{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022h8b0aDjE4FWo1KKcAQUyRGJrz\\\\\\\\\\\\\\\/KmYUzrnfR9PgYlvo2n3uAfHJOPy16DXya7xVsEr4b9gNRwYfzsTF4yLAKw\\\\\\\\\\\\\\\/UfkOV0xazjbJIKLm4nvCtMGJAdZAKI9ubdBVOZTefdrDmFWobdTt6liWiusaseNJsKGH1z4s56LKlUGx4QZMGDPLERNRBN7+eeIyPtC\\\\\\\\\\\\\\\/Zu54LDzNkW3CZQnxSO4felQMDdQCQE+VwGW3lVO7eNneThh31kTAGmOq8rrr\\\\\\\\\\\\\\\/n\\\\\\\\\\\\\\\/qtnnBd+oqp+aTDXHLM5PVlya9RcpxsYmfHcwWOoEmHIbM+lNq6hWjCkRQsT6EIAkJ3cxgeecbxeRuVUzu0nG7njA4ueU2G17IgZ79Zg0ZHeg27J79TvoFrSItdmrJgGH0egBEwoZ2V\\\\\\\\\\\\\\\/SGOsx3KG4ntlJ891qFk5JjMg4818HxTy5fpx1klFihfkJngpDOdcdQgHlyYaW3CGV15Qo4OwB3osLZfUAe+HFKBzs80QzeiP0GLm9M0UAGvWup4jH9kvrOtKxt0Tvs77ixjKw6rKuh2V8qOFQTq1rszXMHKTu1Kf2wKDNfSXacHgNPuOAn3IrG2\\\\\\\\\\\\\\\/Xx+PyMn2zKXVhlK7RQ40DzAMSwbv6nBsT8wehfbxJDPBdL9osjJpILY9n\\\\\\\\\\\\\\\/AxPf1fCoo8iiDrjsIng1ePzsostofiZz0pZgjKhgqQ\\\\\\\\\\\\\\\/NcRf3dzCysNGdFd5rtJM8aq\\\\\\\\\\\\\\\/aPOEIT337acxVNgaw098J7JVIOyVoiir33rE51YQOdSCzX8\\\\\\\\\\\\\\\/mLU1cPKspe5oRv\\\\\\\\\\\\\\\/3ZDI9\\\\\\\\\\\\\\\/9ytd7TLWX5Fhd\\\\\\\\\\\\\\\/YM7MfCxwbj4Ze7aNbSttku6LglHk1Z4GosFRDtqQESN6rEC3evKQTiBt3saNrtfMJs\\\\\\\\\\\\\\\/16zC\\\\\\\\\\\\\\\/2vB9vbYSEY6ec8DLtMu+Ba72hOlqR9YrVxicBVP+Z4xjlJFlSknW+3OV\\\\\\\\\\\\\\\/y84QNcgCmMmv3rXtQN2yRFEQEIETNP7ZtzAPSis+f1tNH5ycSYlPIswyWkPFpCEyXC4EdOIaJ4KaFO3Lhtiarm34Kb1SgqJhY0zVYC\\\\\\\\\\\\\\\/hHn0fPHDPyonVrVX3m3\\\\\\\\\\\\\\\/+0SPwJcpKfA7xFgti4+fW8W0w9ZOAxfuu9DjRmyMxOdJ0XwVZjOnktMffAUmFA0dIo26iA14yBeCrwIzd4mnULWzdYV0Ue3khDVVhPGAvoEL3NG9yxJhGsVoShhkxAitku4ojecaaQeMDVdQOJ2k3zZgZMWVmixgEZWhp1\\\\\\\\\\\\\\\/2R0GAjy+GDiaheSLUBZHBZv9UvvBKVYXBch5ytdhKTnRcDI80ceJLlFdMTO7ELAeu9QyG2ErXYZ3nSevlG+e4EMAraFnaBtE7r\\\\\\\\\\\\\\\/eDawMP2baVnXL0h0wH9FOVud212nZTL9sFsD59zdUxDonD7GQay5ylo+zNZplJG1+JuHSwz9vHE8Dr9DaTu7r7uaSCzJUBJHG7t7Gr\\\\\\\\\\\\\\\/yJvQPbjC9CNqoC2vMx3qu6nGXHX8t7SpP\\\\\\\\\\\\\\\/jY136lbor0arZvHT14HhUhjNdk3uQtOnw1Yhj8IRQ1mAhkqTN2sJXAx3mowfi34rEDUUD\\\\\\\\\\\\\\\/C+bQGDW5BM0iSTLq2sIFmQepE6ydlJS2WUMvYXvEsj\\\\\\\\\\\\\\\/G8IxcJeL\\\\\\\\\\\\\\\/Q+rK4EvrsHo\\\\\\\\\\\\\\\/ZHXTAgtGXXy3CWJ1NuvE9HhEiEMLnk6hlPH4McWJsT92Le\\\\\\\\\\\\\\\/4Q\\\\\\\\\\\\\\\/rvCV9T9K8H3Y49ouwP0SO5S2iRO7XMrPE74XWg4Fa4T7wDHFfPL8ewSb2LycNUcsDV8i4wmrOnyJA754XqtBwzMoV8EFwC5dCuV1r2k+QqRVN2xCfS\\\\\\\\\\\\\\\/WcrrZplgJ4OwfTl2xN9b4JgvUgrd7DK2XlnVxWhsc0VUlfbjQZpj3M8+ulh74vRqNvbKbCbJk5m0w\\\\\\\\\\\\\\\/aTJrcEZoaWYzEuK0SUTQJFKUuYLolPzu1eVbipbqcStaQ30CK9ATQAaRee56XkQxI974F+VYSoxuNLiOP2iB2YOUbNj76Dz+RRe23HsNeaFMgF3pQyduL93dE9y66BiY6VRLDWtpyQd09ZNU4N8v+1zW3LWbq+69RErM\\\\\\\\\\\\\\\/2sV1rFYXP5NTrfxlt48E2SXjR74yr+TbDRWZiZLy4XWG7xQ1eA29wgRsm\\\\\\\\\\\\\\\/3L6kYDYC3mNiNOCODuCUl\\\\\\\\\\\\\\\/S8cPHcJ7AwWwdjEuw2HjCEe5vcFdbLMwpz3JJ8Qct8oA7fCvw+Fd3O\\\\\\\\\\\\\\\/o\\\\\\\\\\\\\\\/sMEMm9aUCXvMIKyZgAeRDpeeL+C8M6O9T+JMC\\\\\\\\\\\\\\\/VM+DCNYpWusL52yjmfy2941BXxvBPRPjhRVbes5NP4kyCpDVm\\\\\\\\\\\\\\\/oL1cpL45\\\\\\\\\\\\\\\/kR8zSxYbtGFODPLIoIPFuxs1iTVqKfgeQDq6OwkIMeNqgStYtFK+a+HEdtcG8dy4xkLriAH2HfLJmfRUDdGgJj8\\\\\\\\\\\\\\\/T5Uh\\\\\\\\\\\\\\\/+jPPAUP6hwrob5YwMlWriS7y+6DWqORJosoHlX\\\\\\\\\\\\\\\/PJHhEUi5zOiQYzmy9Q6Vz9Rk8mZUNyrODLnioAWIHGiEtYXL6BpjtSCFN0Rroe4L8flFSE5+\\\\\\\\\\\\\\\/O9oNgNjBv6LHKEHf2rOePnorBTXXctminBfk7oIImVhT\\\\\\\\\\\\\\\/UyAXrKd1HYd3vAaatyg4AxoNn1qgKmsxq3RKgLJ7I2HNcZITRbdcwnZ80WbqoGDPkPrD94u6M6y3YVSpKrXgFDcueqhmItOuGw7KngblHN6JoaupVWNqXItbxJSJ+RcZvurWcLq8DF0=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229Jptz\\\\\\\\\\\\\\\/M5NMwxx\\\\\\\\\\\\\\\/+xK9HjEg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224cf2788c6cf9486928ef83bce36c63c234cfa7da45540ab955000e9864361ebd\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/11\\\/e003065.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/11\\\/e003065.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003065\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003065\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003065\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}