{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ZDrpo6R9\\\\\\\\\\\\\\\/cy9lP7dMfV77IUwpqWAW5g96rUz1p11HyWIsNG38BzUtgxsVc7pufEeMx8O1VlcKNqSEWyCMoJTIo3Hp2muBDPnp3wlPVVfSf0PUjyjw28iYO7g1KVfndj1jLxNUz6MjkCaXlqs+Rk5am2+g5tSEYZPK4wCwogb8X4cZcGsCc1CGNoo3IzJIzDVeonpUvc25u1klfrR\\\\\\\\\\\\\\\/75zMFXwUCCr0G0VVyFV5EXcT5sTzhaSoWdP51TeUhUu8WgaROUc2qOtGriH1dE6Y3ts9xXr574xvFgaNy3QJBvC5B9zRJpViTwPZvjl8TT3YxKflAM72M4\\\\\\\\\\\\\\\/zkpsV5ZWxoRER8cW6xPWNnbJzO6lbq3t3Np2oNyg1eJ9qDvCpWD7LkZqJB4a8W5nlHTxNHATOr9EgG+dLAeC0Bw8kOwuuGbeXYpv1E+gbfCDVO1X5a9c7LEEI8IZiBgkRl1JdIvta3X+x9MUmPzZOblwdFJMKaJ45s0ownONPOxRtkBxBB+3Hj34+FGVZu\\\\\\\\\\\\\\\/0KIdTiaNEcZ5Ub7h6Kz95mcmrIfeixXNUapVPVgKlpByBjHt6y2myCOiOahbTQP3Jc1d8X8u5b471Mfim\\\\\\\\\\\\\\\/tVNjbZNDLydg9T+NDRkOQmB1jAZRnI89tcJW85OWxyfLQjOaCGR3HcS8hVq1uHRXSxIBKLrVVaTlrfVKXlJcwsL\\\\\\\\\\\\\\\/hj6WYLIFmMJkOtikAroykXteovX6I+mmoTQ\\\\\\\\\\\\\\\/68P\\\\\\\\\\\\\\\/4RQJnf5bE2zOSOYTVYK3mN2DSFrFZBd6tZP3RMPi0Xd+pqRYyb9AAQUpHVKT61Gfz4lLwbhnhiQBDVs5aQ\\\\\\\\\\\\\\\/ZDT6x6Ry5PBIQm\\\\\\\\\\\\\\\/sds9Ewqt7TZMVehITSZApjtXdhJ05ubwc0Xrkr99s44OtpLZSZVSCwyUibsw3pXhFvDns7XK0MMPT4udEWgRA5ubfhB8MuI6gCUE4\\\\\\\\\\\\\\\/BCYPJ\\\\\\\\\\\\\\\/cWRNCcQWIp17EO\\\\\\\\\\\\\\\/KU79LUriQhWIxA3876dvQ1rfoqq9oO0ZYSL60vIferw2Gc+HA7pvXF2wCRh2wiMUBRxf5YgeqoQkGx\\\\\\\\\\\\\\\/zCtsbkjDESm8sPQ22b+JGlLhVSc44CVee1ftw5ypUPyf+gsQcxFPzDE5jTwtVGhq+krjRvnU6vwdrqHbJqopvhHt3sZh39CfxTVCneMxRBXljtNrPvdi212MviyVPz53pCEVMbSBG\\\\\\\\\\\\\\\/CjxAmwuJsVFhHSZMCK7QwZNhr4888WLMkaXRikcajqxxCbiwMqZhm7cWSm0qc+61E9Kc9Zl\\\\\\\\\\\\\\\/fI7ZCiTIaWdLsmr8JjZSLXlUX7YiU9FHp8fpbroakfnaMssf91ovG5jY\\\\\\\\\\\\\\\/eo0S1Dx79TOtW2EX0TXXGQ3pBAkR0uB0YPs+QyhpjsJWYIK7GiPZj1nrohjzc+UCOlJEjd9HGv8neXGxtNaHc+\\\\\\\\\\\\\\\/1e43cJ04JGqj+scgbHuNLPNzdqIVfvUjO0g3wk0ri9ux8iTpB8yZVIXsZDsCM7CRPT3T3kel9vyV5oJbrPx3VqVI5Ui3M+hjsfqH7\\\\\\\\\\\\\\\/NHecifBkUGD2BFFLnXGdZFHECb20KpB71ihtRP+zk07EJM5Pzpo6wVimvqd+MVGgQOVglmXo0FAox5QnxnnWe42Xn+R\\\\\\\\\\\\\\\/ItqSY\\\\\\\\\\\\\\\/uNfs8x8Q0jwxUXgHVDHNHnjzfH+B0SIosjEfJO8D3UMzZVo6ZYVNMqEAZjKXLuvyNjiXDKwbTuKJqIrW2kk8jxVE2tACj5VJQnQq69G6DTilq\\\\\\\\\\\\\\\/O3F988jwIgliWIPtiKh2QNvQPuoXa1Ihni4CITTiNMjJwzqc83lE59bB+0i6P+ClvVLKwq8fC\\\\\\\\\\\\\\\/LKKg7cE7Zo0L5jCunonOVKvxSauJoLUZ1vehkzGwocNke3TSle0kxuLqGSnrrHFFSOSqHIOWnDUQHuIEARQmLgxImiM70kVH\\\\\\\\\\\\\\\/+Nkpp87hqoDpaEXnnaAKt5hwB7O9\\\\\\\\\\\\\\\/bmvoYCYJBk3t\\\\\\\\\\\\\\\/lqGlmTZ+aJZSgWS1vReyHfcs7u884ZAZiaPYBB1khrK3TeOmz+zhE1DZAMXxD4YJ2e1YPF4TDdadAZxjNJBLRYmEwCATfdBQeROk\\\\\\\\\\\\\\\/MYYrn6olFR5L\\\\\\\\\\\\\\\/n1NtC7nLwr7D826rZI5ZiO3vv7a2g2tO6yRtyIEpgkUk4iQzLqSAzdjiOs6rcZJJ0hO3lwDajivKshVUah6CQtH14dF24T8vCdLlfB88\\\\\\\\\\\\\\\/q\\\\\\\\\\\\\\\/Stq5oh8cNAwRkB1MKoATqcQb5vv5uJZ1av4MeCfFXhAjJiYqEKLL03NfpN+c9nkE9oOQyhxl4oxEolIijcsydBpy7Ddc5w4IPkKMQyJRYG8ew7Ntio97H9IvI5GaaumHcMI4UQ9SWmzA+xLwVTY+33iokTK8NXbf6smig3gCN\\\\\\\\\\\\\\\/AzkSdUNWHA547Makykgt\\\\\\\\\\\\\\\/5jzMc\\\\\\\\\\\\\\\/YgsKnFIFyz0HYyp\\\\\\\\\\\\\\\/JWPFwlMQFvR+gm4MxxoXKzUR33gQVpMDBxaAhFUJFoubBRDW4IaMzdoL97\\\\\\\\\\\\\\\/id\\\\\\\\\\\\\\\/8imtThHD4EO7wh3sTOBuyaRA\\\\\\\\\\\\\\\/mU8uUx80cQflzC3B8IitGzqr04wY\\\\\\\\\\\\\\\/Kl1oOS37b1g0eRQraGEYpKJveuRI5gTvyS8NhovepXaPsih4kNx2JqSOC5rmjGwRaUgrmcv1hdWT5d8yLpEGa5rgn5PRXF74R3YDGaDmSBVEGvPiiqnEYaVFHl2bYY5BZh9szUglkCk4ck\\\\\\\\\\\\\\\/DTEU=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022hfCtS0JYOufJVD+FLtwaiA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002254aab8e04cf3f01e0a3f6df8b6ea7ff97d544c3d7971204499157bac188555ee\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/11\\\/e003195.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/11\\\/e003195.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003195\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003195\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003195\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}