{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022jzCD0tZ+EdjIGivLG1FMdea2LBWXX1BTMcKbDoY6hk1mjsvlKA8VzVcsn5mh\\\\\\\\\\\\\\\/RNbQl4v0B0l\\\\\\\\\\\\\\\/c7OhHxzOTh1\\\\\\\\\\\\\\\/4G4XGvqHttcmWXJ7bJAp21j\\\\\\\\\\\\\\\/RL8IISWAnEdsyiqte3rA9i+0+RIcl6tanlVKi53JDiiFhgfgNOYvq5EjTH5Fu0TJlmLQ\\\\\\\\\\\\\\\/CJalTuHdLKP9ktr57pPO7lU8RudiDU62Vrb7yWrIrNCdx2xdtzqV+bw4HjuQJyZhiKsOX0LTozvuJ9AE2PsE4tY3bN\\\\\\\\\\\\\\\/ejPy6\\\\\\\\\\\\\\\/goQsK4DKKOY2\\\\\\\\\\\\\\\/NuVyQm0lRYIrDRN\\\\\\\\\\\\\\\/3gp6Xin+AME9qd9lEJk8E7A08Ebzcj9kYYKf5HP\\\\\\\\\\\\\\\/Y2kjr1g4mUyTxHucUHxd58iTmpByESdtCC4UvpwDMRcJHh6X32w9OdSPx8NRtmecBAaFLf+\\\\\\\\\\\\\\\/A8CjRI5UfQEPiMMgwtr3vpQf0q9Da0FXXGDUxJH2kmIq+Aqnq64AC1fhos0bJQHn\\\\\\\\\\\\\\\/YU05Fbh21pze6GFLDsPd1Wjl3OkhrfzLKovJdTqhbDesxFt2ZFV+VGIfgFvAkdLf5AvvVK1v4keoUKPuCyyL93i1uOxgHcwygyyeCP1oZXP9+Y6X6oozd0v\\\\\\\\\\\\\\\/vFYfh5RKFcpbBieNMBRdV\\\\\\\\\\\\\\\/fUscxsNJ0KaukyoRNGvsCd0vxT1mQnglXse52PqBAwltuDPzr2sfPNSfbVipiadjwGoQ5k+SMbwtp5Ls5pfSs1b+NjjxGOcbyWiW5ACDUVIoWBeSRTZBVM8VDyx9HKVr34JNjOXtqvCALkI5BmXx6Mgw0R5QoZ6Wm7yyt1aMYTufVsSZPG\\\\\\\\\\\\\\\/GQcoI9e8VMlYCSicCRUtv2a5sj6iYpxHSpaugdh1BAt+EXCcOHA82LkKGyv5Uzdzre0g3sV0\\\\\\\\\\\\\\\/UqxUCxs7rva3oeoNyU8s4+qBeUUDkEChy39en2dJ0gjL0nT6UqH3H4CImvyaXtOfE1E8LAcoDrOMjQyP3BXy\\\\\\\\\\\\\\\/YdrldUhmGbPeHVIRxsFzM1mKevOXy4uUzXspoKDToXvKW0JBD74tvw9SNFnJN6EqI2oqcgP4j+QOqp\\\\\\\\\\\\\\\/UVXUX1erTa5reSt39Mj4oRV8L\\\\\\\\\\\\\\\/GpZTcfH94aq3IWmipdRbiyODkeiCs5WfdvFgq03CU\\\\\\\\\\\\\\\/B8Y4H1hZVioUc\\\\\\\\\\\\\\\/hs\\\\\\\\\\\\\\\/j3kWq9l6GH1\\\\\\\\\\\\\\\/I4Xr6JnQpE6hDP94p+yyQ+Yzm+PKrq78ehMm71oY2eRK7u3dqy7VobiKrjBy5bi1nhydLUaphaM9qTTrifnzvfCse1QdyHZHMlQFtVoAFbAgfpWqH0TUge4pRY4RX5K8cTS8BCe9qq2QXzbPxfWCgBuCPw3wipGUnCGCvMGcvHCIQKCPVbcChhqUZAP5ZeDKDJELjZ\\\\\\\\\\\\\\\/mat2g02PHIt9nua\\\\\\\\\\\\\\\/FcclPyQzlth3KFbUUP5KBIQ1hzqsZGjz\\\\\\\\\\\\\\\/caQncN6dUyB+TbnEQNdunM2+WOfCn6Aj9xLGmS62\\\\\\\\\\\\\\\/NWtJbuF9YnCT8GK6\\\\\\\\\\\\\\\/66l2giCE53k5aOJ94R8Ml7BNQc8KdcycSAXSxmA4T89E9Jq5saJ7HtUSe+Xwh4YxsCJVgSXLoeOrGYbHGevhK8PVCKhxd\\\\\\\\\\\\\\\/9OxeoL9q3n6XNi96gPNNKWg9tWdeATV3gkP8Z7Tn20hDdma1v5dXsh3bh5GOxc1dFS8mwiwhMNdi4PlQfTqh2fp5YZbu0TeEkzjjkQ5d4dtPZ4dufNQrrYSTjBMQFMyQne1U5k24+HlVflZmcFEcU4V6NXm5kbac6KC6DZYQFQr4DR6dUH9pGHhbt6\\\\\\\\\\\\\\\/dg0abWHT5n0cLXdDCOLKZZUoHc4LnXf2o7ZjDpkhWq0igUw82kFoieqmaHozh0ED+0fvcARER708r2irsDy7CweErUSc7XjYLGP9I\\\\\\\\\\\\\\\/BZYLeWT08bAXFu1nhuNGhEh7wvGtOspeNbBo+BY0CO0VhMPoXSL1tFtR2DnM+JmtIDDjt+TohNIn90Vo6X1og9kMf0O\\\\\\\\\\\\\\\/vQ2JzYP9yQ0l1GVVRGeL5QG1GfBSs2DklIA\\\\\\\\\\\\\\\/TpbMZM3PSvsKES\\\\\\\\\\\\\\\/sO9Ior2hQF4TFXyzUXclQHaXmb2k+NnqYd8oliQgB86hZWpwSVizFU\\\\\\\\\\\\\\\/7S4vmZ3Bd+2Dy\\\\\\\\\\\\\\\/LxQpm8wMcM3ZMRbWMVZvmy+KUiOHjmRbMkyDAuaHR3ek3rCPJJ\\\\\\\\\\\\\\\/Dggx2NDnKwMI4hdR+dH2\\\\\\\\\\\\\\\/E0hAjjcq3uzO1uzbH+3UiLaRr3705yveprc1BCD3Q\\\\\\\\\\\\\\\/0GU3O+lCqhKVxa7ZJVzY6Y5Ar4lR7uYZOx4\\\\\\\\\\\\\\\/hY6DZyD04LArsByBZAYKlDLAq6FzMzhT7sCs6lHies9sP5x2dnpmhrhWdZXNhyjBQG4ZZfcr92SI1GQeYlsUmw3GBAhLLqEqB6xRlAs1q+QEQoSG27c\\\\\\\\\\\\\\\/6DUDR1h0bZEi1YU\\\\\\\\\\\\\\\/0Yelh5gOOnvboeShaSgLiGPfyqAX6QsmZ\\\\\\\\\\\\\\\/epqkK0EiVhj7RJLe3uc4dXyBBSCZ9KvNi5YR0WITqnZbfV9+B+Iktie7tJUAf0JsBqvgGEjvoQtRYdJZKGMeJ61BBLCxr1dNaR9\\\\\\\\\\\\\\\/2u2O1q7mmJ4issQdexHVAxt5+LJyCZOTIdkvO43rrwq30YRKUszOqIcHazUbmaiFKS5la44aKXhpnOEiMDjazgf3Fzt9Uz6eDh5pw31qvE+QwXO9vxSTgq50SrIdV5JbiBtzPdIhSIlPWzKvKbQ0IY=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022h3fFN4bULe8jNDnGcKcPnA==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u00221df42d0159cdaad2d998322534fec3538cda6a8b9b350638d5609561a4867999\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e002752.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e002752.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-002752\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-002752\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-002752\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}