{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022av5Fx9zaLaokigJTKba1pKYepYfA3Pf8eYJrK1GoRwFcTyGJLf0PQjB2JRC7aS8uGxIZnzj25G6hvrMXjswufGXEwq7OQ7t4kw\\\\\\\\\\\\\\\/ByqVBKUVCofAMhVdaFT4E3vKiUnz417kBxarFVLkXmKZ0guXYwr4tL9SF6TFUrrar7Uw+lERwCRgmsQkDhadPdkdamVr3S5VYPlzCIzJ7nLNHbsZg+TKAOfYEzroVgpFvm9dBgUnHdxFFMd6C0DkkKLHrme6oanYvF+A1bHQ3aIAXWupyJ+gRjk9jPMPPTURv4u5+SjbwnTucAQIP\\\\\\\\\\\\\\\/Eb19VCzg1Hlf9Kl7\\\\\\\\\\\\\\\/k\\\\\\\\\\\\\\\/Q+OxauRJGxMK5G9ieLFmLsfWmrvQL8uNHCDLJB7bccM4Z1nfMSrJkkjEm1rd1M7nDsO8e9zeyj0NTbHZDUxfkgfkLJjTSN61GmJIcTzVFBpsYEDCXywcmEFKcILwWSKl+UWf3F5lw7YIirVzEUrmFeB0uPFQA3HCIoxzChSv7Y2Sjk5\\\\\\\\\\\\\\\/4FwAhUqSNeBf4Nf\\\\\\\\\\\\\\\/S6nbSUmNRcWp94cQWsNvSORhU4780xO4\\\\\\\\\\\\\\\/iNVLSuyGSnwcOk93g7Bi0rQuCX4w40bIuuzq\\\\\\\\\\\\\\\/n6gEgPIb9uRQPbGN11OgqAxWvgX8RV2es6vRWixeuJnQUcucgA5nPdPVnbDCPX9XSM59B0BDo9ID8xoZCZtKZNsPK69G8cPE4rVZNoIiFGNZ8mY7W05uxfG3+e5VrMtVHYfzXOS9vrPMc2lgwjnjAVe\\\\\\\\\\\\\\\/r9t+RBRWBpKOXrmrI7b9mQ+wsWiko1bv5od\\\\\\\\\\\\\\\/BUmqb9JHBsYKqWG4aGTxqfl5xg4Y9NPK\\\\\\\\\\\\\\\/vvkW\\\\\\\\\\\\\\\/Lnh82gaO3lH7BcMSvMKBnFORiDAvVGm9e7Lr6A+QvyhHc43cOSH+nGnHqNDNtaVWtCExdyFPch3sSqqsRlZourHilFsJdw\\\\\\\\\\\\\\\/rC2EJ7ELFJomdZzeYxBaf8ib5Byuw2La5F7bdBdVAyFpgEF1riUgppTMGuMmaPta3WTMBzla9FWEHGD\\\\\\\\\\\\\\\/ZcenS\\\\\\\\\\\\\\\/K6qNTo6BsizqwBkSAYaYIpzpu9n6+Xpngcdm12943s7U1MJG3aOI5qZI15yzDX073IxzKn9Y0lx+iF\\\\\\\\\\\\\\\/McZJ4dupuEVPFQh4vCLQnnb0UTjrIzgm7anrOy+b3A9p9nlVdRP6\\\\\\\\\\\\\\\/l5ZgEWrCNkNJXcRnCaH9GKykj1RuQnOhQfPClLkZITXdjFI0odIqv5GpsXTiVOB\\\\\\\\\\\\\\\/XJhnRvYPIYm4c4+7Y0Ddp51L7JbPybe5iOisOtKtljIN38WwWSQMJH3vU7Mo8eboc6Xy01oMQnic\\\\\\\\\\\\\\\/iT+Lr5vzYzHVH6bH+5VvCDH\\\\\\\\\\\\\\\/vdU+sElU\\\\\\\\\\\\\\\/9fHAmFl4R5uum48u+\\\\\\\\\\\\\\\/8hY2zQMQzOLTQfM+qX2as7SHSEFNglUOefzi6LRUxnK45zxyeuHpQD4lNupfK0Wqv\\\\\\\\\\\\\\\/mtzZN9C4Oo8SCQW\\\\\\\\\\\\\\\/xd27gmw1yZtETpeddw0aQrYVguvExo4KFPN73riYmSAqrUpphfDwI7rUPIjFeOxJ53Gun9hr1YTob1v02XpgYKR\\\\\\\\\\\\\\\/s4++OceyBCbFXdEFqjW4iBs30cIIsnwU\\\\\\\\\\\\\\\/2nbIDXK0+IfOK50hRpkKZh99UwNruhuocUbep3fmhqq\\\\\\\\\\\\\\\/r+PWKj37BR6LSLaTUzfZfqn1o9wxS+ua6ZvmMiOZN9EnVF7pwU34S0Inc8R7Cx1bzrWWCjZWaAB5GGP3S72kx6tsHYdtjoDSlqIB6LLMug3TDnbT63ewu1oMiUTv5eOg9sThLRTe83oXAU4YlhgeBac7QvAM7Szjc4oxdEg4i\\\\\\\\\\\\\\\/m\\\\\\\\\\\\\\\/uTbyKd6EXbzhS3f98mrddy9KmjjcqqinedDYbxdijduCffSVvAusA0h5epb4Xchwjw01npWAsXHpE5+n5We4x+Z76Xx0Sa1jMHYJTiC18XVMseJ1w+zw6CFvMP2my6KtGOzQlB\\\\\\\\\\\\\\\/lWlsZcR2IEHnLZyrjLa5GFxDtRLOVgtnuob14E0QyN+RxgjEcLr6VfsJePLFC9nW\\\\\\\\\\\\\\\/eMVWlCsiN6+rt9MgfxY5FKTwCYktrLwgnZ14ij3eN\\\\\\\\\\\\\\\/ZR8oVgVnugJ5R3HNuaZ5X88vqrDazJTQ1VPkBQFdD1VBE+oFDPIQsibsOeMNypZJsgYB14ZrBP9ByGdl6JxvekS9t1LGo\\\\\\\\\\\\\\\/3oP1gJpc5wWFEwtY3Vls+O05BUyvUSL9rQhIXzFlkYJ2GSyAYYkUGZbKJmC3PysMp+xOu\\\\\\\\\\\\\\\/qjF0VYhK874MMNyeHFR6DL9JbJnbUk6vrwSjI+yzVPccmwEvgzloXbt4DEjd4NKjqqZpNsS5KLJ4vpMO\\\\\\\\\\\\\\\/Hx3G30OwAIVz6lnwofCgG6Kwz7gioEJvO9QHNwovDjdjVw53a6ngh3gxwRVj640k6JtJ\\\\\\\\\\\\\\\/66j\\\\\\\\\\\\\\\/idAq4lSoClLFII14AysgmIfCQa+uN9+UOFRE8Vr3MT48CNV2mjf\\\\\\\\\\\\\\\/0qDM88K2XZmj1o12SEqJ6rUcZKUmBR6x5+MvDWYdysTCo2jsG5ZM\\\\\\\\\\\\\\\/TNimbC4RGWdYQ0Ctq2Fab9xEx5+8mcnVwhFwa97JB0AnhsH60Umgz4Hh3TBcojm1veKuywKsDXZJm15QCcCzTwf2woIhgXAOkE3GDCTKPNE9H9Raou1L1LzjUj4mT7+HeE6rCEyzH+FCjYSZ7g8VjB9Q7myurdjAkJKZ1vK\\\\\\\\\\\\\\\/jnfPrZAlTW\\\\\\\\\\\\\\\/BS1xVKfXKbz362IZzyI=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022wyjv5xAuFufMTq9cbUIvag==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022145513553fed2c31b8e71c2b0665930e08b21bad4ad867f7ab17cc7a4fac7114\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/11\\\/e003318.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/11\\\/e003318.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003318\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003318\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003318\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}