{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ARLUgw3DuJ\\\\\\\\\\\\\\\/I1LocN76qufmnPDlWyu6PJScRFgpWxaMhp\\\\\\\\\\\\\\\/7laAWp2cps9kBPi5SpcQEKzDTnA1V9pHDNhu6MMFDoWLngj\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/J5pT7lsFdh19cu3oxYTLCEFrxT0T0HKPt6G7VD28y+ICTrcLkW64UCjlVDBkZvNJugHBDxgojAnMeAakZJALI6bJnx\\\\\\\\\\\\\\\/08ZJOpTwisocsueZ1zzjLBWOAhRTCVhatJB8ttwkxdsl2quKiZ6go2pWDfZ0O5dvL5sOMhb2poK46ghRh+xqkDlUhG5Be\\\\\\\\\\\\\\\/06m\\\\\\\\\\\\\\\/g\\\\\\\\\\\\\\\/EM56CYih1FU1gnMgCzwLiLx7VUV5sLqrRjZ2ttP9ufMJZOkGRvq6PRVzBD+lJpMs9Xxi6kyH7eucJ2BvqAupGywB26jvdRGuwK36Gfw96rw7AXvKB5MWPXETADQqj9wV83Uf+qkY31C7K6aX2y2YWAAMCnF37mOO+seANt5AmpJF\\\\\\\\\\\\\\\/t66gXx6vMUD9OiDhbrEtKKfsSkqvBMVU+2ixTPcVBXb1IrsBslAz3FDXvdj4i4epk8LdmJhVmAB+H76tzC6lQXo0hWaOG6\\\\\\\\\\\\\\\/Fr6\\\\\\\\\\\\\\\/p\\\\\\\\\\\\\\\/TioYTvWEGjfxkKbWspD5eU4gqQo+\\\\\\\\\\\\\\\/W+CSJhHDb3pLWw7ZVhHvJPWEexmfGXd7KI7xm6EwHlIKKL8KeS6QQEzIwFGWH0aHf0k8Z2JsABn0rRMEYE+tDEE+yElYEjFX3+A+pqE0JTO7g5KU0C\\\\\\\\\\\\\\\/0NrWkJGsfBfE\\\\\\\\\\\\\\\/lo1lQcgtXcWgWjccCybkqwVoVOZDQNBy6ExTAwn5Eok4KIBS5hV2EmfVg+mnt4ZJa6IpBZEVplrpA0YscMOKnLQ5LBNRS7D4ZbKB7HitWZ782QWeqyPXLsTFrHFIVbt\\\\\\\\\\\\\\\/w\\\\\\\\\\\\\\\/RT9PEYkNrX8Ithz0exG+hH\\\\\\\\\\\\\\\/9K4h1V07CcYaWfWV\\\\\\\\\\\\\\\/1nFasw8TNmmwQEwpISD4oT3kmAjcHgouxbPrdW4JXv1ZuVD2q9gSYwKfaDf4+vAGEKvA4sQWw3b9lXI0AJHXzieEcbEYeMM11rX3uhN0ZmJkjhdrxtY5q8tBlRIIzOt9vqCqWft\\\\\\\\\\\\\\\/d3M9lgYiGpXU3ntV93NYxGA6qmCpwxbiDXmu4Da+\\\\\\\\\\\\\\\/6VT0f60GF9Up213v24e4n9Bz7++LZI9b\\\\\\\\\\\\\\\/otJfydLZDl5+UrTalkSmOSajNTeU3RdSXsvq0SV5dN4ofoZuqeRfiOdEysEUxcatLZHMAre1QMyVAgAP62GKttpJQXvelB7tnEjCOYgAc0XIpcGDNGsqt5oREJtPdqhybF5lanNI0mgs850kc2JFbQ\\\\\\\\\\\\\\\/bbmfX10op3z0IqGqhnd97Iuq\\\\\\\\\\\\\\\/4ROhDZMq6S\\\\\\\\\\\\\\\/RYsCa1ULCJor6FzdSPnBfS9noT5PFhcUE5rvi\\\\\\\\\\\\\\\/X1yw\\\\\\\\\\\\\\\/B2ZcxjrP4zYxZAlDiIKZButRmSVUMOTTDrEKkXxXj0sOp2DGBLxizKKcNdTcOcQNaoEvEY7Eu9C8JgkzxD1ej7NgS6hj4ZkI+4uVadZAjv42gN5427Hs54dQ9C6cJT8ro23v7duqtmFdGthDHM2l9OLA5ql2wnixy\\\\\\\\\\\\\\\/G1uglMNORNFoc6rVWt1bt5moZgzbjPgSLLl2W6BcYF8yV++UKLLFJMvTLw\\\\\\\\\\\\\\\/CA4snyUfLMV3s68Tc+Lsj6dzIYLRpIDdh4D7TEJecFIL4lZPElElJmlZ6FgHmw9AZxXFkLWAsMGuOQJMppb6t4pBiIy2Vg8rDYRNuopkpXdi\\\\\\\\\\\\\\\/pz3X+zaSA+FLg\\\\\\\\\\\\\\\/jNVIz2v4fEriPV6P7dp4XiVlJZjbXyZokxZs9MTXn4SKByVyjpi86SndoG5WPEC9PQ3Y7Gebn5E4ifGCcaYssl4w2dXloE2b\\\\\\\\\\\\\\\/lTKzw3lzErjgrlEW7OWK2d82Ydiyop66NXLi\\\\\\\\\\\\\\\/Rn+FdtPBhRbQREStu0+XwD1AlJpqIdkeRcy8ql+XYn1Rdv4hZqW4TvL\\\\\\\\\\\\\\\/iC8BhFTAHL3t\\\\\\\\\\\\\\\/0e1XAaWiQN12SuNr3zNJomJdOv72mJBGKe7O7CNXzNlkMfabKWqUjVHU6qJXz6ofgXqHl3ANyymhfwGGcREQdg1\\\\\\\\\\\\\\\/tzsaj01Y0UUsjwq0FFb71+Cab4mCZhMi3hIvG66Kw83LpgVRKkVglA7fLDlzjzlo+XLUYL0uBZJaut9\\\\\\\\\\\\\\\/TunnytCIEuZtcqLPMGZneGoNvtGd+7VxqLYFurRYLbGML0gRTNWmH\\\\\\\\\\\\\\\/poRATz6q5vdf84KN8VlCkOxo4CLDOX073LBJI3ilgtd7pehCFetOy5h3noaJTyRBDYoYM+F8hHa9g6GFPK+msjETVFSwGcowgvOfxkDVDHANhwJUnMIEJJAS97aW2Nxbr1NsDSC5WpM\\\\\\\\\\\\\\\/p+ONTnXu2fgvRw6tI4PASO4bio1bIGhXGgfgcjw2QnjSNEk0bJccLIGA\\\\\\\\\\\\\\\/yRRLeJGs\\\\\\\\\\\\\\\/HfpNY5rEWvqBMSyKeIdfCpMx+dVAbz26HCinhU\\\\\\\\\\\\\\\/OFTuPkoMWh5f0xmu6Im\\\\\\\\\\\\\\\/nPk+44xkx3+kIXjthFIyHFZCcP7L4bbBwd4dXNMEXZqJx3G19hvbni9vhIfOt\\\\\\\\\\\\\\\/n0lry0ZgTyeJ2YYzGOS6CzPApVQ9oX8spheIoiImbtED2MutQg72uiph5cIa5QvLZrBEFh7GbF\\\\\\\\\\\\\\\/zwaDITu\\\\\\\\\\\\\\\/vYxMYwywtX51ldm28PYZiAQppfWajZfV+bYrgznqZw7ALBAUm4rBTz+5i4ccupAyXTzwd96t2\\\\\\\\\\\\\\\/B1rfn7ZfpMKAwm3IePPq2fE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022xBW0XpQqqHUXQqWQopCv2Q==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022ec0d9dbf53008a2e1f56d734988ca8511e322f2e4b9ff916d8b51fd5e1f563ce\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/11\\\/e003237.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/11\\\/e003237.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003237\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003237\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003237\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}