{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022qIO2QzqXgwQwih4wo4gNeOtl60oM\\\\\\\\\\\\\\\/gHZjqra19chs7CwoPG84M+qlE\\\\\\\\\\\\\\\/afpeKLOlYy8YeO6nAiLHu3dsueQ20F\\\\\\\\\\\\\\\/Y6Tyl4kj3ZBRdIrQtSQJDafV7\\\\\\\\\\\\\\\/tVrxSns1X7cyUwPL0h+OFG7O8NMZRDBqHDYhEy\\\\\\\\\\\\\\\/rB\\\\\\\\\\\\\\\/OmRRbbxym2vLIV0iMZgXSlTq4HgaP9A8x5JY6kQ1IKB30qCSkP2PB4cCr19PxCP80BnNAocKV\\\\\\\\\\\\\\\/BtD3rcuzOGAvgDJFk9sZ3kCagjS\\\\\\\\\\\\\\\/PKnrmGW+Z\\\\\\\\\\\\\\\/i+4O9F7\\\\\\\\\\\\\\\/BGQQ4K0yj1Z1DiXRlAU6y0XyeQKqtZAmyhFEdRp5\\\\\\\\\\\\\\\/exODcGPExEVm7syPpGQaF0ES7AZIH9+dV+HfgrxdMBQonMHPQWINEA8HXV\\\\\\\\\\\\\\\/XKN6O5DWZTiTP+vSlpUxk6u2RU0cLeG943UEUFl7nN5+nUM505KSmO6JFIMqNkAgHG++Oj0Nv8V9kOPZ7\\\\\\\\\\\\\\\/q7ldr+n9yFWnN2V4dbkTRrRidzyQ6aAXBx38XxxFcFH+xyfEhIpjOsGFFgqS6EdXK9KDvIVsqYlcFmntbdS2olFOB1nEZl1Ld+q1Klf5G58VI+vhs8tVKxX6jqGUgv8SyYx211BX2BXRMUeF2ZKVuCrFuahaoFqTN7UdNfxpBH9s\\\\\\\\\\\\\\\/HO2pOTY6D3A7snamnnP3JsTIDcj0sLYvCcTXUGNKz0yHuUCZEAuIfkyz\\\\\\\\\\\\\\\/gwZH3ekAlHhyRqIpdqXlUxdFa5MxAJmkjRlxV6HNHuvvJsY\\\\\\\\\\\\\\\/Kzok+LrgWTbRH6AipCQKlve6D\\\\\\\\\\\\\\\/VIsbUESBx5c+xtf19t+yHpvOYfwAtoA83TtVWUeU+yF+gvGy+v5TMpy9OaM5ANz83JJGnbQct+T5J9zO5iWaE0oDQjRmv3t3kQHBeJTbueBp9Eh4RklRRugn9+3lxPg86I7l7tJXE6VPPOCJI7wJk\\\\\\\\\\\\\\\/lm7NL0g3CFpf\\\\\\\\\\\\\\\/U5ED94U0Ro1jr7XzgM2lLVRHlPOq14NFtx2bWwXxURuaS1nJ7cjYEbIpj+CxgA3n9SRxnub2zHZBOM75sxJLfDnt3APJRbjhVjENuRevpeS3S68MxqiDYq3AK+iEv4apqhMLfLR3Bg3tz5Aql7jabw0UTIhCm\\\\\\\\\\\\\\\/v\\\\\\\\\\\\\\\/HrvmYWU1UZOK5Lo8mvadwXJsnYfQyuIbUCiLrOysuhUsXBZrkPTAMTc07bht3td3l8eU86ZFdQdzfow6ycezbuwPewMre18IQNiaoq3Xub1wEb\\\\\\\\\\\\\\\/BUj\\\\\\\\\\\\\\\/Vn1lINXBsBMGX6fp1yqjp32lLyyuces4Z1BM18akPwcu1lc1K+v\\\\\\\\\\\\\\\/+gD\\\\\\\\\\\\\\\/jUpPOEMU17GFxiSeBaSy5qpMJnDQJFnjfIEEbtmAh42fITvnDSg7RWH9g1WQQWKDwm2eutupym7XfGk4yt\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/28AOLIStZ9t4qghZT+m46FS5w4U3qt67eYzMqGL9AxQ0s8pLtM91T3UzYEbbPrYOGALOAslXCr9W7Uck13obL7yrN2EEaTpc4Gk83c9vQYkLc\\\\\\\\\\\\\\\/iFmOZF4+1lS\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/oyPqS9kq7wccDuPC5Z5EyKCSweNPlj6\\\\\\\\\\\\\\\/YTRWQ\\\\\\\\\\\\\\\/JOE8qhwLfNNhXuMbKuY8Y8Fdv0G94O7YRT0EuXwwtSs4Q2LrnwQcdWCi+INCcp1pBVlDquiDhYkp822l4lTZZHkRwyGumfyw4CNhHLGNqhyUgT96njZ4f5SO\\\\\\\\\\\\\\\/rP9OFYvQI3AjQ0BiozOAyRbp2lqkrvmo1GyisFA4OmB5vmhFcwT0s6WJspKBDtHeQrzXbteUjr7msgk8Vef1b2EfQM2psVSCh+8ZCL62mXO0c8WJ5Gtu7NSqJtRv1edDPq+1kZF06GZKPjQrodQnQtrJnv58wPr8oRQZEyw1aMhJm74huTtEanQzPZq1Aj4Oo5Glce+BoU\\\\\\\\\\\\\\\/2pnoZ7wms9Auix1r83LRZBCxvRVfhFXzza7Up9ccaMLoOADEkmQlYwZV38VwqwA3N3I48o27ZRJgH6kKO\\\\\\\\\\\\\\\/oPSpB9Yh2Cw0Z84UDOK7mRNwAEe9nS8jzxyNTNLzx7I3E8ANfXiNxqZMnkYSh64vsy9VcDuuteS5VQyBXYlO+91jwclbzlPzScP4a5HOAuQ4RvbWJ7+EpwJJ4ZGF2V+1fD39AFNUPOZfBcCmY0E9+TBlU3vwiyN1bb2qY+YLn+vn0qpctWTeJLpkM6i0+hTPo4VUnpFTNYnLnICRJfg8nXjcJ8cndPnWM+\\\\\\\\\\\\\\\/fwnJBzZedogZWcfXnLRXin1KrsIhZwC1CH3tRMFwSu8v8R\\\\\\\\\\\\\\\/4ztyUtCcwXLldUgSntLDH9HTzRBUIRf2T8BdJhJgk8+VeHxsFFaWtgDkXxnuXKleQ1RxV0flMUB\\\\\\\\\\\\\\\/tQW0Ht9tzftc1TdwWWQdEUWwqM8YEXpv\\\\\\\\\\\\\\\/fdiMajPTDhaVxQaTIxEceN\\\\\\\\\\\\\\\/y2L20c+ONBa6EWoA\\\\\\\\\\\\\\\/PEcQz6AwqotCPPy7xHIiy7N\\\\\\\\\\\\\\\/9iN4e1GmzVoVQZPiD36rIrSd1Yqng7Ykog4Pj4TUJroyWvBsLFWug59R12LrB7wEy26uUa0bimlbzddrJvbX9kvTfkUm79P67qxy+UOmD3j6IZ\\\\\\\\\\\\\\\/aw95Qe5j3C2WsWytttwNu8ZbEr4wmVwJZSxqhc0C7fykyOwrtMF3I9ijt\\\\\\\\\\\\\\\/GFCibbVYvFW3nRlwhILwURhpDqSyJC3hSnuo9Tt\\\\\\\\\\\\\\\/Uv6bViM7FTA4V9Jylpbaye9aedosDBWDjGhY5wLHDs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XI1DAyJhg6qlwUnLpdv3Gw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022fbd8562a539116f8e1475026bbe0d7b1170e1039e8a6f6cd50223b8f0b860842\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e003395.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e003395.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003395\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003395\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003395\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}