{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u00224XRH1zOFqGQoBsYS+ipc7VNrU7vMtjXxiD1yxy0GWjNblcVljrcf2l9oB7h5s4nVqJuc\\\\\\\\\\\\\\\/OOYlAeM8YncPXLKxvO0eABNxIIXbQqxOl+VWS4qIb0iQlxJQekTVUqBeO3Uplbhu2rsAN5x5bek4pyiaj6TEOjTlat4wHhC99XI26AeubOYMUlcSt1vYg2QbNU6w6f6rflqLo8IoHMoPmpnhjfoN7d52SYXv60rs4NFQj37BVA58zB90+9EbUeVZdb5eBnVNUKIn2uwsHVHUJmfTM5NnyOM4ctgITBKShkIlBui0t8Rff5kteZ9SQY9N3fShy8qu6l1unZiRloIqI4KdUJbNWcruIBtSR9ID70\\\\\\\\\\\\\\\/yHK6wfQjWyPDj0mFZeN9VWAKCcWSgHzCTpPvqLgaHLX7ZS1FCpwyDD8P5bTjgOleK4o6p0V2hYjnGhMy45Z9aNO5ZjHExZU4TN8Hmu\\\\\\\\\\\\\\\/UgYAdKgvz2o3RGqxdRl7Nh2p\\\\\\\\\\\\\\\/Af6Fo\\\\\\\\\\\\\\\/doNqRLAOHP\\\\\\\\\\\\\\\/C5Dz+FH8v6Ewlk4\\\\\\\\\\\\\\\/HYLb1RzFKwpBWAeWrEcUlHu7Q8Et9nxzL4tAd22ikm4yM61knP4nFlR6xJ\\\\\\\\\\\\\\\/8ABnK3krwaFwUen9uFufFHDC\\\\\\\\\\\\\\\/iK8miiCH4oganhHuYc0BoJO72wOoEiNjhZQnOQOwk78xtflVLHeixQRnR9Of2WloUkLiSA4i0hEiw05ITVWojtjvGZGo4\\\\\\\\\\\\\\\/9HjZPnBoKJBNSuDZEJKKVq3ZlYhK32yf+58XAxvcBysraXuMT2E0gFpLfFFXGDUg8UVgHKHaMKMlmT2VdcFh9M8fA0HNtqThj9mHvw0PUF0euK7BD63RFrx4rM7BEOky1qvb13ExtxmTLVJGr6Ba\\\\\\\\\\\\\\\/kh0ks6eT8OhGpRhf6xDeksS3GA\\\\\\\\\\\\\\\/BOudyD3Cm3NGAQpIfnuyvB3bB9ymg5LeQGficPbE1g6pWagO8F1dQABFV3IfJHQtM7lsQM8tADCgDlx0aV5uaC0zk1Dz+DwiKyrEp+p2R\\\\\\\\\\\\\\\/1VuHPez72swtxChpN2oMXMFa0NahLsYSzGFd9TV2+sGFYZKlq5CCg8JZEO1ryJqOKATFzLqoEL9RUBaElvbrwnhKekHy0vTMyumlZtXSKXaAxRaKrxfzojQYm9UlvU5aqg\\\\\\\\\\\\\\\/LfeWWZ0mmxlJ3zTsSpGYRudC8Xy3NW7iXth+jO8XK5r7PuLjLsFZtrmVdGp6t40ykHTi+unUKq5PbvUJc42R9yD+Ey570M68VIzTc3f\\\\\\\\\\\\\\\/9ZFkU+WxafIXAxuWl+2f90F1hP9njgbW6PcdFUPDJtIrOCByUKQnWyDZrgBPr4DPwRrqdvPwSnVNMxZsAmVml2ydtFyYEBI\\\\\\\\\\\\\\\/A5mlsu1zgmAjgKKgzNcMgBCzkn\\\\\\\\\\\\\\\/88VQIbPlPVt6mrfn7RCMovo2vvL0BgLMriSehmconsMcf5GscsmT7SV5YLlZzTs5iZ3P47PRIY90qWFVh7KFr6TybQHz8EZor7szrkR7luP33qjqQn5cTH0kl9sFdpXU026B3KZad5cslL5KsnEaJeKgfGE6HTcJMhNv9gWQE27S3eADh1Io7tgvxu7+Nqpee4Q9e9rezrEcdyW8uhiLg4IyqEcMB4EUYzdOGoku7vj67MB3l6B\\\\\\\\\\\\\\\/Adnzy5U9\\\\\\\\\\\\\\\/SeAecSTeY6SmAAc0JZ6DVdANzwMszGLa6unXzunP\\\\\\\\\\\\\\\/ftyhHxikA9odQBoC900NeKoLEsSH44Fgylu9dpFiG40Evh1VhfIna8MpfwvAIfoJRkqfwP9YCSvY1SMs\\\\\\\\\\\\\\\/lqUoZriBmDTAA2TNCY6y2RbPc1PCQwXtcSjVzDYYtN5RD64r+VI3gjar7Rv6hN+dzo2R1lD0+3j3EK4QdAYCV\\\\\\\\\\\\\\\/Rvs1BTIXyjdBmuEb1LCawyVG5K6G6T\\\\\\\\\\\\\\\/FhBolL3JGjrRFTpP87rcpbkkvbscMPAnwVw5Cukg14P+JE71A8LichqLt\\\\\\\\\\\\\\\/eATjj+tza7jQGxi2PqX5y7kvLjWKEBofVs3VvFqdJ6rU0fBWSxbSpbqf2XH1DpFTX1DaTdAhWqJp+Guz8yflqwF4RNfzxDGhYa94mmDoAqMjMz9odGw7jbvsmwB\\\\\\\\\\\\\\\/Wr3lmirb+UrEXIF4NVR+8AgvA4QOjXORs+7NqKRBjobM7BsbCNilxVexhv8MBfuOFrJ50LPC7cH38rqZtEGrNCwgPSh3Hnimead3KmKJgAiCQVka\\\\\\\\\\\\\\\/We2kN\\\\\\\\\\\\\\\/ox492X4\\\\\\\\\\\\\\\/LthfO23yK\\\\\\\\\\\\\\\/qHlmPtR63mVwfJXpL2SfcBHT0uB\\\\\\\\\\\\\\\/r8WJAMJWHTS5seQ52vXuy8YJWHzqU6IBxpYjBkax75Tb52g\\\\\\\\\\\\\\\/yvLlHmAj73WL4JFsKpdW77DmijS\\\\\\\\\\\\\\\/ImLm4fJdPOdJJidGAkieNDgLSvmmi5cDksV2DJI97VWtPl\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/SFAgOrfXHTmaA8o30gaiX\\\\\\\\\\\\\\\/sNGae1Rc4fKOSy5ewFVD7YCR+msYlx0CjjXQQnm526hS+rB\\\\\\\\\\\\\\\/BxTfBMyhLoSNI9CSHytxSB2iCAXSEPB7sHMwQjuy+1ygRWWwwVKsMehjIBIlMeneH6rKt7Px2fmEVN3+EFNt1xCRxLeOhNhSe3hj02x7RRZHFS3J\\\\\\\\\\\\\\\/JL1i7mZg3Egitm6OsjEiObkunBErg9BIsN2i6qOApMZSP0DMi45lmO09P6klahiXzMhpxwdHFHLG0RlBWsplTEqiPLbifP\\\\\\\\\\\\\\\/nFxnMz2FLo0FkaFBl9fqiYM=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00226YAKkibvejMDjp5IhsPGqg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002217ab430e6ea0293cc4cb67dad78f986e3be52002d1cd538c11d6db69f5234d80\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e003109.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e003109.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003109\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003109\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003109\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}