{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022R4a2Q+EZgfMSkRidkdCoHWL9r\\\\\\\\\\\\\\\/rF5o5G8ElgB0kT4BvFQChHGunqyNLowFh\\\\\\\\\\\\\\\/ye56Tn\\\\\\\\\\\\\\\/y3xaLl9cfrd5A2OKrWDajG5lqKw5AQ5LMmQMyUmz5+D8wPHB2xOYpSn1N3gdLiVq1XhbXpKfxwBf\\\\\\\\\\\\\\\/X7DE+0sq5umKmV0tlN05QGMpJhFm2FDR9C+lxKeOurT2TNwt4m\\\\\\\\\\\\\\\/1Wln2qKeTJstR7wfxhByCbw9yOE\\\\\\\\\\\\\\\/XLagmM9PmI71JU0CSBA2gzKeRuhmqZDA7VzwDxcZlRWXnBE5+jyiMpv1Ljf7UOAl\\\\\\\\\\\\\\\/VGBSQ5P+\\\\\\\\\\\\\\\/WJRY4L8md+ntbm5WlDi6HMTEy8h1iVYdnRqZDGNwBvpNZd8Me5b5WQ2AklcBlh6aUxcQt56CJtsibEzg6U2p7\\\\\\\\\\\\\\\/un3bTlr5bEVZ1J0EgD+ifF3XmzVFQoArzej8WbeQ\\\\\\\\\\\\\\\/K\\\\\\\\\\\\\\\/TJYk+Y0GROZsnzTubH2B+ugcUszjVbYorMPNM1FJj+vmOuAK2nzzBzBdFVvikgF9u4ujwkXp57Yu6WtmM7V+gkNgnHK9AdM6gON1f0JzXm+DSWmaWGw2we0TFAtDdkSFPFsMX8vVky8jtGVww04NEDcyH9fxMIFnHLsIjwBTr+7M5pWjoc1O0HVSM9IlbE9W0UQOK6qxpltrwI35O+lEdrvHLdneooBb8M3QVzNydYqFqI7AvmoYR\\\\\\\\\\\\\\\/tL63QUmwCIM0WSz5aSQlhDdmLaRs\\\\\\\\\\\\\\\/gWCEFpwxTmANNZMnCToccrm103CHjHrHAOo72+QqfSY0G30LeUUveCRklb\\\\\\\\\\\\\\\/VlO74eFarKT1aW9Sn4zE\\\\\\\\\\\\\\\/7k9vL14PCB55Y27vrJmPsIihMYYHeggB7pRdM9o8R2bSkYMtCijo+aCA32VhYc85i2LHF7+2s9MOZIxAqPzISm6yrMJgoA+iO01XFfrJqdZDKj6d1iFuVSjN\\\\\\\\\\\\\\\/nLCYT8xFCHAGyNcyhNKA0VPDwHJ7jCk2m7RLfmueOI4jTjdROP5GYYbCY\\\\\\\\\\\\\\\/A1D9y+haSkDnQEV\\\\\\\\\\\\\\\/GIBKuxPDiM+64d3ybZCtnRdmc5HnvKDzJy4IWg2pTbdennRO42TQOT5x8q0QhbQBde6xNrGAJZK4V44prwEn0zCiReRRBmzsSsa1EZbDYQNg1kr83\\\\\\\\\\\\\\\/G9en\\\\\\\\\\\\\\\/iMJANDsMv9pEqpzCt1Su46GXlySk09SUiEVRa3nH8EUwt8TtYerY+\\\\\\\\\\\\\\\/2Ua\\\\\\\\\\\\\\\/GzAS8bE9L4ahyN\\\\\\\\\\\\\\\/lF0c7YFiwYoPRbhDJfRwB\\\\\\\\\\\\\\\/25DakaFJMbw4tuG7k\\\\\\\\\\\\\\\/E3S5zocBl609ZpnRLBkyDwkU4ckT+sDzhAiMOQ5a0Iq99liUTFcRI+cbVOnyZ0Dm6ZHw70qUzEz+GfRN3L0wm4c9OnSEcN9I4FhjWpCThcEhYksxrIBRxqFQeHQVTXiGAhFPbOJ3ZflsF3PxUA+RmycZ82V9txgiljWoewHajAZq+NZfEs9ZOyI6\\\\\\\\\\\\\\\/ybGqtB7\\\\\\\\\\\\\\\/B2Eq\\\\\\\\\\\\\\\/oTujx4Hr342wEVTu6+XanBYVrtoBHfrpNsF7vaMDBHxxjuMQRKni4fiaBuSho\\\\\\\\\\\\\\\/9DXzXqLcfeRX8YpfM6WdzZBFTe47aGU6+i8EoXZxRz\\\\\\\\\\\\\\\/Hy39p3N474M43DSe9p0PHXFIjZ0PccVFAWQSjvx3dkACn1zkQAzNGy5Stwl3jNyYt+gwGmUxh7XvbmSvAP2qTPZY9P4mfUVSqn\\\\\\\\\\\\\\\/FIA0D2Vbx8vJnUvBd\\\\\\\\\\\\\\\/xlvEdS63YitIO45aH2X9IQi3aCiGJzkCbagrzxcm3I0Ffk8OMh\\\\\\\\\\\\\\\/QBLG115Aw923EW5hHUi5qJVnRxrqluR0bf9uF9tvPEXvmeKkNVPk4Z6WZwI28CDeLpKN1BbliyAFlF20TqXHaZ9Arz8UMqsdqX8ircuvIlzWbwzE0KTY9oaF4y6WyHAZzWJ9Ie\\\\\\\\\\\\\\\/PEDcTG1dfQL5KpFS5bGJEiwBbnU5L2p1fsX2C6Me10yWOD5N4gc5wX\\\\\\\\\\\\\\\/CFNtgopmQMLqx2Q2H0CT5j7v7fZOMJSyN6KZKybOcT6UltJBKJEcvRr6mRgayjo8h1+mddFCwX4QmL2gZ0V4p3qV88Nso0pRs9TJxfVV97NSIJJxdA2FAh3BSlEMwNBTWIonqzykzDS20R59o9y5pvkE+m74y5+SIk2GNWepZ6KcbKJpaU9S89tKzlyL6Vy5aKh+Umwlgf4\\\\\\\\\\\\\\\/MgNCzIPOAqeqAtvpTRdcf7L8NEqNTKe7rdu025\\\\\\\\\\\\\\\/BMzygZ2+UUTtOLwgDFSHdHaU0VrMutm2NyatCJm\\\\\\\\\\\\\\\/POurKnwefMD6dxZL5qiIproyIUzIDOX5UsldiOWVMsp172tNBv6jsRZVwcRbYj\\\\\\\\\\\\\\\/ieYNYnAMnS\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/HfQjTU8DsHj8SRljdntOXQ8t41Ki3opLlD6fbLxD5ZrZR6RNWT1y3JxFjDfZ8JrKyLpSSCCU\\\\\\\\\\\\\\\/B9eUMu9y3Owc04CtgoFQgAtWr2mx+2Cm0dH+I+bJfKP0m\\\\\\\\\\\\\\\/kaFV7nUHwCg9w0aqPr9sOQYMfCozUjNahR9UkbzvdZl6p8o7E2QRI8u5q\\\\\\\\\\\\\\\/pH8bcBwf\\\\\\\\\\\\\\\/9KRotSEvfGffryeqfG2ZBkbPaSy2GlG37SpDt3r3L6nv9u\\\\\\\\\\\\\\\/XPb14PF75cyjljvs5G9Xhr2bG6rYmqtRVB54NoxxiG7M2qkHUlakHEj0hf3E9S9mOZtDBovJCUK0aNVxcIq1oeHwXeN3OWp7emGyBYkQi54FXl4+BkBHfEcf+e2a6NbWLWloLirx+22jZBE=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022Jw3ZvfFO60RRABnP9U6tRQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022d22f9562af11be44dbe1824f50f1845a5694bdc7f6cd53257fceabf7b9d2377b\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e002873.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e002873.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002873\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002873\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002873\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}