{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_KRnV2j6OaoIIxt76AbJVZT143yroXCg9nJWC5fgbkZM.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Q3yAUypds7piagMBd+MRY6T7yQ0UP+rYhMYFGGPw+YjqXMfUcQoTznLrGD8jUjCM4M+viofQ0ERpY4belsDFbKykRcYwBKC7z6Sj8u\\\\\\\\\\\\\\\/I3wGTNm9B7hcurunG1VHFRaQkEVojd27FhBb7fuhiJrRGbu7auRB7JeQ7WdjDijHqAJUs4GBaCZ+TF3jsCwcXCVOaRmD0Vv7gAlk7KfugThmdR8Tz\\\\\\\\\\\\\\\/nHPYkJx9eMVJ1W5JYwZhqNHpHx7wHb6+SRgDIY\\\\\\\\\\\\\\\/19ON5uUHNRQsMadyMWUHvYSKu8o6mJ1XN2TjF\\\\\\\\\\\\\\\/PnGYLxuPEVqehV8uoWJBujut\\\\\\\\\\\\\\\/pR2JbUJX8sJaa86izcrdS3ABbelbp47PU27Yfc04KcQGq\\\\\\\\\\\\\\\/yZDBYyYxk9OsuMRsuLgGpo9b7jKIIA3Lbg4PhS2mvHuHKivXjWQRoPVD\\\\\\\\\\\\\\\/H\\\\\\\\\\\\\\\/zgDuj02SVIKnBKgtwXUnTfY4KdYMH9YnEG9gimIJBU9NEk8bp\\\\\\\\\\\\\\\/0HbK6dWEUYz9bIxApQh08qakZxIcFgvBDmTVpNKM0ZT3\\\\\\\\\\\\\\\/pK5ErdkIpm4pEdnHMVJvyIiocSpt9Q\\\\\\\\\\\\\\\/IiDIIPMf+RoTaPJNC4Hsycjf\\\\\\\\\\\\\\\/07H+Ehfjh\\\\\\\\\\\\\\\/kQXq5ExP63I0QTaIb76+aateWoa36fKxiRXjyWFKO1hdT7tLEVwwc08MhrAKBAHCUlrckGh5NRT0R\\\\\\\\\\\\\\\/H4kA+JhPL8fTAipm4tVOh6CbCabAoVBEmsIgFfHaAPJgNMAqagL9Gxa\\\\\\\\\\\\\\\/TWOB5yDOOAy5cfOr4jxZRJOjO00p5nB0JXY8\\\\\\\\\\\\\\\/ZEKC48C6hf5Ed9GDFwsml9cBKKzepljHx7dkl+o113vYmjejgiGKGu\\\\\\\\\\\\\\\/0Gs2Bch2LM6P02Wsjw5nlqtPdFk6L7w7f8GhU5t8x1GMVPLsKCBuLXnuZ9wV7Kl2z\\\\\\\\\\\\\\\/2PHbcCWu0B0zLaSRFXF5zN4ynfFFpqcyuvxASD6IoC2QDMQovPrbvk0eZ1vo+URmLWjzrfjVWkoWmcD7\\\\\\\\\\\\\\\/e0dUMtGDJNw9DQOq5Z5muE60eDKq37ZQhB5p67uJrMTYmtZaVSf50i1+oO7vbCemCIHZfWpUbcpsr8L4aUj2HDnGs\\\\\\\\\\\\\\\/AH88KAcukTQRhx5Ox7v\\\\\\\\\\\\\\\/eP0uNyyROb19yVXAOfp4DjJrQ4VXapXFbs0R3iJWun+pgoTU3CuhNkcOrXuj7RqcMkCm8PmYv2OdykV7j6WtYlRqIVi2IjK8Q\\\\\\\\\\\\\\\/qM5T5sWN9joO6sPj1w\\\\\\\\\\\\\\\/Mx8P4V6\\\\\\\\\\\\\\\/g8p3F0f1CO6O5WgYiZhoCc7rzOpFQ16p9i8l\\\\\\\\\\\\\\\/V4dny06knpSBxO4N1ZbFyrESCwav2cTZBYMwDPUIjJ0MDY+Dbpa4GZxt0kSl0BvUl0n6zP9Jl5A4BnV3h736oIkN++\\\\\\\\\\\\\\\/gBpvpB145RSoB9LbSQKF13hppITBqvWQMvSWIvAQPQu\\\\\\\\\\\\\\\/MMbnWFcg57SxhLlJuBDFcHaZpKeSPV57VMRTLbsWwz23GFG9bnl1392RuVE1Gvu6PmN9dn2sfhXdjIiQ+HXgXz59mo5SVkkTRP974k8UaEJXYJLzlj+x4hSOTGW9cDf0TFcuFYRVJlPvjcHVYVRFpkS9im\\\\\\\\\\\\\\\/wX8222UOE1g1tZY2DqmbZS3tETz1spRPKioGVoNkuDY0S6kk70KHPncWV33hzOAMx4zKiyITjRvtRmUKBIkTckv7ST7fIXnhTPLE1FJl5KIQB2dCwo3y635RvgAU9uHzGbIRJQghW1rCN3EZpKZW8aIL\\\\\\\\\\\\\\\/3bywHA53ei3dAWS8aE9+p1p2zxUINoAacJhAJtIo4xUpcNXHeTSAsj6vk5AjzyMcV\\\\\\\\\\\\\\\/VwkkWODkBfSOFrZbUa0mfBii8TxMglO\\\\\\\\\\\\\\\/K9LOUhXp5l3xWtzz3DBL3PXMAuS3fAMJjT3MCyxglQw1KNzvHm2mTvUyW2PB9rlLtslPv69UkJ3XQZwFFYbAbRdfr3Sj2a9oJvIsBvY1a0QWKPi73lOJ79xf+9aqdsQsW7gfnC6VOTfFRjwJ3pRlbU58\\\\\\\\\\\\\\\/jC7OKd79a5MiJzyOk6O6UoCk1ShQfLKaU5ZQI5XHTXlX1TFvT\\\\\\\\\\\\\\\/nyv39eAFEeJd\\\\\\\\\\\\\\\/NRGnGlAlnVsvRV83sf5tc5DKGmjhfO1U3MwozLPo7NN2fWk07Yi3nfAFvJg6HzGRMhLye61bSlRy7TSjVseJrD8\\\\\\\\\\\\\\\/+5HXtbLEdQVODSROGbYTG4ovnp89J7BoYdnZ5IBH1QuVsKRSeuyds4x\\\\\\\\\\\\\\\/b8\\\\\\\\\\\\\\\/z2GcsjawB4ghTOh\\\\\\\\\\\\\\\/tFRD3q6Xcp4yK9xJu3jRf2fi8LfgoXwBjDf3gsZ0d4cAzmI+5lRdJQGIrJSzL2gdAiSGSDqCOypDVsFwXdoOOgEWN8hyNbAlCGqu3koYmeQiigKmhB\\\\\\\\\\\\\\\/22VmZBhKSpx+cxxQCowquGSpF2VjFkiKfhneQ4S3AhWqjX9MTfTi4fZwUhqMwUy9epLY9KSjW3IQC0tD61atR5DQ29eChhaCUvK\\\\\\\\\\\\\\\/cAr06fz5f3F3tljYhH+F2fNi4LWaVKw\\\\\\\\\\\\\\\/qYI27NB2jA5o\\\\\\\\\\\\\\\/UTqcHUnaFBctPWhgjK2OV4bWwoSX1W4wWlbnUDO2QrwIiZanxIKcE3A2SxN7keR4\\\\\\\\\\\\\\\/M7FozPNwq17xkHkuza5xa5cM9NLXP9XHBkqJyY+a2MsDe+wXfrxJEQOuGvqhtkhZz5oLFRAnUFu4BxFytnLvk+U343\\\\\\\\\\\\\\\/RIu9SmWxlOsG3UAPwh+hNEZ5OP7MgFp2IH5Lc=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022C7Acz3N0wxHmARykysW\\\\\\\\\\\\\\\/ow==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u0022f346fad080c54d0a900a3d30e5730f758e62c934abeb071807bbdd74e8456011\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/9\\\/1.3.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/9\\\/1.3.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}},\u0022markup\u0022:[{\u0022requested\u0022:\u0022abstract\u0022,\u0022variant\u0022:\u0022pdf-extract\u0022,\u0022view\u0022:null,\u0022pisa\u0022:\u0022jitc;9\\\/9\\\/1-b\u0022}]},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/js\\\/highwire.javascript.pdf_extract.js\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__aRHiqc_vICBvSio4EV9yK5gvHQhdLEYqGbyBpwrSoaw__yvqPgQIYe_eVyaoH2Vmp1uUxhQZL69H1fOXqYIpbw-c__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-markup abstract-with-bc\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022highwire-markup\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003000corr1\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003000corr1\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003000corr1\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}