{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022Em\\\\\\\\\\\\\\\/idTkWoCYseoPrmTuyNE9X\\\\\\\\\\\\\\\/YaaAWQosvM6CZSNLWYZm5xXAt2eK4axo+BUD\\\\\\\\\\\\\\\/5ZVw+WP5bkMYCbJkAFweLfiKnX+0ixF9YdpvITQUbSc0aM8ZHkE7AWSj8uHkj7QnFSJ7ZihcgxrXbbbwfUj2aCiRy8jDno36AbZZmdQX1Nyl+8qMc4HmI8zetbyPN6DpTA8jsRN5ou5KJCG49Jn5n1vzelmrTslzJnvq43qmDLMZnAUBjuu8tgl0e9OdKWE3WBGqVnPuhCUnqfP3Ed0ZOfVQuJrOYRlCBtWv09qwBVNR0fgGqYxqJev+LYtgPZLPImyuNx5NFE9YlzNqRocOw2JupBSGM6aIJgv1\\\\\\\\\\\\\\\/ODmfnv2gOFa5y\\\\\\\\\\\\\\\/vLJInMDveGmUfFAviswQsK3S9TUGxw9zYNJ8FpFWcRWr+s26ihPX0yY2sC\\\\\\\\\\\\\\\/KPB9P5Cz3oczVN4yWY50y\\\\\\\\\\\\\\\/Q49ZQm+vWPS4qWXfhG\\\\\\\\\\\\\\\/rxrD2IQpbMhy6Wv6ZB6fJ8H71WPvtxbtxnWEEDX2yQRiX4AOeYFNT6bHmh7ME3\\\\\\\\\\\\\\\/tknQXKBkIJ3r4olbUhqJ0T+wHOOkPANZKAGamDybPjnE9B5T84J5CbYHPBNfu8WXKST0rftWFVbeRs0PpbLYmuXf9HhhpxJuu7TYi+F5Er7E+OMN9ce2odFXV9jECqkDUjCzNxAVEtW0ECZkx2sYde4drPeij1njY11j71Tv+4LypKA7S\\\\\\\\\\\\\\\/e\\\\\\\\\\\\\\\/nmQJM4CMtPU+lXpYBgG+4zXihCUe8ztenZ5uJpeXIiA\\\\\\\\\\\\\\\/Ak2YEOWif6py2d0RZydC3HAF3JVeVItUOx76XZtEKFNJgWZxP9mg5iyAE2LJDbj0M\\\\\\\\\\\\\\\/8WQWXwLTmlDunEHw\\\\\\\\\\\\\\\/XAjjrX7df80KFZtn9NsGsWHEzZTOwcbpVZo02gyUIKUV6xiG2hA5qMo9fWM7Q6IMLt3JN7LKmPSP\\\\\\\\\\\\\\\/eVuAX2TrZWVWx6Jfvr1CJloikA70teREMrqL1zmlV6arl1GddBADUZShCHTUSakydMqXti7HVqQdyGeKb1zlnTBjs+Cm9VT6yf7LqnXgudYKCjPWRPcD3Rifa3CMopVr+V2Yyc8Gz1+abQrFiLjU2VVIhzhSWdLILQm1r\\\\\\\\\\\\\\\/vcPgg+Jq4mF6WK5Km7CTW4\\\\\\\\\\\\\\\/jmQdJG2MRuD\\\\\\\\\\\\\\\/K0Fcihk74saAJr1zdkd6CYEBV4nG4CUpBQLqzbP478hqgNxKrY\\\\\\\\\\\\\\\/jF3TCJTAp5qXlBMY7lcwN7Nob1PJnQw49SO7rq9ZtT4wBO7NR4YL06vJK7WCfPA0k4P27KrfODfFOqUc5ajbC\\\\\\\\\\\\\\\/30Rj2M7+kDEttWzs1uTp2xy1\\\\\\\\\\\\\\\/xPeTBQUzowhxG2sY5EKaxKOdFUlJcopwoGowdgukRmcWHNLIp7tuAaZNf76KTLH6wZ1DvSQIxDzE\\\\\\\\\\\\\\\/Atr2pe1JzOJTjRB0OO\\\\\\\\\\\\\\\/IHmzuj8RMC+gj8+HU7DnPyjD8IDdxLv7s7crIoYOojk0r25QVszUqvPjOzqaoERhSF6iqyejkepFAOLs0aHxiRtNgQQcoVjLny7shgJxBe2uf5oB4ua5Dr7BfC6nxcCXhqTdo\\\\\\\\\\\\\\\/mZmP2\\\\\\\\\\\\\\\/9LglXyutF9XOlCvp6F7koz1OICVKt9x4CB1wCTP+NMlGtJ+AQuaJ7uNeeErmQIEZfzGZrfaV6xnUVKiKKVVa77tSFwnI8g9RLCnXPO+\\\\\\\\\\\\\\\/Q1416\\\\\\\\\\\\\\\/yp\\\\\\\\\\\\\\\/7ea0s1Y8XRTU2GRZ0kTiGJuDxecSKtphjzeJtq5FuDyxY54UO5VqWo+i2qR1E9PUfS90k4YTvS7izluFzrqt7QguE\\\\\\\\\\\\\\\/38xtPnzNWCsS0a3BT2eiKUo\\\\\\\\\\\\\\\/PutfewAq\\\\\\\\\\\\\\\/+GnRMH6JqgrYgwhsBSDa5JeCU1peL28fSUkRwA77EzsPPxrwLDe6SM0tC\\\\\\\\\\\\\\\/vZXqVSN7G\\\\\\\\\\\\\\\/fme28jTNubDMMCckpbx3Eylkun18hU40AeAxlp3xc\\\\\\\\\\\\\\\/ZLVhdTIdq2r89ImoqGEcqR8v\\\\\\\\\\\\\\\/sSHev8evVB4FA+GNy9OOv0IIZlJExDz\\\\\\\\\\\\\\\/MA0U3jwI2h23b45giPJlmie7uizg3NktM5OoS6qFV6qzEQwjasWLAL8IkWP1egvgK\\\\\\\\\\\\\\\/OJfmao92IQETPASh\\\\\\\\\\\\\\\/GKtlwM5BSykAGw\\\\\\\\\\\\\\\/2rJa0d4JeKOQGS5Ys\\\\\\\\\\\\\\\/k9DAWpuURjX9hF5uOHZLdHGGLFUl8SeqnfyV1BBKJpPpObsMqxHxVYQ+PdYq3J5f0DgDyHOKgtGKnoHKt2SloDrnfJkXCSe2MDxSNcb3xDhNoheoWww2DKwrUn7+2utcG8Pe9QqIuYaqmngEldU54NA6R++U0UuILrVYLxeWPxlZMTK15iwFLD42Ch5AhzuclE3wfGPbWFWgrIxK5mJHgB\\\\\\\\\\\\\\\/Ah8z9VaRLcuqNfpkF+qXEdShJtwr6hKPerPZIZH3sdVXrFy9Ee7lROlZsswh73Yh1Mt9vvDaxK6gn1ANnK+WA8uSw541+NMBfGwc+OuL0jLu\\\\\\\\\\\\\\\/zLpqrEsrZWaXM6wsICDkAtS2Yq\\\\\\\\\\\\\\\/4xpg7dwi8BWu5kWAz5i8TVavBoHsZpeA4ZqMAfZFyRQZ2wdGnhcNYbfmkI7EP7YjqE1VWT478VrcS7zi5NnNJV0YzClxg0BgBPd53tKjVZOTCsuHJtI4hjETx9Xzfhur7P62cccxh51UHpV5dWNFWaalZRDQ74zvIccjCD4jHh46oKCfrp\\\\\\\\\\\\\\\/h2++cdlqyQ55+23ATJR0+2i38DlzvkzZQyXe1hs=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022onT9udSO34oz7vq17XF\\\\\\\\\\\\\\\/vQ==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00224679d8f50830adf41ab7448ec1f80aaeb0a07be04407c58d871f9082a4187070\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e002804.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e002804.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002804\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002804\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002804\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}