{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022EpObbGtUNCZAneGniV6bK44AUn4JoN46I3r6XfmhsQpy1OcoU7SZNa+Dv41FUA32t2etV8fhC419HLAs\\\\\\\\\\\\\\\/yRhDJfJjJdKO+RHs4HbgqPBQViz6HfebMG\\\\\\\\\\\\\\\/3lCQtzzaH+XzWEw8DPF9nFurgiBmZW1MwDiFEOkpYqtEAB4LIo7PHMSU9GtNaZh0rKfHrMMBMnzHgJh4od8kuumbfat5JshLQQb4ZZv3H7M1ng4YF9rILxMvj6+dv4QYBHUoQDLYUjZuBrOWqFSWdrIwBBFBGzSfA1cg6FS0q0+zvNNdXnphJAvljp\\\\\\\\\\\\\\\/JLVm6Fkjn1IEtX3nDhsmGJwIEwBnBRFvWp1Gzrfa1Gx15xIc0\\\\\\\\\\\\\\\/B4MSA0SC3Hkt16nAwig+rgNqcd44uWkQrPtwdxtChD7bj0XnefmPmYZAEXza\\\\\\\\\\\\\\\/BIxo72Ce6172Z1tz++giWv6jHgBfE82nY2Tc+bb5NuKkaXglMKiyFr8+P8NJLXkijWIZ77WXGQI8d\\\\\\\\\\\\\\\/9qRylbJdZqmBlYg79H6iG8iQ8YcF5\\\\\\\\\\\\\\\/53691WU5pV1FY\\\\\\\\\\\\\\\/QFhmMhGSXa1K4O9IjVW5C7CqILH9dySHKllz85\\\\\\\\\\\\\\\/8kK8GceItZ3Lq0HxEZBLw4G0+op0bZheBAZStD8g0nZwq5X0DXNt5Juofh5uTXwDjJ37Eda3Em3wUllL27GJN+pFHppRFhrwf43H1SBkhfq6UcX5hu\\\\\\\\\\\\\\\/S5TO\\\\\\\\\\\\\\\/lhBzemOyh7OcZa5pwCIK8YaJIa+UVhxJmEKKeaLjpSdYlzZh+Ul9sg+x7qD+d5LlEm15Lf8pmGte\\\\\\\\\\\\\\\/aeuaEurPWpgnIURqGgIYIQEZmsfcRfA4fNLkVDtaEuZ+Znx8Fy7pyR4RxOguXqFj+9+bDYjUfn7cqF6UN5fc+33yNmzHFduUi33aCgVK41k8UW\\\\\\\\\\\\\\\/CwxY+h68GaQC5uubweBAZPV4X6l5ZT3pwUKuEprhjbeRSXoYNTOXMNK5qg6dWoorSmrRxuBCBm0VLtk+kuKOtIYJuIZR8MeBHoQSfoLHE8lKycOmO1PX1NW41jtU\\\\\\\\\\\\\\\/Hqo8yJrBup\\\\\\\\\\\\\\\/S+Q3Mo6xP3CrY16TbYhzPUgFoH4ZXaSJd7Oa0uFxdG35Sby+Rb0vI7pzYbmO0N27WYtO0WFnOtYpioTmy6MaSzTbtfzaYIeEVBx678wfrIw0Ha2lprFQFJGI9KeW7sbGIszBUyYOmAj+mTEdyVpoRbMVoH9NmGDzZ1S2Ystls4S04bUqcPkVCfTbjRV93LDC4of8mzhqYFvTSt0pi\\\\\\\\\\\\\\\/enqFz2QgdQbPSA9IvDXidGOPR4eEfL1ETFfbbjViiKF7VwNVZ9EEjukL8aR\\\\\\\\\\\\\\\/87pmx0QMCfveG0xkdr0CEMFjakpLU5A3H8nPF1Hk\\\\\\\\\\\\\\\/KZJTVwaBgGoCgp7fzRg\\\\\\\\\\\\\\\/tJ0w1ZRa48IAzq0md9X+DspkQlikoNhVVu6PToqHTHondN\\\\\\\\\\\\\\\/jtIY1T7N2J39EW4H4pD8eyD33HoRrcbpkx2pnMMVH11WVUwGsp8tgfVEh\\\\\\\\\\\\\\\/G\\\\\\\\\\\\\\\/RviQeTHXGdPxU5aJfaGX1NAMOzT52jHu1EcKQPf3YUfr+P3\\\\\\\\\\\\\\\/coVWyYD4pKdzbWptc6jElRNA+NwPDSPZiQXuRoPTFQC5+wYy+MmtgO+SiyPC4qqmfzJPgKTizdXzrxS6YfxNr9AV4DIbXo+SE385NfISAE00lVY2A6fBqktYkFl6OrSJTVbaame41mk+SKUBTMJZcl8usRuH7dVoNb9XnaVglWwqb5gWgnYBSy8KkaiK1CsODvTDyrpnjDj66BB5WqveMGWiUINeh7PVgvpQ1r1FY9magqeq5Y++RtADCikM6lP6u3hRyfLoYr41e7WodoSIJRy\\\\\\\\\\\\\\\/g2KXJazaonee6otdrH\\\\\\\\\\\\\\\/f2n5wWa95pBA1vGSoM2K3cmZY9e12OYRL+Oesz+I0Io4kXukEDToQVfSyGagHXPXCzSgp+exdcROB+htgjACxB10ub9x22HCnmO6DNXqmWWTfDVEbSX1yw8qbN3G8cryMdL3OP8gH0sun3DRNdl62F6uc4dM\\\\\\\\\\\\\\\/O8XlIH7g0cVUFaxuvZ8JCzqTTNdOzDnlrrAghsis8hZw9WpaMMAZwA+H+DQmmf9d0AqJfm+rPiWllsod7e2Xo3tfTr2pt2xh8wvV80kLcaa62TY0iBauctzNPAUa2Mr9GY3tRCnZ5tU54qfsaLEe\\\\\\\\\\\\\\\/A+EFKxZnXr3daNO6c8rl0HA9+89Fd5JHJWxUH5dMS1\\\\\\\\\\\\\\\/ToSLFQYm68VAwl7je8jiLOwbhrK7YPbnqSklk65fpLLNPHbeRJWX6cowYy2BNUsQ2zDqgYr4RvKAxA\\\\\\\\\\\\\\\/zMe89nY+4cZfHdrF1wXnT0tHuMqCPmy0LacPO1lm0OLSDGbVKJB9Yk\\\\\\\\\\\\\\\/M\\\\\\\\\\\\\\\/HI1dAeLEXqwvH\\\\\\\\\\\\\\\/rWp56m3h51kqiV70SwvNZOM9V\\\\\\\\\\\\\\\/2Xe52EqeKU\\\\\\\\\\\\\\\/BqQuph64BEUMBgg62fgORCBacP+2oGUn3jDcasN6mJeZ0UdGB9npXF7RgejJFEj8hLpVtuTUdGo4pN6Ha6Q+9bVsdoWdd5\\\\\\\\\\\\\\\/yoDft42GsiExXPBg4Er0PsRYaBNJkfa1GPp7hKL41ENGYuEPh3cNCCLsRFJlmQxTa4XS5nq35NYSXGzPyeOWraAaTqkpnpJ4\\\\\\\\\\\\\\\/gJ7yzEOAZ54s\\\\\\\\\\\\\\\/B8jFSSIqH7MoUP1roLEPxSNM5PEnqnnMicwkIJ3IuEkfj5jwKwKxDi032U=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u00229oi4XZK3D914r9CebkfVXA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00229141eb17cc1e46d6d85cb7b34e700f6b20751eb5f5641429a8d2ea15539e61dc\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e003113.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e003113.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003113\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003113\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003113\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first\u0022\u003E\n\u003Cli class=\u0022last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}