{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022YNPtnaMlMFgKsenEWmHR2n8xawuqZrBfdfJxVbNGtcCbRPI\\\\\\\\\\\\\\\/NiXMaJA5moNA0maJxMCi\\\\\\\\\\\\\\\/oxqpCxxiyf2MpuxbXqeCEDH+Sg7rKl0iMav9TDQcKwgp\\\\\\\\\\\\\\\/fUP3vh9z5eK2UgsGXxuzUGM\\\\\\\\\\\\\\\/UYxlUMd39NsXlHh4YqEstcz8gDpf7dfnwQSuNhmKl2NJ0FSmr6N3VHs7Ji72gsOsJXGIz212QBCTzy6oap6dWpBCa0KbTSgxqjJL23t\\\\\\\\\\\\\\\/UtNgpRn3YAwaClPHFzLVD6gMjqo97z4qa++jc0TYKmYztc712hdfe8LZaeIKY+bVq2P3mA2XBIKt7OvmqKm6pEoNuy9EZ41Bnsz1PJOx4CGMXch9TibTwHFfzMpnR9McE7EQcXCLrYytSu5uDaS+6gJNycbNBR1NiCqi9RxcVJ2QynI\\\\\\\\\\\\\\\/sfwXkiDtIpBOc7yAZ1sQNB1STajK8ZqoAf\\\\\\\\\\\\\\\/Szq25DaUU\\\\\\\\\\\\\\\/2U8wgUefiqufd3FpJgqEgXNdMbogPCCtT7AMT1kLdsUUTNmvUrXamCLz7imx8EjY4TH1mt5VBodMCC30tr7brw+TUs90HET4ZYgEQwRiPAWj61qUpoPJGGsFSTaZGhpMKvEi8wSTR3NSLgy\\\\\\\\\\\\\\\/aqmfA6yq0GW6yM9Rmo1yue8CSrYwN4fhKRAt1KJrEjW\\\\\\\\\\\\\\\/O\\\\\\\\\\\\\\\/EW6LsgZfBvLaa52vhak9Zc0LjwgYDMo3X4hiR+jKXsUtFmKqDH96F0eDMtrCt4Qt4iPl3XnQH2eoTUL6jj\\\\\\\\\\\\\\\/pXChvYGuhem6sT2qSjaXOZCgsvWd52OgkBeRDH52ewdaztw4jpX+eFMJwsQ38Rq+9v3USQZ9OPJpTVB74vsZyLBGHbRduprZ2hiiNIFmFjPumQCmfYzNZW\\\\\\\\\\\\\\\/qsJq0fLJW\\\\\\\\\\\\\\\/H+H9z\\\\\\\\\\\\\\\/Jwo+Xx7wd1osvNCS7+S+NhENGCnen9v3GkDu4\\\\\\\\\\\\\\\/HdEzjPpmmDCbZDEqr9EsY\\\\\\\\\\\\\\\/PD+aZokO8WO9I6LgcMwDUUxcm1VfWMJSIn8NR2qLQqVJOYKBudffNMMY4GQNpVgt1DSroIiug7b6YQlL9nHfpGmVo2zTZDo46lJNyaNUIE33pplPNnGs+wNc2KkJ60+7+mlHOEqreUjAJ9j3kymyD\\\\\\\\\\\\\\\/VIHYKcY1xZQ4t2w0LVLKMTvJhJTGsRHru8r1csCDWPdkT2x41NPGrqHFSp3f9zK\\\\\\\\\\\\\\\/7bbN2C3CZGy8kQhipnIS2Xdef2w0FaOd25WKm8uT4twTrkl9Im3Hjj7jo41AKB7eWXYY5oe4hN+kHAePiq0EhvaZyXkuBkKvQjFFbDKpW0\\\\\\\\\\\\\\\/hmDy7fJZU4sgxLd+Cg\\\\\\\\\\\\\\\/cN6tg\\\\\\\\\\\\\\\/Qu+Y+9SmXMoxOjx0sEJUGWfBEEgdSwbsvPA8ZhcyVb2awDyctq5r3XBgRG5dFEA4dJLGubczAfbdPJfqPLcwASlOJurES4gRxKsfcCGHEw2l4j4\\\\\\\\\\\\\\\/cpJm3ir74kczYJq\\\\\\\\\\\\\\\/Zh0QtmF+th8zxvr\\\\\\\\\\\\\\\/lR94vo5qwYJ9WkNvLnjP6LlgXcK\\\\\\\\\\\\\\\/jNfHOvjwMuV+MwRhBVaLq4tALuD\\\\\\\\\\\\\\\/119atES+ciWI9oFwqamQMDVw3Kxslh0\\\\\\\\\\\\\\\/kNAx8n+lVcdR0+1wNmNzbfGyd+2dXFbXk2G1DJGL\\\\\\\\\\\\\\\/0\\\\\\\\\\\\\\\/ecU4DPJsANXs4u2j0jveVtR6Eqcz4vAGDRFcxSbyY4jeQQEcMdgbd\\\\\\\\\\\\\\\/a9\\\\\\\\\\\\\\\/fueK+KrhcBp0dlpFjE73LiUpwiQXMoF3ztBe4iyM9NN3iekIH\\\\\\\\\\\\\\\/QefuqZ4qd5MBZhgCIBsq2YqFjhAtSurBWzrn5qyb1oI54eJyhoFpSue2s+CobwzIpWCPkvvu43WCYWjmfbqJqATIuhAjBWIgqPTA2xwYr9e83e\\\\\\\\\\\\\\\/FKzN1O0V1P8rRNd3Ma8MYg1vZIliBpFr00bNAL+qSvqSamaHAngg4VK92NzS5YzFYSmo2E3OukLK6p8P+k7egY6ecqUlGYzsy1hyKaEMWJ0vMBCbYbTSW3R+rVJrZ5hhzc\\\\\\\\\\\\\\\/OvtJLfIfnC1j94mpMHPuPyJqT0E\\\\\\\\\\\\\\\/3groGGuXeV7go9QMg5GewlpySLrCvwuQzhsMhVvO2L5B2sOInNBgqYNQCgA5x+GJvKwCzAqC4BQYVdUfyxH42KA2Ssy\\\\\\\\\\\\\\\/PboWm5CLnCvjry03PUVBuUslcSDGYDq\\\\\\\\\\\\\\\/IifdamQjhaYiANjpPNWTyNru\\\\\\\\\\\\\\\/ef\\\\\\\\\\\\\\\/86aJO5oslMWlpQSazlpmHCfa05DCWJ1nCPY2GzGoz3g0l\\\\\\\\\\\\\\\/QkGLXFuDCP3ROIZDNR9PnOinS3XHky9Ap\\\\\\\\\\\\\\\/8LmuPmCXYtUIF4Ik59WJ9\\\\\\\\\\\\\\\/FqJmKlrjXM8m7l1UMF+CYOEndF0sVp3y02iOQ\\\\\\\\\\\\\\\/oDK8LhalOtxm9YGW\\\\\\\\\\\\\\\/hWHtWMY9Q7VrD1FoAmQnMMfLbd7x5D5dv5iQ6cx5LVZ34oISaXFxLm7XgftcSR95YEXP0Mp2UPashWGvbV3fmwhJDrY1y0tjffLLcAd0Pov3kRPc95RejgoLtBg67H7avj+UUJa8BKbVWSA3LDjccnmVTRLFQzndWFJrg458oIHkEGuOfD+jhWz6Az4e6cWhCq6kb2qGRcKSNr9RcxzDcP+Od2PjwBxJW0IN0BLKp1iMPRyHHxju872b541zFovggjymwymNqZf437eNH6ksERJFC9ZUEiHQlTK496L9XvOuV98rebbS8XLDmkUgzob+mC64PyINSU9Wla9TI9kSsYpFNUwvT19ocatWaJCSRunCQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022QXGHy+Y4OHpOPYmXBBFDWA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022a491ce73be4f63a65cbfe5aca6de3a84829489d247767bcee66604051a44cd47\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e001932corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e001932corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;9\\\/10\\\/e001932corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001932corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001932corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001932corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}