{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022ypJsOWk9FaU1YISxBBh3ZkWVPYULKhLN9hhUIdJ93VdNXnCnOLSLK91F1\\\\\\\\\\\\\\\/YpwBMKKWYOnuoNeZb9aBVvSWg1L24vl\\\\\\\\\\\\\\\/hZPGNXbtwXFitsqaEA0+hIlGdKkpZ4MTaceDhWclNnp+7q3L9eFuhHhUirUWoptV9Jweqql1dShsTTduvmj8ZbdEf7oWT+ZBruSXI+Gvd2ncEQ367FyRYy5X2AuU2Xbs4IzChZDKYAK+3wpi\\\\\\\\\\\\\\\/MEJk3m8uYadUwnL1EvyJBpiIFw7uVetWpZbSSXKvZ1K0ZU77+k1XzE5tRlmM1\\\\\\\\\\\\\\\/hL6h1y2jxuC5MRcRrP0qZHCR1xHJlgeGmtMFQTipReYAFf0N7Yh\\\\\\\\\\\\\\\/IQvVbGbTu1Pw6VJu7SW1pgp3gH8iVOSAZgt1UktY4WD1Z+qWmNMSPvq6HSQzSYSVpjpwlSv5JSgo7ynZcqutLj8mDzyOqd0pDg2ZUR82ys67r5G4NXS+SKs1JVYFC1585ROtATpVZFhyolOdRTfzU3PaAaqypRzluN+k82SskijD8Bol3xXlz0YuSBJzqff154nMqudoxJNjIsdOUx4H4TKL6y2QMVWMhgCBXchL5uXmORGUFCuYxaW+d8F7Ykb9XCmkWFBSYMTA4VcDetf1nntd+eav60z\\\\\\\\\\\\\\\/NOYUbRsFs+gNIAVABc59c9GEJBz\\\\\\\\\\\\\\\/VvakMYyY+cNCPobc5AWpp30N7a3VOq2DgXy5TwdkyQAe3c+fCXdQsJlEdTbxUOfKIz3wAilBzcx\\\\\\\\\\\\\\\/cgF9lo9vXhLYV+n91khIj20yQT4SyvlSELWoLWqQzs6pOjtiry\\\\\\\\\\\\\\\/uf8jN4b7\\\\\\\\\\\\\\\/Pb9tdfaZJyyLAKKWWVL9ufFp5tjvpuRjHOKsjlMkgU8oClkH3e4Yo1VEBSR13FVOSlnYeSNj1zR8yvq9qiufjWI5NR9aOV1zOxIY9OaTASpiTUvOZTmTXmc7RK+SXzHu0DzX87flJRQL5FV7lFGitvzjEbc4Y9ve+zszvJpXC481pt3p44gHtL6UYP9gqLfARGkJmH2L9pHlOcCVBx0N\\\\\\\\\\\\\\\/s37Sd+MzW6Suq1TPfJBMBXp2H6ReFEmN5Ztwi7W\\\\\\\\\\\\\\\/k69O31+fQpaD3MNDwKEmutaxwT741Euf7GO9LsDnJP3\\\\\\\\\\\\\\\/FCiSwcRldondePquSFf0L0\\\\\\\\\\\\\\\/eIJZ5pL9CR8NlZHq1yQq3+yENF+yV6xQS0MjKODKfsig\\\\\\\\\\\\\\\/ZRxbCn\\\\\\\\\\\\\\\/2ymtRRY01S8bSMUjceQXD2lGdhw10S2f8wyusuu8i5g\\\\\\\\\\\\\\\/mRVbTB0kmbu+DoIW5gU1S+QoDZuTv6dJVjf6GnUEjkPM3oWX48L7STH8ShvtWdnsyKWyQXFx\\\\\\\\\\\\\\\/qc0psDjnz81Ox4+h6qNFtRk8SPAna+z4WajyNOBecKRvChLABYCKEAqcpyDX7GFdaqWZS2EjEX2CrFnGV3RVFzQuhd1l+w2RgdY2MuXdJtXw4L8uS4\\\\\\\\\\\\\\\/FFrr3RSZC+Ulv+HNDkY1nPKvoQIzzZdOoAXk8M08xV1B\\\\\\\\\\\\\\\/iPPwm5bWpuwkPKMg5yTrQCyDrr+oh+91v49hZFzPGVZbS12bZ90VinpkuUH7BBQSyhhXg88d8EHnomrNncxXAPFt7Q7QuCH0y6DR3aUD6lZ6S7V652CMYbz7af2tnoUIGwZlWBFBDykBt2wsdRVrNXoR2y6hLZQ\\\\\\\\\\\\\\\/BZMyGtqswqYNWOBSILZ0phiPMVLRE3VC0zrZczxFSrtTnH8GruPnWfbygL6tNMClnutsd\\\\\\\\\\\\\\\/D91BcoBEk\\\\\\\\\\\\\\\/YX+9gU5If7lAFCchujz1wlC06l44XNy0Dm6DwrfwBZAa8QJNMEXVrShp\\\\\\\\\\\\\\\/lpWCmd03iK\\\\\\\\\\\\\\\/XqjjYAtomDxf3Ye8KvKDwlnmugurbTfwpBESlXNMkYe8PZae6qj92nmiLty376bXVPKulrD75FA5vixD2Ail7elMZDObEBmIoB\\\\\\\\\\\\\\\/efiNsc2Lw0shQXl6s2f4PXaJaFOiawb3qjRA06+7jpEtEjzgJYS1o5i8LovzZQp7TuPemGjRxWwNHpzkjocFlrYRDq25hpKY0oOVwKLF1ALVmiPLU+vO\\\\\\\\\\\\\\\/jsh1b6FyAzVYdyXJr6pil\\\\\\\\\\\\\\\/2jvNxGH4efzsbjeYb47wUdYacAFMSzMQbQvQqN3yRAlsmElf8AgGB8d3FEGhdgqs2ZJnLPe4xBDRRVxddA51rhgYON8slePwNnaB8402k3yta4H6gly346pJReqnHwlltSVTM3HJONEsJNYhrEz7p9G2TVjePLmOmzLzUnPM5XNPI1ZmYtC115q9oOMApL9DJg2edPO1YZlTHC3EM0sAwLXe00sequ6j3i\\\\\\\\\\\\\\\/KaD+xT2pVjw+N+URYH1WdjUK4wxQFfaozjIQWqBRkXKaRHVvJZ05azqZeUBdyq9C954kn9BkrOC3ygSfeccwG17d6uyDWjLG2\\\\\\\\\\\\\\\/uFVlepG9XJJtWgoXqgU5hM1TUupnZCLki28c77IIVso\\\\\\\\\\\\\\\/exGtb2g2iEPzY3CpmCgAqJFMNwBHnQpvJtrjUdA9QQDu6l01aLwHdWPQA\\\\\\\\\\\\\\\/iHN\\\\\\\\\\\\\\\/1M0e31E8FA8q6w6tjfYcq9vC0dd7QP\\\\\\\\\\\\\\\/qYTfQksF0o10DtLX0BJIVBffiNrT8da4oLudOIBlZSWFT9Mg5beGpLfcZzQT+QmDzVrE+Yv6\\\\\\\\\\\\\\\/5bri5T+JKFQgDYdKLEn1O0SMhHMS12SUoZVktinif3gwo9eOhQAKsjcQcktRsf488E0k3rK4=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022XWCu6JINdu0g8GXnE5Ti3g==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002261a07f47b3e7d33db1bdb8862d3822eaa03d40cf0b5a316b47c80bfaf7f78994\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e002663.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e002663.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002663\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002663\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002663\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}