{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Q0od7RxwuEILIbUFlIx9fmv0n\\\\\\\\\\\\\\\/ucVqiPGHFo8Q28xWk\\\\\\\\\\\\\\\/zFD6fNzBnKIRSOkfH0JDFw6USdIBPDMhC\\\\\\\\\\\\\\\/1gWk4T1gQ1mbpX\\\\\\\\\\\\\\\/aZR0d9qlCgG7yZkx7+yM8TDGwd4QK2iZi7QudgUHxhjyRc1NwKkM6+2FQUFcRCAywemG8HesF1QqHvuUxz\\\\\\\\\\\\\\\/w8BlbEhWyZBAo0rc5JuNTF+kmqn4xoX9SdlF+qclJ0LtkBlyxY3B1QedfjNQLpPqHNgcsG6WDbyXjOi+JkKNZvqeCShkYOWIO9KTSL6MQ09lKkR0j\\\\\\\\\\\\\\\/JdDYa4sO8NWpwBSdql4pN5AgAMGPR4REa3+r7UUo5rr+bkjO643e8zGhcB2VrwKok8kAZoTjgdBGY\\\\\\\\\\\\\\\/UmgMjpIzQcIN2JjkicQbInT6JQWCMY5pV+ktIU7fsKL+k1AkRge9In0AHkkiPe44G29SlY87qeJTNcEpWRVh2jLOrfHooRU+YTyIXw6Z2WLCwsgNgINXnf29XlAo4Kyyu77MTnEkM2i7+SWAQ3WERd+Dr41JsM7\\\\\\\\\\\\\\\/ixLoTQ4VhIFvX0MImJSlcYh+iDtJXf+zxwdqlwoDc36E0k3XdmfjXJCUTvBmdRwPQplCtC4NaVkz8e6V4\\\\\\\\\\\\\\\/hc30ilTCJlrbQvgGWlfhWvKzbhu23N2XPNB1kx9UKZJdb4aNHhfRijMMwj6hGs1JtvIPSTs6RjmnTcHHGE06w5sElvgQdP6u0uOeDWBju4rAh4s4B2Mq7jdUHtiYL4nPze5hxAnYZezjDlmhsl7nTscEd6rzzmB2241Y5fmYOVxBq+p5pX9SAlm93X4mz4aK1PHxpuYI2G6ykFQDJBWjI1v0SrIZ6doD3TPD6ueJMAlPN4icu3MKNc10yIShDFxtxC5qMJdwydCUCV2pL06PFyinxPOQE5S+yTaEltnQTpcPaUIpiEw6PZ9xYe3dlNhuJVSWW\\\\\\\\\\\\\\\/3njKoOyAni6W8xZFuJ4MLI3wL+BOAMGQ\\\\\\\\\\\\\\\/AVzm1MLT5iL2tGWI+9qiD+kKYPw5eYfszQNC5yO3AxyExek1M\\\\\\\\\\\\\\\/QpYDvv\\\\\\\\\\\\\\\/X\\\\\\\\\\\\\\\/1wm+0dG2wxLV764FPQR8Z+z6wrb0oizhTW9\\\\\\\\\\\\\\\/JC0Dh3cF\\\\\\\\\\\\\\\/WVcHgG8hr82weFNtYdX0FqCkn5ZorAqPdOPndeVaHHAViIzwRnf+Z1+d8XF2ACZSOASwuLZ8LxKJBhYp1Mvkw0DUHQYGNGuptt9Fq5YT1j0nq3dI0NPhw31bYsVW741EHhZ6c4qmo0ZRKbVEkwGKOmvjwxMwd7gPq0U\\\\\\\\\\\\\\\/gPf1RUw28VQRCY1O+ojMz19f8rbPE3niuf6nlaOCs72d+oDNGi81u9o+NBZHxngnGxUoJMvn9NywnuC94LHsZvRP+fvSlbVOWdzLRE5lgKIdQkFytR0KNyU324qed5GjOfZk4tXQCWBDwziWhclxcib3AwCNkQ1obzbAfFcYAoSO4xzOHgXhY85hoUpD2Pcezkx0i5Bqvlb2KkbR2nJH9PRPzk4+5qXyP4IH5OdIoimrE6f6SBT52FnMnGsEpURFCLKitNUd5M\\\\\\\\\\\\\\\/h+oi7Tn16GQEmyo5YE0UyCpfM+Ojf3q7uLRkCL1QhFe5LybjefeeeNhL9Se8T0OagR7O5RmH+FGq3v3mIZSID9nHqLcZ1IzYGdADeNG+h\\\\\\\\\\\\\\\/7Q2+UrrARgmI7WncDNbbM9END+MGKWVOik4hkcSL95kkNV3ba8f9iD3kKSDjqglICF+mgPAQD6oUYP4wq5DeJ0M2hikAoHpchSVz4F2VAhzlo70\\\\\\\\\\\\\\\/t3lIozLBoEzZZ7ZlKQJ4TYSCGWZ39ePX7ZiGZ83aLAt6Bqv1t+jMyXwV1dVed5vnoeRdygd+zLV\\\\\\\\\\\\\\\/cgegpPadvwKUu\\\\\\\\\\\\\\\/G1gPcCawz9aGvUJa7T8+iB\\\\\\\\\\\\\\\/w1kv7AjklCACRDJe2DeNL1GKwKZknOBk5XO0be4sTZ0OOgZ+GEsqpE4mwZ7tal7\\\\\\\\\\\\\\\/ABuBzPhgUrn52RKao1VxWs3hDDiirCyLMTUvXoZc9xhdplwx6CAD1Uj3XBkE0XWVplt0n\\\\\\\\\\\\\\\/YMsBGiA4xpnosrNI8uAcqAA7SUFIF3lp0FDByV0oqY1nWnnu0pUNCY8sW5pFhPWT7CZCsMssJSqabZq42+I9m08CNbMZwL9cqbmojEHQ8LGruVh6WCrP4x+DGiRlMwCVbQb7Gx0iYizcJWWw\\\\\\\\\\\\\\\/81cznGRO\\\\\\\\\\\\\\\/uf3Ufv\\\\\\\\\\\\\\\/gBaiukB3hQTOrHE28JeM1Tjg4nRdMMQ9YfC0cMy31FZ7jceIn9SBvGsClXg7wrfgd4i8vwivn4Zq0D7x6KUFm0ODR2rHkt3h+XZ84wtIEhHFWiX\\\\\\\\\\\\\\\/CJNFCAFdiB84r3O6ktv8IG7TMlkgE6BLpxiWHGEZfQyoXzVISLKe08keZtG6fGTUDI4as7U+IOOE29UgfCPCfYAIa14tSHTSdfhpQFVUriOpPyH2Q8IzWp70gIgwDGv8QhOb7hU4ESs5Z\\\\\\\\\\\\\\\/qU1aV9AdwGG9t9K0es32gpaZL\\\\\\\\\\\\\\\/YbleY6TIcy5l33MdT9i+G3jfNzPn58sDZwNVivRTaXrwtv6WfVWg489xB+MwFGtrqQouJLzTzQUiBzX4xHzVGqqWFfKv+ZlG12e3GCBVqksLOPI3y1QQgu7NPOxERT1bMZfTBvlmoJ27AAeb6smIX+votupglsw3AcPpqsLYaatRhIupPug6BAawy6YYV7Qjw=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022q\\\\\\\\\\\\\\\/Hw1NAWXzr0WkNkJfFoZg==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002218b03d54663791aee77c647f513cbd007358f62ca9b72b15e45473e7380b4aed\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/10\\\/e002955.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/10\\\/e002955.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002955\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002955\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002955\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}