{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022JN\\\\\\\\\\\\\\\/ZWkcMxwJWvxW7L1fo7COdCoX2ThHPbKcBgo2ZPm+4rGgTIyHRl5IWrQYgz3Wa230EjuuswdlBkaKmrEjQni4A\\\\\\\\\\\\\\\/TZsujZESpSEZkxEvPDlJiXqXXNm1Mz9QUy07laHQn0eQteuRKQh79iSRICY0rN2jxUuwR+mHdt2q0m0pCKiICNeXQX9ljDfeX1UpeJqLxWrjvxlj8aOHNFajO5wZm87r52SVIUmyOOdAQUmUix928X0ZcR22W7lv2JDhADxrb\\\\\\\\\\\\\\\/x3khe4DXlEVMRZ354Y0hm9S2lupYw8z8VAaqTqOHKkHUHtaJlbO\\\\\\\\\\\\\\\/L2WNVqcfyzjT6jaaXikGChTzqT2CLtKSJ7iKiBJ8atuPceF3luju7GlcUciOBWONwh624mQU9rmUIAmDX215eMG8vVou0OgfDOlTOfJ8yJsUStoMvKTwseaWJjN2qoQQ6ulfnZtbUHXZQ2T6KuNxCxx9JrjbWH37fOaJlyNqB6Lbxjxm\\\\\\\\\\\\\\\/SlYdE8VW6tq+88QJosLrRxZXbrOisybI7XXA1LyObiJ6\\\\\\\\\\\\\\\/QRirh31Oe7I+Q+vB+NyQjsp2Dlr9q5ammsg9jbu6GdtvOMqhXtJNvVV3JFfSzqxCEpBObvQ\\\\\\\\\\\\\\\/Z97zHplyxhOCzySguQH0AKhUG5yzQHtd5vSB5YdiScmZgkV9A2sof2XXFqqem8BDubg5wg8Ueat5sK3tSXaeH3l2DTYzg4io1+WKwN7oG\\\\\\\\\\\\\\\/d4KQicZXxjwHOAzglBvx3Rw5nMvQNPHp+zDTNowrLqe8TLo4p8SlbC79X6DrdttQmY2ShUtOUeSuH9Wk0Tpuw8ZEZmeeWvM+LbzvC1gKlg3vTakI\\\\\\\\\\\\\\\/cbItVnJuWABr9XuUpDZ31uGpdgmvrIPChX2s6kkgln0FGv1eFWZ2by8WOuheYoGR0pNgCK9J9JSIhrvZ\\\\\\\\\\\\\\\/sybw8QCAHkqmOVMtJs1o0LFQDss3qmx8Hd0GEvdYrDsh0qp\\\\\\\\\\\\\\\/xA1L5KtEqAwCDS6rTxMbIaceN0E3AmzN2W5K8kf3vAhUwMIRyDJUwO0rp4sAYvYyW1caSqjKLWp3Uht5VRPIpRnnOTIvWWCceye7zv6dQsAnx7GjK2F3Uh7dJ\\\\\\\\\\\\\\\/XbuOVWiHSzpDSa3lG4LMAvUBDAPmVEMLIOO8Ivqe7O9+C6hQYt8ouQs4Lg9PExj4GAujKxWVdmgsQQxeFjjossDyDotPjWRRolDyQlS8a8Wku4HDR\\\\\\\\\\\\\\\/w7eeRV7isLc+RPgB0BbcXCae9SixJzSHMh0VwAlogpsratU0Qs0yF\\\\\\\\\\\\\\\/1cJeM6cxig4rvv0vOy3CiFs8eFfEpMq3oc+NwovLFvn8S0hpDnQ6THYy2SmtHRG94YXynIg6LVauS07tB7pPWUfqzIELl02o9HyxWr06xQlDoYmE5BSjvplPXtvKIX+C5ECMkkpUzI1UfpIfIeDBdNccDiw82ronbm4O2GJhxxO8d2wz0xtCndVzE1u+qeXYJwqXHnyWDwd7TJj6xP6RpA28mRd1NA8Q7X+B3ReppjnY2NZ1nExiCM\\\\\\\\\\\\\\\/2ollBye1Uzs9DHcEjDS76R5fjfNE7vOtlFVeoMmQFBIxU5cTpjTf521LlBvkneERe4dG1FsdIbjFP7QRGao3m5dMJjotPWwFb\\\\\\\\\\\\\\\/Q1OOvOiGBDK6hlVqZ6HkEfHRVljF1fjQXDgVdC5dHh+\\\\\\\\\\\\\\\/dnaRkOfC\\\\\\\\\\\\\\\/GaQpBLct+XiWeopgkgji63p96kS72J1bimRM9jscXk2caEaG4TaDkEzGHNOQqkkMwu62uzaMFl2QzOj25wAK7J41a22N7PIa6JlB+xcL7WLLrN3qudkjpQRCcZ2Ck6NYfrhBporItEInMIprDOWu+3pN7E\\\\\\\\\\\\\\\/eGk8hIi0reSZYUAsobuY1euh4eyBT7Zk9M1HsZxijfqN3tBmllP7NSRATfMlx3l6zkPPwOkRYAemZf97XnqoQrXPtqeOdGGPnUAWpoM4HJm5kjTTT56mb1i+bJynorLCded9IiVzxbyPRieYnlhkD05wt2ZKfwIr8gpoIKneVYiwXVmEG84\\\\\\\\\\\\\\\/vq0pRM+91jdOFeq9h3szAynj+REtFbKmBVE4JTjxR5hrIQ757ttmK3Gk31ULhtpHfJdex4GXDsXbkg\\\\\\\\\\\\\\\/jNruY\\\\\\\\\\\\\\\/6+fAimbGehIu7KVFV6jAYZiAZ7CPD1AaHzeraCmAr6WvlE1mL59cPGfHn\\\\\\\\\\\\\\\/+h\\\\\\\\\\\\\\\/n+guA6\\\\\\\\\\\\\\\/BO2p5f5muACbCd+UvfCBJH6IGaliKu83Wi71PwcfBwlVc+qqPHZLxjSU\\\\\\\\\\\\\\\/BwUDArCngcj48i\\\\\\\\\\\\\\\/VHGDfP\\\\\\\\\\\\\\\/yM\\\\\\\\\\\\\\\/PrfTWqBBvLd8BBaG2A4LILqqtC++lHH8RNjYg+OR7VX7LO\\\\\\\\\\\\\\\/PDcNs8qFGqMTydaWmB+sFANoNTH\\\\\\\\\\\\\\\/noIl5fpZplHlxh5J0X0wiV3n42ZcS8SpzNzxnea8F2BDXUG4\\\\\\\\\\\\\\\/CQRFFPsofVu9osVmqg11GWvh2yecg649+XmFDoMk4doldTou5UIhb8DolaJVghkpf5B+FNr3VkRao130QdsLjJ31WCRv0fQcQK3HvRcigcZW6VEUchCZ8ij+dcgpgTu+59v\\\\\\\\\\\\\\\/8V9EX8+Bbix0V587MX1Wbb+qvgU2l7O95M\\\\\\\\\\\\\\\/jfLcwGzQkBPHPDfxXb4VsdrieDOLkpRvmf9Lyxzov9sGbtc7rm\\\\\\\\\\\\\\\/bq7I\\\\\\\\\\\\\\\/WLoj4FuGTWJYbLB4pyCJwmF9PEuMzLM71RgCG3\\\\\\\\\\\\\\\/+KRN88=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022v0bf45riRhBNt99Ka53oPw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022105d9445daecb59396ed86240968306bbe7209d1670be26335d6024ad2b77b7c\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/11\\\/e003254.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/11\\\/e003254.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003254\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003254\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003254\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}