{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ZkxRzCVxdPgjKEu1cjB8qvWBdhomM+JjvQi0J8vHsb6nX3veQw15v4Mmzx3KPOWB3GpLGIoZM1u6a4HBfN5lkQetRV6GB0LD5ywY\\\\\\\\\\\\\\\/h4gcyqVqIHvfXBrUsEp92HIcMuhzWhgKjtvoqXqiCgDgtefG3pq9UgKkezRbJBayLVzRCUdE8J0wXzIGBmAaifVgn2+o3Kf1uiB3onWWqxhE6Yn7tx1igKsM7EzO+fCYPGIOVnXcV7T4cgdY2zGc8WXop1YGhazovZosHNMAqIJdTwHQbLw25NMlp7B3Rrd6S4aS7uAtpXvdRYTc0mq2PnX1Vwk0EzKWEdrIBrZE0OPWdEd+sT4yTbwlUrE9YFh5lbIAHH4UmIJLYD6z4Pnr5d5BQ+nsTjr2P+i4W\\\\\\\\\\\\\\\/mr6B1RKSrODxrx+5MeGHKek58gLGX\\\\\\\\\\\\\\\/HKWmcGberKSMvo7aU39vo2OgANXVxuCFsJn1xjD6Qq+oRbW4qhur1zr6dbxvprC\\\\\\\\\\\\\\\/9TmHiBKUb3aVBoSMsLrOymLnpBONCnlcAO2f0+EHSnJC5WVwW\\\\\\\\\\\\\\\/xwptfvNOE1etZ7IVt+L0TrNsONDLNOhatNMvO817ktUSXTceomxBf9YLimMCB9mi0bsdQ0OCmuGKh+sK7hfn2WQGddu2S2PXTkmfWULIpsaNYlT5ASkiTaIad2mo+wqomrCMFOpmAwBJTpiawAU9U3ku93Td7q8+gpoRzk5IfScQgE9YN8c4gpLs6UDR3YeOzR4NTm5uWlVSieTvrbgjAlz03ebjxCDHteamL0JF2AM\\\\\\\\\\\\\\\/s6lGWK8enEvBOTnj0baOt6bEJlpE38XPJ+nP3CFoXbyROxG2XNtqo+rzgSAyfQs7PM6vsfkc\\\\\\\\\\\\\\\/VEsyWZpYyEPs6gCR6T8i4VPzLkCDEk0UxCK2tMuJBs5ivaOuqGjFj4UuDJKpC2Zy2698X3MoKtfpFNJddf+QQbpF7l4TAQZDc8cQbpSLWtMdhwGdWQ7iCxNtgw5X\\\\\\\\\\\\\\\/nNmT6iKQ\\\\\\\\\\\\\\\/tshA2uhdyelkXRpyw1yRq2d3xXxR1Ria9r1vfojBIM87375qywquA+tPxFn+YOHmI658EvJIjQEmXbjA160z1sFhMGbp5HbrfXoJym5uNX0sXTkmxudqHyAXjyiTWS34z54+vltldaQzOwaYnrkTKj7s93rijWrQef9kdZEeksrutvQORTHWoWjHA+bbyX8kZ46ewVXWND4bbefmZqVMyR34o2jmIJmL9DCzvQ0ldcDb9gfJUzKmL6mZ1i9y17ttQHyOMdKNZPlRVLt\\\\\\\\\\\\\\\/qCpe8chJgHpYbvCWT4GLoD7mn2GrQgPwG2qxeRVdECd4HaVCVGeIwVJNBGWuysJUA34EZcuF2SNwSk0UF\\\\\\\\\\\\\\\/p5YHbPsQJeEDNrn7Y+HSWq8KdVKMY5e\\\\\\\\\\\\\\\/TKPOeYMqzOkiH7cleBeGAjiH0vdPeH0HiazDYo6LDxNQEZGuEzmg5nB9OoWAd5+ZLYEUsg8H0cxJXRUvmokoYrWv4fPgG4fLfBaFlH58qVQdj+RMIYDFdSN0sY5dXJT9vtSW9Pdywaqw7o4icKuK9LYXsxMVP2Dq6zN97gD6ijMCD0zsCXt53D24Y+GsiQz8mRiA51Seu\\\\\\\\\\\\\\\/GqPLyJgcNd1Z5Du2t1bo2fxtBDm9amkmcvdNErjuFhuLfodCd9GNHqUEXh\\\\\\\\\\\\\\\/HnWmPAO\\\\\\\\\\\\\\\/Qf4ZtqiwpK1+LwMsIoMT1+dqHJmrl6D9pH56jBMcHTfLwJRmmVc0zniJBPJXrJM+imnVSoNIKMSP4AHMnXnLmmBD6jVrujzIhG1PZTgvO8LfJXNfqbMTsys+cEWHuPSv4Dp1U1pcuVGij\\\\\\\\\\\\\\\/rPuSevsx60wXIdAbMuvUy4T3EnhcC\\\\\\\\\\\\\\\/ubgkQAYlPH9czBmob5UPdNv5bB3SLRGza0hRmbAwJYFT6SjOy6F+4K4\\\\\\\\\\\\\\\/Ne2sBtQqvR91Tl9\\\\\\\\\\\\\\\/rTyO8LbvVTyfNlSenfwI6BoCO3nkD3wAGlKBVEc0T2w6unvdEojtMZ19u3IGh2SvgbvbUtpq1UP4XbIRIDJ7aqLHyI25A9lT6Dc4xp1eswRK6sFbK+bfwwSBHXbOblw1FHpQiP6nq1SowtLod+8s2tq829YKMQisUpZ9Mc2qZULZnVEkOyAIwP7OrmGePwo74MvJ8jztSZNrxhg002qIu0NzOzVWW+GGybcYhMDq1MCN4UoFvsG7qv1Z4uVPzAlcY8VHj5r3my7pnIEDBjopfyiIK6tu91lYDlW0hWxGiLJwPmRTkcCAaFtxO6Aae10Ud93ugaqMNx\\\\\\\\\\\\\\\/ec12NgDd1ziq\\\\\\\\\\\\\\\/AxYxdaqhS9rR1hadg\\\\\\\\\\\\\\\/Ut5fF+TTsZV\\\\\\\\\\\\\\\/jQfGq9YbEHf4nEsolRTHRfwkjM7P4SGc1reTMkqhL1V+CiCzSX7acjd6suronZhgRdckVB0gHGuNBzqoQCW1boU+3aht6+XfO5P9D+8I+9tXGsaGfvaI8BEja+EF\\\\\\\\\\\\\\\/kM6Dpbm5NoxBNRKrivUpbzmOr36LXq1GbltfnwGFZs+8WBSiI5gl\\\\\\\\\\\\\\\/7\\\\\\\\\\\\\\\/UcWsxeBLRT8Oqeqm3al8Crdqg+1MH05couDbclg14aUqmrK9wsoLVaxKJVRxn3\\\\\\\\\\\\\\\/dCG0DIsbiJguQuOS5gPZ+1ouAT8p6YBhpHArSjN4+QpnAJUPUP4rL4Kqg5OeaboWZCmBoDqDMCvZVuNY+w9WUce1FOA+l5QfF6\\\\\\\\\\\\\\\/Dqthvg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022lgRPnJrAij5x9A+aPymb2g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002242dfd624ec3e26c63a6e5d525d7ac785ae0a0eab37fd09f846cdc8ca72291bec\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e002545corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e002545corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;9\\\/10\\\/e002545corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002545corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002545corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002545corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}