{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022cqIYkhcT6XKiATQSO7\\\\\\\\\\\\\\\/6xY8EPM8gDv1YSYGndR\\\\\\\\\\\\\\\/zoP208DzZ7res285r9kPpxgCziCCn1C9G+wuKPFMeQzRPjNLA2726jkrgxbcIGHk3M8VhhrcSpy2UasR2nux\\\\\\\\\\\\\\\/YfMTOaN\\\\\\\\\\\\\\\/wGBD0EWpGJOb8pb56\\\\\\\\\\\\\\\/Em3VcMtCEBs2TS67eoXVVGi1QG6FUK4INmuTFJUASvE+GuI7p\\\\\\\\\\\\\\\/gdLQzhuSwT0UfmY9eOThE3mH\\\\\\\\\\\\\\\/s6dF4SXU8\\\\\\\\\\\\\\\/q3SkCX\\\\\\\\\\\\\\\/CMlybPswAfSZgbwAMgc+9LAOhHCLSFg+q9bzoq9MbiXnFLD0u9u0TTYuSEhlg10BS9y\\\\\\\\\\\\\\\/1GZEOO6XObLUWsW74L12dcm3wl3P+TF20UtUOMZvjWxBcDz1DkzGSEMufoDI1\\\\\\\\\\\\\\\/UPUAi5yUrBnP51yonBIPu+HC3fh04kNaYIGlSSvhNLk9WuLHIs3uR1kJDeTNN3NN8W8+Y2BO9\\\\\\\\\\\\\\\/UJjd5qEAmKQSjTX8ypwFefe1EZvH35VQvPb8KSq5+hfDoO\\\\\\\\\\\\\\\/DYViQKcCxHbJOufPpROROK4I8U86gh2roXOEK3cuOnIzEDT7Dtw1OmPhsBAfp2ngH36rwWTR\\\\\\\\\\\\\\\/y\\\\\\\\\\\\\\\/C9bhbTkvoPjCdI63IrokhXOK9cTLkjg6i42+6QL8mV4MSRGN6Eqo\\\\\\\\\\\\\\\/0ybZ5io9Ep+NCV\\\\\\\\\\\\\\\/K74ogZT2FEJ6zsBByUfjAjvOO02QwUVIZHzkTezx57Hod0vo9kt4Yck7Q1fZLJOP\\\\\\\\\\\\\\\/D+iFM+ujKkfN6n7GSfK07DlXjR5WlG9x1yBkbd40p1M9MG4\\\\\\\\\\\\\\\/dXjcKyii22swvJ7ZKdRC4JD9\\\\\\\\\\\\\\\/1GpxhdI5SgHvIfNsSKDHQC696v90s\\\\\\\\\\\\\\\/MosTuQd0IVAXdFAHOHdYmG+ses7FRXoVv5Hqr81ia3wl3lwrSK876XLs7wlldO7Hz15M4d4tKK35fz4DNiHOQJzGErEYA1\\\\\\\\\\\\\\\/M55NVPXMOmSdFEdG+J6R1WTsOyW902DmEOxJV\\\\\\\\\\\\\\\/URQAKG9TJ0F6N9QvtMwr+qTWxivNXrZjCbDc\\\\\\\\\\\\\\\/KkJbeJ+ya\\\\\\\\\\\\\\\/0JGWiTZNyhSDrdFy8BwKwD1Vqs5kA7RWpJ1XJi5seXyRw7meuSmg60bmsL1hnbtzrKLgnycgnYASBST\\\\\\\\\\\\\\\/jdJSrNoKn7zC4KwMlv4Ml9HckCEdbvuO2VQWTwevKkz1JuErK+42Y5rHbEF4f7EGqhryytCSY8DwWrr8W+wWba+oXk+uZR5ZVXkv2a13TsyCGBBi4OlQOn5JwJyoMIF955oVzB441VC2lFxZmK7RhDvCHqgpjzaNvUcBl79BXp9I1llaVyrAdl3ZfUbGaWOmK007GqbRLHmfEzymUbylNRds7kYMA8c1ikLIs+gCpQX26wNiDr9laTJPyDbP2s6UFCXwMJU\\\\\\\\\\\\\\\/nqW6aDe0PeBKMcejuyoRJ5b4PDfCjdbi5xUV9VbqzemPWObzM7ISCTjrHg4K\\\\\\\\\\\\\\\/iD8KxwrZskwmuhqXYqVLmZrXInd03cmGSxW14kvaBoCsCJTUtdz7oKfEiQgtUNNFZVyznFr9xSfZeKN6bC7krqjitqE3a1Cht6zqxh5Vvgje3Poqfcr8j4kf\\\\\\\\\\\\\\\/2e6JYi9mAkG1tj\\\\\\\\\\\\\\\/23Z5rnJFKl4XeT6JtoKN9QGSSyP1fK3U6jEasVzEHvFtcdDHZwiCGqqifgf80IimhnfyQ7iez2m9QBK4kH6mLE78AtbzfkT6qvTg8SzwHAtHytS\\\\\\\\\\\\\\\/jdthUSm0\\\\\\\\\\\\\\\/c7K\\\\\\\\\\\\\\\/3eK+7l8cxmpiCty3ZRPl0aoeJoae4rqgis45sJn0HhP9RF2gzZK6ijCqaZpH8nA0Ghb3n1AmNwtO+lZQ+hsKBkzBXez5pOnagWMkN0t881Ajxc5sSE9EDMr87RTnnNCtgTF9cqazo0ZFUVeB4vj72QmNuyueGc\\\\\\\\\\\\\\\/DpBvHD0F\\\\\\\\\\\\\\\/VvxH0maHKSMJQUeGPfaxu3vkXXt1qQ0KlDUXrp7pAeZe\\\\\\\\\\\\\\\/Yn5JpF37+8FghfJVNR1\\\\\\\\\\\\\\\/INfeAAvwayZsU3C6mVFCR6TulMw7CGEoB7KUsc\\\\\\\\\\\\\\\/SrUdgZd9kNG+ND7NQgeUUftu8FiMJ9PM\\\\\\\\\\\\\\\/qj3iQh3VqLZKc2HwG1eErS8AveK40J7KPuLYuhI2thHPmxR9NMNoGfr03Ayd+CFGHCPG4LQ\\\\\\\\\\\\\\\/AH\\\\\\\\\\\\\\\/80G27pIHSpzPNg+e3iAeSzGofUuG1bbkt\\\\\\\\\\\\\\\/bmGR5TryF+Fl6DGYiCpnDMFXnRr\\\\\\\\\\\\\\\/rMfDocAxZXqwUO5Sp7guvrTDPiIvZ9kAt7alwAPCaOwXK9k8PAp7Z4Rot3DaOdVnwvNRl+qnDMF7gOZL8Q192y3sKQGYUZCC5RdxyBZ8odAlgANLHj8S\\\\\\\\\\\\\\\/QY\\\\\\\\\\\\\\\/xic6QRRwT58g1Q82kNgTFSXnJLkdfc\\\\\\\\\\\\\\\/hIykSJY14H87fCyvDJeTwDy0b\\\\\\\\\\\\\\\/UHSZW46HFcKRDlhHsCbn1Lc1SynF3IjfiV1iFsOOQgRp4w9T6tIeSJrJR4HsBHuoUGYfxHeVYOBcTwGZIqQ2+rggTygRhjky8mOLUB\\\\\\\\\\\\\\\/UktbVm06Ml6oXH3oM47CL2F4zKw8EPIR5M8E3cVMj+3Geib6PqQ2q83EqL159j+gLykOhbdrjy1GNp815uIDGYome0mj8dIaxnNAv4reIwq2zDP\\\\\\\\\\\\\\\/DyyxMfkJ3lsGlNV8ccCqcIS0vNlv4DbsfJXpPGQMnPivjlUUAas23MuQnrELKzv7CObUncs18ddiLrH4jbK5MNidnxc\\\\\\\\\\\\\\\/iatqGQx86ESR2MmYuXN0huvgsIg=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022cR+HcPOgeBz9YlBWOT0Fzw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00227b0b694aece10a63f09464b4a11699dad53f72cccb22c9f096487e9b96abf702\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e002545.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e002545.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002545\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002545\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002545\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}