{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Gc5IcX1M2j7kSvqKIl9vT6kuGJB3k0MFTFOcxdu+sfR50O+HKxp8PNLqkrh\\\\\\\\\\\\\\\/x+eg0EkxcYrd9K1qBtQlBtk1gUG\\\\\\\\\\\\\\\/hVIdrqRTdpgaeyptr6q8VcwnBCoS3uUOPMB4zwM+6eMcaphi2DVPmsECC3Yl4glewi1xVnh6OavEtqX\\\\\\\\\\\\\\\/ilaY3JiqdLRUesz0gMHme9k1unOCHob7RdhgS+3D8uzJqxkd\\\\\\\\\\\\\\\/EfwkVTYHPlimq80QvbsEiMEZlDA4cBZEgdTqwlhUKIlKk7KKypDDpodg4RI7EE285e60ht6DLPewNMBD42lm5rE2yFEmbDv+m6s06r0EdnYjSWHev\\\\\\\\\\\\\\\/7udyOTthfQjZTDeuvl+EBHiXywy4RGs57by46BIqn+f\\\\\\\\\\\\\\\/JhtFStJqw\\\\\\\\\\\\\\\/RAqQTLEVXBWizulSKNpintHjEK8o6JWZyOc0YerRZhmJa42DQcX2kO6HD0F\\\\\\\\\\\\\\\/LLc0Ry28a53pvJbWbR+FFcxbX4DmQGZpP3RT2zD5mWbkUiEj5iwpFpr\\\\\\\\\\\\\\\/Pgejj4sCTu5mEY5fRSYAxKGkSBkLVYBOzWK67OgmI0JmTlc7buN6tFPeTN65zqcpo6XLuUpkXSVpxMnbqBhlSl47O02YcEhmGg3KXxdm69m39KXW7kELAXqoMvF9U1aVnq9vwx1smXKMZRP\\\\\\\\\\\\\\\/OBs99Ht2cwnScaJCdxTXyQNHPGaBnrN8XHpKAX535q1J74tI3zkihNsUzbnnfgg78FeeEZXOa3wXgJjXKAhJWiH25MTq+dubtgEtvzopVwTWi3Tpw8cuOxJSw+EvQLS\\\\\\\\\\\\\\\/PdJHoxF+nkg27Ol6tj8NXKVpKwIBx4pA4jL0\\\\\\\\\\\\\\\/dRgkPZvZufwQMBmb8L0VhKuovbeXBtqBvk4tSX02+w6SnNJz1agYiL7H\\\\\\\\\\\\\\\/lK+px2XEybFQ5cwbS1lMWwXkQjjsPW7sN5X4TrQ2XpVvVSWo4DiFBYajFnY6\\\\\\\\\\\\\\\/vtPo1YE22ZHMqSVnvzwKBzHX6g19Cbbuxna0FVULrl1CR+kN+FVjSsQXsW\\\\\\\\\\\\\\\/9715aT6nHNz2w\\\\\\\\\\\\\\\/aBUFVSSwCjlXsDcRrw0S3yzLDG\\\\\\\\\\\\\\\/VDMT5LqyLnISbBc4LZvJmQ8VsDXpL7aaqIHHKesB\\\\\\\\\\\\\\\/xaAESq4cq\\\\\\\\\\\\\\\/dFg9WqHIjGn0dggpoM\\\\\\\\\\\\\\\/ILxfMUayIFnvaXBfaBQ18l+dPUkdAWtELy1UEijZ8uW0Fpm7h7bPin+jWh9KQJ6NGzhvCpIZu5wtd72tujvZu\\\\\\\\\\\\\\\/kcmUMB\\\\\\\\\\\\\\\/me1UaSBycPV+XB7XoiPxSHDycm\\\\\\\\\\\\\\\/RP83iEyFUBx2pIvzQy5rywO9EXfFGy\\\\\\\\\\\\\\\/nuBHlKb1AaCizaSAgconuAIL1AfrS5So1c4\\\\\\\\\\\\\\\/Eeqqn4YPAmj7+6v80lpbBw\\\\\\\\\\\\\\\/Iv+dBmn+aAN27EOVsmTcWGX7+1+uAlElchOYf5YRj8BW4xt34EOXlLFoSSY6bkCejoKe8keQPFNl4fGPYPF9PkeqKj9zZWlan98ADjtcsZMA4LmubO9ZOVVJLaedQL5Kk148gg5VATO2tXGqjF35VFzOwWfNV8q97Qlu2IdKzoXj\\\\\\\\\\\\\\\/HnsgsLWHSrLlLd2ha9gbog27FY\\\\\\\\\\\\\\\/A8CNBWOFTXYjXjhN86mX1VxGOAi7GaKQ8VPHHke6esIA8ZHQ9Po+od0rFIv4GWoLRrWL5Sp+pSBsFHxtgVBjQhIYOJElqEelUN3RW7xGy674lBU8DrXqXmf\\\\\\\\\\\\\\\/gUfs7LXs3JKmrNKF0zRJoyIpDVDHBeciINc\\\\\\\\\\\\\\\/qww8zjepb\\\\\\\\\\\\\\\/iz1IjH8nOMob93Ngj2jENefa2cjD00iivuZUZp6m+yYF+HZsPx5KkY3eDjOi3bkhZAzvEWyCAtU\\\\\\\\\\\\\\\/mwg+CyxVXOuMeb2GHKBglptCPD1TZlLcjnZ+95Mem4pnZ8f1kH0TGlycLksOtPVvjBfqk1CddkUX1qhjqo92QP6SuMYUNfSlXzidx\\\\\\\\\\\\\\\/YLOUkSve+o68shAj2WdMUhhu2l7klOVAriBkDSX3xvK3zzORowm984tS3eAyXbSP531\\\\\\\\\\\\\\\/MHwAw+tXLK\\\\\\\\\\\\\\\/KGKxrNT8LRs5DZfgriMPB6T1fBukZUs8i6CBAopmywQ0FI68GP7ToWyj3OO0tVYUEVysGSOnMpn2bMOhPjKD9+NYxhj0xmS9I4j0GOQkjlQ1jsggsIl1GLdi\\\\\\\\\\\\\\\/WvC+I5ioGxr+hLkX\\\\\\\\\\\\\\\/9qbWjYoQvXPhBFipWhxk3Ne28+rmrYW\\\\\\\\\\\\\\\/mTgnSLYN7xiWTg53aUSmZCb\\\\\\\\\\\\\\\/zithqVs6WG\\\\\\\\\\\\\\\/wEFIvcGZZY4Fk\\\\\\\\\\\\\\\/zn3zn1q2f2pCjhAT4\\\\\\\\\\\\\\\/2EwFvpnv1Dh6Gcx3\\\\\\\\\\\\\\\/enz46s+4Y0J+67dwtjXqCpg+eGKn\\\\\\\\\\\\\\\/aiMQ1WjZ07FeuXDGPBItztyKhixyVqcZwQhgU6L1QyWnDLGDQzwk7veiAYPq0iv1rLIPdZCM1m5H\\\\\\\\\\\\\\\/fkXAdlTGuE4YcTTnZP2CmwTC\\\\\\\\\\\\\\\/Mg37gfNJvSgmp08+rI0A8TNGvz4yoOg9UPpKGvp70AU\\\\\\\\\\\\\\\/w0pg9CTXc+SEl5duXx6e1kwJZLwptB3MR7jvVT7nTTUc1kRdFnEIti3lpd9cEa\\\\\\\\\\\\\\\/9z8uPXiBiWrn4wAQG4QQVglwRbRvfBu5WQfVefugrm7r5sLIOf55uGkZAUUXm6ZSU9AH4RE4vxB4tvQPou8Zik\\\\\\\\\\\\\\\/NcDgx+VFkq\\\\\\\\\\\\\\\/L4WB\\\\\\\\\\\\\\\/TrcYL543quIa4lt1AJqmA7cVxzfDWj6FbkWMPG7gkJpSaEmF0igPqGzIAFdAguN8oLkHYpviOc6wQ=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022W3cj9ZO8FtkZt\\\\\\\\\\\\\\\/38tiPqVQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00225d4999c1ae4868e9c52a5118c759991962cb74e58abcb6005037b34a2db874b5\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e003499.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e003499.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003499\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003499\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003499\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}