{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022nScFmDNXlZjy1gc4P0KywIXfdhko62b1ugrJAygnoDKG+PqL1kvYqTp6zY0dyIm0trsg+wf5yB4dhSSwBKLvYljxT\\\\\\\\\\\\\\\/TP\\\\\\\\\\\\\\\/S7++yO2v7fVTgNlUx9Kw+gVfLDyd\\\\\\\\\\\\\\\/DY8\\\\\\\\\\\\\\\/CsymioLnap+O7UTk823znXVExFTM9cHy6tifY39Fk2zreH02jMhvwU3XQrhiXV7LzRpVhvsY4yWPzm4ESO1x3DXQab5olh9nj0uYS2NTbBDeCQtrlGXY0iwchgz4V15lVPXmgad5nwQYssrUVqNRvLQRlRuNw8iKURkjnYi1GtY4BhU0tw\\\\\\\\\\\\\\\/s9u89c3Jtt5CHqk5TTyqTxpyvM0eMCxnc7OVUMAvLABxxBbAyUnwFhpTxZhWWghQytv8WvaFmBtsZQ5jU+dFXfa+4LWXPh\\\\\\\\\\\\\\\/EPF\\\\\\\\\\\\\\\/fR5btuI7KUG18dvchx17DpskUHrEPYYW1BHrHd30YTCMI6miKvn7NZwRABwnmJvxVJ6AHkSNYvn3g6i90pf0Q9jr2fOGMmUJt9GS2la71IcYUKUkfTg6jHFarqDF4QkZCE8Ow\\\\\\\\\\\\\\\/v82Ff9E+LEBJG9W87bdp\\\\\\\\\\\\\\\/oB2jQ+mDDcjBm03HGivu9FstPV0gcp\\\\\\\\\\\\\\\/onAM8UneMnfeYp7Wo4ue1bVs9oVYFavkbTB5GOetsC9WcexU2cTuh0KrCQmhi571Nfbdk+CD4k2ryqmyT8h8frJSjO2bwjCVNYEwQCwv7F3xAMxIhMUECFOzcKdw1vrT9kebbimJkkfucdbAXQEkRVjhCSmjnJhdIFeMc+5jHsj57a++uTXF081GXGF5ugwXODrRaP2IU6WMhuzTG1D335mUs3\\\\\\\\\\\\\\\/OY\\\\\\\\\\\\\\\/OsCt\\\\\\\\\\\\\\\/j+bCpNrOo+2WNkuBlkLAanwPogsjSCDS9oZ4iyigY6luz\\\\\\\\\\\\\\\/6ZTpwOU3kOa8htJ\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/mVT4Ah5aMJjTQmtyg+\\\\\\\\\\\\\\\/Iaw0M\\\\\\\\\\\\\\\/WYfJ84+1qKMAw6eVXFHzFvePiye3LLIKlmbgodTEeaJNDVaU33e5qci5mbnLPkb0JBYFboEFRXU8up+y2k1pfNvGcpZoY6owYWK0QnS+hJnq2U053PDsDiJdR0ahspyOZuCV0RN03CZXCZ31k8jfu1sloeK2tLWYE6WIQsSS9ICNLgoc3paOHNTrj+A3LGqEWmK8h+3xpX4mNQ9LY3AAfD9sLplY\\\\\\\\\\\\\\\/C84Szj+g\\\\\\\\\\\\\\\/l0ZBYarrAINOMNDyyBrIEhaVuPQXV4xe7sQU4hIQBmQ7eB2ua8UWvmQIWF0g+K1fRBNiV1YFwY7JkS74I18X0ziERiY3ryKlV5BAbVh6TM9cDyFW\\\\\\\\\\\\\\\/42Pilm5c1DRdAGvM8LpNvE2W4dVeZRilnc16XRvB\\\\\\\\\\\\\\\/tkVAwthnQ54FyTYktoYTn1kOIB92Q+FJKyokZdFAM\\\\\\\\\\\\\\\/bjTQ\\\\\\\\\\\\\\\/iLlzUGGso+DyWmvUs8I\\\\\\\\\\\\\\\/UMoAmXxdIyS61thopCVlP+3gvpPEmsgzHjeKrjtnuTcm7n9N94wFVokEMutakWREmHQ9KiUDljyYXBRjyiMeJeqrgSJNqkaW02\\\\\\\\\\\\\\\/ePdNbk0qa+eFo\\\\\\\\\\\\\\\/qDgf8gr3qNchj\\\\\\\\\\\\\\\/Vph1HAUtPj0b7QVhpYRVspldI7gTDkUExokUVzm8gWFNcBdltJy5moaoUY0wKirmiQlUbYskCzgUSeqdCX+fe4kch2VmeQ0vycXbe0kX6nRWvqRZxXYL7J2gLxqAgP7WdbfBdBs+7mhTpjPdCrglTK0DLPvMJ0jt3hzp3a3TQOx\\\\\\\\\\\\\\\/hjnM84Zc6wENwUzZxQ5X2vAgWo6n6CbS9ON6kAAXAHZyJkU1oHYwAyuGo1fW0Ew0SoQwZTP7G5dPy3S9edhQKbG4UhAGYHAG1IdAZ1qI2+j6QW1z+8wEE9ydYUDVfb+JGpczspBQEj0UJwI0glEMfaWSrUq\\\\\\\\\\\\\\\/UT6e5GxPe0k+oJPZtzWXPYrIy577f8S2a7KRN+F+VPh2\\\\\\\\\\\\\\\/ds2MepVWcAZLCEZ7znzoXg2vRTdmIeQ7auDYCJW\\\\\\\\\\\\\\\/Q1VjJAYaDW+sL3tebvfcQWpg0E+gbceNUaOJlmwhzO3aPd1y98QZc8uiKULOTyZIE2TxAWVJRgFDRUFwV32MRNPFfqp9m0SdwtiSI\\\\\\\\\\\\\\\/Xi4P2xCXkOkZSoaBPQCUAnBvqW716qmB\\\\\\\\\\\\\\\/TmAcGnsFlaL5Ia8XW0Pm3+RN8iEp9Z9NYaKhAZ+Z14vAh3YO+qbr9lkjLjAzhjRmg4pTs+o0JrsqNoX+nv5jGkO2jr4bVNZeMgDLBToothQPiJBn+Rz0Szp\\\\\\\\\\\\\\\/ivOpT25S+dKuhCsPkl6g\\\\\\\\\\\\\\\/8E5F2r7WNOwYaLNLjqZs\\\\\\\\\\\\\\\/ZwCw8a4z0Ocr2RDdoSeaXN\\\\\\\\\\\\\\\/MDgs3Q2pSGu9qs90L9+uYtwf\\\\\\\\\\\\\\\/eqvzORjnzggPR9zPIHfye+KMN9OmpiIbpm0N+MFeztDe24svIge\\\\\\\\\\\\\\\/Xj6hmmHVDSpFq+0UhPK81W3CGEj1Che9SZM8StFU3WTyN95fDwXH7Qod3iRL4gwffdN35WzfBInOA7E684n\\\\\\\\\\\\\\\/PF4z0OvMpl3YButdMW0Vn8bM7SHZbNkSOZPZPFo1GRycMmaOTc1ZiA4T8HSColrFg97Wyg2oglwcgJt2NQa7INjpGyncy9MpySsXsx2S23e2VGJP6z\\\\\\\\\\\\\\\/xzRVQ+pBKgPBqmSEcIGxBrVw0SHHT0XAjyLc0jgfwdSpqVQ9rWSrkEEGazXBB8dfka3nEGcYQCgCBDEzA5floFOFU95z1zgYqIdxloKobcxzMKc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022aaULEf+wyNmU9HhKbeOUmg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225f64741dce6cb6429be63ebfc57ccd004167e37aba72252c2b80ff5275f1e0d6\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e002836.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e002836.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002836\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002836\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002836\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}