WIiB59fgi55UmCibByo4X788Ca10TLMYdLvp2AE5shkmKMCy21IKzaFRYIK71cwZqpWc1WGBps+ie9t\\\\\\\\\\\\\\\/d5v8Wu9d3A4wda22CZsmi84JMCRDn2Hg3tdAhQFXbN1Ja3VZJfL2lHEUPdvHzckasnVK++0KALjrKofJoVEf1sAzOgh1egG3p1QJU+zU3OvVacCUt1v7g51XXJ6gwgRVbN2e6kwaiEo3RvNrznZY\\\\\\\\\\\\\\\/qfvb\\\\\\\\\\\\\\\/O3x5DZQUdTv9nKLqypkX5GQppfoIHdt9rA+nC3vHEdhvzFiN0xoDhz\\\\\\\\\\\\\\\/8hE5cybSztjIPvLtICD\\\\\\\\\\\\\\\/cSFmCPiZf80mN3Cj0oKwfb3NfUNQhbgQJkWK8cqBzKdQGPgPMa6KVdsGNezmoeSGM07q6BBKj9AXmBgsQDVhMqC7flqqS18TYYCwf5k83MGZ9HnqTOIHK2ETfAgtRMqRxlcNNWzdYd+8DgRNyCAToMD6jKcX5Ndy\\\\\\\\\\\\\\\/gobhEm8G6QrCRogzFG0Hbjm31t\\\\\\\\\\\\\\\/VnekTtliWsybytZHlIEXxiF+Xt+kILUlkXrGDP2es0RCr5MwlUlSbc8f1DFOk2KuS02E84c9xlkEOYSQxwCIozM0vrILK3mzJgK3wMh6oo2zC\\\\\\\\\\\\\\\/YPezz6tyFtoVkVE88vyGwjC65fEEcL5ehnetfOEf5pUSF1lA6p5Y\\\\\\\\\\\\\\\/TAA3AIuSaleVWjldfJ1ChXSU03n8gbs3L4n8QK6zUk55LePx9Ho7YXY49U+mLtAUwWigypiumizQ0xtKUPesELIeizG9jMg\\\\\\\\\\\\\\\/Uunay9gy6j3jC18K7gU9WUDKkVF6lXNa3S69hEnsmbdG+8kwB12IxymtJTt0saiqiOz9KtEGY3\\\\\\\\\\\\\\\/11vHtbpyvNe2Rj3Aks\\\\\\\\\\\\\\\/SvMPn5jK9nAtgrJWrqe889txQ7wGr79Uxuh+YFDizYO\\\\\\\\\\\\\\\/yQwtnSKhT4fyeCQOeXTUE23cptLylLrq1JtNodSyVtxUzFT\\\\\\\\\\\\\\\/YwtWzr8G0KD\\\\\\\\\\\\\\\/k1i0TjdVcIS1wqoO1cGh3IznBfCM9iVERL2gg+0PH4JjsDIx9D1IHk8a5PWxmOOTQnJjeN1X6927pv65Z9WhfAZMFBhNGOJyRK9V3+bra10uTLcHvTMdPWhFwYid\\\\\\\\\\\\\\\/fOQIYkQyouiHdWgZAQNhWcYOcNZYGxoqN6WALn\\\\\\\\\\\\\\\/k73PSjTp4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022E4zmXuMFqCyvT41J4qwBtQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ed29a1882c95f2e28cc2cf5f0a412435247bd10a2956acea2f55ab2e01ecb082\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/11\\\/e003224.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/11\\\/e003224.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003224\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003224\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003224\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}