{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022r3u2W5vnJyN3s8iexcK8IVC8TBt+ig\\\\\\\\\\\\\\\/opV0+1Npf0L5P73xF6dvXGiR7lcgIuDPFhxZMovKEbzG3bkEB2ycVoE8wo\\\\\\\\\\\\\\\/U8iPTHdaxdbr7bNosuTtFUblQ2DIv\\\\\\\\\\\\\\\/0VLvJaMXDkDYFGQeZAT1l3F+rx0YzCuh+wEzGXdcLOW\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/aOXDdQXp7Os+YSfqhP7+vJODvCwfYMOe3sq19MbQYPnasN5sDZQGq4qLSQuQyQPF+\\\\\\\\\\\\\\\/jec1Wok9rBagJqtGcRBDncokYcXMGSdC4Ev66TrUy\\\\\\\\\\\\\\\/ClqODm6HrfTARHES2faue7diBqsF3oyegrus9e3MU07l7uf6VVg74Htl9U1ciSSWzhbQ8NmnihvVUfC7tRxS6pYeI6S3y3yfgFDMnSFlcm8bfbNVOwJJ0mAADtTaHc3k6Sb0FNAk\\\\\\\\\\\\\\\/pHg3YFRwRB9yMC6tRL9nU3f5mCEAaaJJDXxeryQzygvvZgOwoC029dTwaoCXtpQzPWEWCZdrSk5UXY8qqFn7faOvyg1f00Ujwy8KV55\\\\\\\\\\\\\\\/2RXDwexUqIVw8ILdqytGIVGdDFrxNybZii4J1ZuYYTBQ9QLakAJY5B\\\\\\\\\\\\\\\/d59blIx3dcNCfoVCvM46plol5hNVW4NjeHQJOkE0wJ0vWV0Onux95tL3lOcq4YH6gkY0j3SsbGR5AzA2RVswIvGpl2GlNlSMQJlWI9rJfJ3m0Am3LxRh+oGrsd3wm2wIaLhC59HbBLXd4yyipk90FgjqCONIyY0ewJOOlbBn2jSxwp0W7JFR5bEhUgw3McM2p\\\\\\\\\\\\\\\/+yi29nPMvVsn\\\\\\\\\\\\\\\/kp8A6UeXS+UwOg4pWzB7b146xsqdtY+WBC4KoEMKKiqDG87hMinv13g8zalIdbIn90gMRQNSAibYyICWdsEa5IJV7EoKdvQ0IwbgO+aZ1ci4vS3OaN2NkXnaRX2N3GK3zAdyyjwL8rYbclj8uzX+ueTjkqyKDU1txVhMkuWcTCjB4G5lxKFxceBGoPS+ts8cOlTpWI9bG9ZIfsHan3Cl+6KbwpQyL9Hqlk4HdMLUxiFeSslpNyW0nwFL7Som9sI3Yzfhwr5xYDVWlDqAYvJVCgN81i99H1HmfrS6b6uT0NhzibHrX3V7cqcu0coeenaYXgeN6VWSAtMY28hebz1E0H3pOmCypfSpkPlrwvhZY0dAxfEsgm7w3h9MRqoz62RwPDJyX5h50HB5RKcfyM30WSKzOvvjgD3V2OwRzHTojtLBH8NKLAeUz\\\\\\\\\\\\\\\/V2vp2kezqhvXR9yZsGSkwJvGy52oOOX1wNxz8OYrs3rhqmuCb8H8j5KHQ+KObBWp1RdUSV13s\\\\\\\\\\\\\\\/LIs74oAeZLFkkS9hBVlE8IyZPbNn87QHbgOxY+ulHy5UGqCxrbcIJrz3mrR5qFvA\\\\\\\\\\\\\\\/egqk3an0TolQRsWhf1VgCb3EPEGu4\\\\\\\\\\\\\\\/6bzisrA\\\\\\\\\\\\\\\/GTwJ7YZadoGhpnVlZ\\\\\\\\\\\\\\\/z2Dz6t9h5ZRvp5p22yFDMXNaQmfpZ4YV5rliDZtpzeYljXZxpzyqm+I7NO7QuN8I1Q7dO9jn4+545aZ6K5LvEUjf8axjE6vvzNkgVLO918UblBa3LNyGYQj4jaBLVcsp1WROiwckzfuNPLao6GeiEC0y2rDBD3GXOGcNWbbpyIKs4eopPw4MKP7NdzgXvvPtKyRwtSiLvA2LW0AT\\\\\\\\\\\\\\\/c4dQ\\\\\\\\\\\\\\\/gY3+hOIMQR46qeshuKzg8BRuyWPPF3w9P7el8g+UbdyCYu6zYXEvU92S0LpMkxC7VKGhdMgMwHHzLpujXzW9CMgI+3uef51S69ZX7AeLjb2r0AXcbjm\\\\\\\\\\\\\\\/4V14Burw0QFV2NYNskNnLsZb\\\\\\\\\\\\\\\/hp\\\\\\\\\\\\\\\/Dh2bbvVtXVdToQeIUdl8vKSRmyMwbBD62KKsqfER2JhKrZr7VARA58MVkp3au1hLwVm5Dt3B5DGl5hnZEk3KpJB7SwxmbzQNlyOEVsGiSigWl2Q5lmjJgTRfpyHkdDUzhQjQg0xOnbEofntLR7AHvNDQJTAYGqT6ZLYJhfsISdLqgMmi1JojKfy\\\\\\\\\\\\\\\/XmZjbNXk4nwbKdDIFqkl8jV3JwLtWUeB65fbZPGv8GA\\\\\\\\\\\\\\\/R0MFWYVxou1IoQl5RasVAOAu4WyKWWuL+JYflNdXXBHb4gxy6eVC5CqOH+saCsiOLPYW\\\\\\\\\\\\\\\/NN8Bbh8suqTDYd5Sr47VRKivRFcjdSYMGX\\\\\\\\\\\\\\\/zLDcIMKy9Q6e79Z\\\\\\\\\\\\\\\/TjQ8Aw3ROPgHU8gbLSoTVxCZlpDgvFK+cslIhP6VQWPVKsrU8IHXECLuLX+cL7PWPUTgSMQuz84omsau\\\\\\\\\\\\\\\/PoFXl4cly+iulGNu+WcbiXi3B8cFOphi6VgczFrT0T+xW6Qu4O74OBLDvfW3g0Mv9kEdh+T99D6O2HFhaQnboj6pyIY\\\\\\\\\\\\\\\/y\\\\\\\\\\\\\\\/W7MtHC5Rlh0wj6jksCSDCSMFXuCrEu4t0a7msZflUbFQT4xJTR9dKfSRnRk6WrjO3QWJfg5xXmZQe0YlkHpD7ZuYGr4wApTDW65\\\\\\\\\\\\\\\/Y066AVf+UzlaaLufpXApBb1JR9AaXp+JDv9BeBwjqHvt\\\\\\\\\\\\\\\/kczAki2PEjitZhMs1jUdgQz854Ucx5yZlnlgMmeA6Wr7Mt3U\\\\\\\\\\\\\\\/lWZ6DJnVIFT96h1mr58ucC0sKd4ZTmPVO9B+UnX5uECfergoIS24PD4AcjLa\\\\\\\\\\\\\\\/DBR3iTgm2N5bUCuVb+A30DYu8jAj0GYgCuHIhgOXEKwTDDhqv5su2XihEk=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022PQ8UBGqdBSzPQWFRkuFVow==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022db0d32bca113685706c6fe9cb76badc9b253e31a266570606da4ef143d541d35\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e001624corr1.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e001624corr1.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;9\\\/10\\\/e001624corr1\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2020-001624corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2020-001624corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2020-001624corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}