{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022JykKQTSeIq\\\\\\\\\\\\\\\/dIzk9TndtDJDuRfZdpP7Am6beXrQu5l2FfPxkxQVK62cQVSN\\\\\\\\\\\\\\\/2Ob5swaEl04YTUs4KzYZg5HqaxsW\\\\\\\\\\\\\\\/YdlDNG2Dxk+Jx4YEry6rNs83MV\\\\\\\\\\\\\\\/Vfw6IN75e1bqwhV8\\\\\\\\\\\\\\\/atvxukIZ1wWRAcf7a+5ClnUbB3VGwCufGk2zcBgRGvfFeLzm0Ddkeihxh1FyzH68xHkdYSe0BLXBrAVzm+UNtmfWU5Gn+SQ5qAdR6Ymu6bLwV93Y3JUtk9rfhRUA7PRH6K8hFCBzG2rsqNoZMrGxE5GXA5UFu90SCcvDw4L\\\\\\\\\\\\\\\/G4gKl45zgH2EveP0k+xZKqAguWvGsqSXu2zsW5MX8wLKcgWbv4SJaFhfh2MJ+cDDFBb3yZM8x6RYCR1vvei+DEi95fT39\\\\\\\\\\\\\\\/HRTelI+ie3XlcFJRcuSNnwzE0FcNZ3SJaT2KtsFlxSIZbyWYE\\\\\\\\\\\\\\\/E7ucUKClVG2qb88tUIvF5GWcmHpy5YHiTyJJp5BE0cahSFdiM\\\\\\\\\\\\\\\/kb144nB95y9UQDQ0ikaHeFTVyIAXcnBLuHurdl3WdgUB0KBIjTtasRV59sgi6972E6wdpQEndn3cKMcRSK953iS2xwkddcTMCdPHQdf\\\\\\\\\\\\\\\/iHBRdTZexS3SXna1Fu1KWXB+dHc80BOCDN8ncq2cBK7K\\\\\\\\\\\\\\\/ewZR52sKiyFaNNYXUC2MWk6Mf6JTu8hdlGG67FdNdXEXzjNLJ3jyTZyPAKSOiBqJ6yQ4PvquJLqbAIqIcwsmmUMt7ibyi6ZbPjKKEQbY998d31eBCFV54SIWrH2+mgOd60xj38i+TGvESSoAPpY23\\\\\\\\\\\\\\\/xgICubQ740vyoT2wRKwqQwRpqhTp1nTss8PkyvBzlbefRO\\\\\\\\\\\\\\\/+BsuExhPp6iOLrsHbPnTWP4R2\\\\\\\\\\\\\\\/uIS0uSAghFr7aAKH\\\\\\\\\\\\\\\/RkpRbJDbhkq1JrQtnYQrDyhwKW+ZDIfHtwR9FFQmg9UfrpZd8f7kCh+ejPcOuzJDmKOnVG2CXHabgyVOD6BcXKaCxhh9sCFZZCAvwPFnwXBvA\\\\\\\\\\\\\\\/Wi0yGvUZQ3voXnyNsK8SDa08\\\\\\\\\\\\\\\/NxK3h4yEiNwuirRRQVQHOK\\\\\\\\\\\\\\\/skiKdzcNB2BgovTHb1y0WmbUfOBRgEt69njWuphjA3V4OG1YaqDUCUUPH0gbU8w5r0IwK8TyPUSvgpl473IVfX7YDD1As77y92zHwgMb0Kx2EnsfAzu49Za2fN4rvz76adlJj2vc5Ihc8kru7lWf43j5Ac3cqjqbd\\\\\\\\\\\\\\\/RDpZNUDVJC8+jpqvx+G3M8Mz7zK9J+qeAi7aWICi5mokoXxX7QeabHVz0PDciFxSRjJIfByK4zXKhSebNMLoGb23cpZxnyaaxPptQOIJQErrs0bCp9li\\\\\\\\\\\\\\\/I9TFvNLI2GbUO47izpnwvyGYzr+gmkMOKdQd9Axj01LU9qjU9\\\\\\\\\\\\\\\/bYjzzzm70QzyI25kLl5ES1C8AzwajsNSP962xxIQGVzsxTHw0Lq+UBr\\\\\\\\\\\\\\\/SpUncDZoH6n65q1UtBT8buCa\\\\\\\\\\\\\\\/3oCTRelunYjQvo795fp\\\\\\\\\\\\\\\/hGD16IPp0m7U8of0QHNW61NIy5WRP3XnH16a4aRMtkLcckWWy9c2hVrUf4ENz8AOg3S9fFeT2Ks1HuEvrZyLkCU85rbNZh2O7Hi3wSHbiRDr1odO8Hbbfko5yURojcwm7nxayiXVSqz200ADxzPa0F6\\\\\\\\\\\\\\\/SC9fQgxtv09PZracOgiOgYYLEy\\\\\\\\\\\\\\\/aJgnb8AzjzhXUQ4fJWVIrOmz6azlWW8pCbCuu1NVV2svL1cNmg9eyCAgrC2bG\\\\\\\\\\\\\\\/uh8xpa4xw+H6srfrOLnz3+DW+Sgf5gwTSqVM2R\\\\\\\\\\\\\\\/KI46FxQKQxoes3ixSqqaUqstPO3L2bbGToX5H1s6\\\\\\\\\\\\\\\/M0P52N6t9RvtFuiRJrsHMZAEUPXDdukPO114nP+KOPGDlyxPLAuInuEHjMJBEp6g+514HYdxcxnic1dYVu7rL928UUdSCjv9vwXJ\\\\\\\\\\\\\\\/RG9jOBEfwp3e\\\\\\\\\\\\\\\/SeMVdgtHC1OVhmYqWkkJj76wEiSsCSxfUeGLf4+aTeR3teyLaEWKQo6cTG6NkoYCwJ6yOUKTWGZYTMP8uHrXtoY+mMcWQbzk1O1BcJuWq6v6ialXBbeLllvdozjHrmse\\\\\\\\\\\\\\\/Hcf9vxuJh23qvyFOXbgofoj8245joIgVfK+awO6tIMRSl\\\\\\\\\\\\\\\/HWPoBKS7wR4mPsngEbkYb\\\\\\\\\\\\\\\/gQLkjZZI785J8zriRWVq8ri3Ac46B0K9LeH1NxAW2VqpHbGUIVL6R7n11k9Htoirm9LbLCSjNzeoQ1r8ojiJWq2XrgDtTOWqb+rp9+2m+SnmPGISYImQSwhhiXVw\\\\\\\\\\\\\\\/PETgS6k\\\\\\\\\\\\\\\/vxTwPNUEar9ij9tTmt\\\\\\\\\\\\\\\/mlv3vVbWZnAmReQR706rv+zbR+fsszVWZqCjK2\\\\\\\\\\\\\\\/YqTk3tqMKNZQ3ojabdOQAgtPiEmGFT3p4Df3LFj668QLQT4eEwEvMP6R6gWEFtYdpHduwmgjXTTe0h31pBra8S7rVMbWY2JKcyrGLcRc6cwjaI\\\\\\\\\\\\\\\/+yhShyxtxZdOXvzQCq2AyOiGg\\\\\\\\\\\\\\\/nE+CtuHp4peZapyKzie1PxBi3BNT9XcoAKrjZxNZnSN48VQNMkSLJ0n6dntZrwYH4YoJK3mkT9LxCp6+aWyqUU9GbqCvco+pmcnQt1nQWvx+DncN4S07hBfyLSIMEft0qOHF9B\\\\\\\\\\\\\\\/lCRVZV1vZpgj1d5VWMAK6BxbC3VgIvDvQGNA=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022glcFQ0kfUEso9dQYUE93Rg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002228773adef893e447aea02d6fd93a0540d34ce78c282c0d2f586ab4f0411d1aaa\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e002387.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e002387.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002387\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002387\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002387\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}