{"markup":"\u003C!DOCTYPE html PUBLIC \u0022-\/\/W3C\/\/DTD HTML 4.0 Transitional\/\/EN\u0022 \u0022http:\/\/www.w3.org\/TR\/REC-html40\/loose.dtd\u0022\u003E\n\u003C?xml version=\u00221.0\u0022 encoding=\u0022UTF-8\u0022 ?\u003E\u003Chtml version=\u0022HTML+RDFa+MathML 1.1\u0022 content=\u0022http:\/\/purl.org\/rss\/1.0\/modules\/content\/\u0022 dc=\u0022http:\/\/purl.org\/dc\/terms\/\u0022 foaf=\u0022http:\/\/xmlns.com\/foaf\/0.1\/\u0022 og=\u0022http:\/\/ogp.me\/ns#\u0022 rdfs=\u0022http:\/\/www.w3.org\/2000\/01\/rdf-schema#\u0022 sioc=\u0022http:\/\/rdfs.org\/sioc\/ns#\u0022 sioct=\u0022http:\/\/rdfs.org\/sioc\/types#\u0022 skos=\u0022http:\/\/www.w3.org\/2004\/02\/skos\/core#\u0022 xsd=\u0022http:\/\/www.w3.org\/2001\/XMLSchema#\u0022 mml=\u0022http:\/\/www.w3.org\/1998\/Math\/MathML\u0022\u003E\u003Chead\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\ngoogletag.slots[\u0022mpu\u0022] = googletag.defineSlot(\u0022\/21798771943\/JITC-MPU\u0022, [[300, 250], [300, 600], [300, 300], [600, 500]], \u0022dfp-ad-mpu\u0022)\n  .addService(googletag.pubads());\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022https:\/\/d1bxh8uas1mnw7.cloudfront.net\/assets\/embed.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022 src=\u0022http:\/\/www.highwirestage.com\/sites\/default\/files\/js\/js_U2pncm4Q4A7IJl4J_deoOoy8h9tU-3gxfOF4iwZdk_g.js\u0022\u003E\u003C\/script\u003E\u003Cscript type=\u0022text\/javascript\u0022\u003E\n\u003C!--\/\/--\u003E\u003C![CDATA[\/\/\u003E\u003C!--\njQuery.extend(Drupal.settings, {\u0022basePath\u0022:\u0022\\\/\u0022,\u0022pathPrefix\u0022:\u0022\u0022,\u0022panels_ajax_pane\u0022:{\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022:\u0022{\\u0022encrypted\\u0022:\\u0022{\\\\\\u0022encrypted\\\\\\u0022:\\\\\\u0022owZE3cyih2EJaQK3TEdp3wi1BQdgF8Wj\\\\\\\\\\\\\\\/4oQTGcG13GYP8kNfXDWroEzSTJHbzRcC5Svho9DyHFbXv9OHh+4ttH8+EMV3gVU2btq\\\\\\\\\\\\\\\/nibm2lWl3kx6s1ZrYd4UkRdkVtALvPGVPBas2xKagtMnUnfWzr9qIAOLxJ8Gt9ta7TNwJv872R\\\\\\\\\\\\\\\/zEJZVSHlerB5tM5pqKyMHhHMnx5bvvb+elWnpp0sffnbY1v\\\\\\\\\\\\\\\/54KV5iD\\\\\\\\\\\\\\\/NaNybY783zRv\\\\\\\\\\\\\\\/VCCtrd49znB6wQBvASlFrsNxcphbgTNfRMur6eiO670VwNwu35NIr3HYZFjRBKeBduFT5miAIyMPskUhRh6C0gccbrDatUZFVTWKHmjzyoVvvIbFgdeFJtn3AOrIqP35TNzywIHwlzmQIMuVd0851rl\\\\\\\\\\\\\\\/mhhfwN6pVhWQKKRvPzMYqTilDKOq0I7\\\\\\\\\\\\\\\/dfefcHf6ZJov9NH\\\\\\\\\\\\\\\/cqCfGZpEz+G8PCxp9AgqCpqWmCWK4LG2gR\\\\\\\\\\\\\\\/KY2rZsd82ZWICxFezDqJtl4bgtGZXTssogShF5xuLTw2auwovxN4elApz1IEQzFWpiw8+TFqS6xc96nbqTlBFypDZasWoT7QNEsCq6mUDToMW8Olo4WfK4GsExZtIkKTcFzmIXo1qPvci1RD3NMm+srCGbjxRtHGjgGkgAbRJybWDU2oKzq5KxRmdUttn17cj6nPdhmEbEHTGW2C9+pqt\\\\\\\\\\\\\\\/KzkDWlVCqZma2iqvPlOMTTIZnCf+ZfELiVLczO+UitRyYRQCDsIkcCJSvmqABfjlpOJuvXxUBj9BV5xm75qNuCH8SgXPGZuw4UvotgZMpr4GJbkHWYuUFEWR5aLzIIjwVNz7imRwLaz2W3F170duR1Ampn11PkZbdbA0upRFJBmaXH+g6xu4aAW\\\\\\\\\\\\\\\/Z4COAgpyp111u6eHmCFFtmW2leCEeOTbM2ExlHNiE\\\\\\\\\\\\\\\/5sn8eFgEvchxDNBPskkUjscD80lm5dnxl0mFBhjYHrHdfPhSLgJtaNA8S9Fy7xFbfVjyDs2uAgrvSwvaXbifRyG4D0teEhluoU0Nnv40gDJEAGbgixiEuWT460Il6nL2OM\\\\\\\\\\\\\\\/1U9sF3ppaxt6+rW3eYsxZ5HUmUZM4w6e6mjeVVzsgRMiC5j1ROYnywvBLfJyl9bhqB\\\\\\\\\\\\\\\/E5hWT2HAt+Rt2YFXWVnq4KLJOjUa9h+BWhmYRbx7jTLsRB7L+zPfhicsWX2kZXpwsUQJP0c\\\\\\\\\\\\\\\/1cRR6LvBYoIKDhMuzcmsJ92Nv8xVgokIFyPwxFUpByZwqnvFE8CYKxKjiPX2CRFBfWHCOSqoxyA6bccwZNXbZ9pCfZ8rwNDYtAibEp+BpkkmBnBq3EE0XusoZaPpsZsCSCu2Os\\\\\\\\\\\\\\\/ilJ+xI7\\\\\\\\\\\\\\\/Jat+jUwaFmZLr6tCGhdNrObDA93BQQrXEndXS31cilBgisIGwamApRzmXHrx+hvt6zeQVrvAJlmknnb4Js8tbKoWUbDrj4sXnLfMviozNa8I1CnbKTCfoAUQW98d2eLofbelqEX3P27ybhnwONspG04uxyise7xDkNKYWrMXNET35nPuauJlofrhdTmDW85AIWLfp8BZctoPGQTK0qALHkFayZAPlsumVwJxGWN2j1JCcT9Ym62WPPTCfM2+7\\\\\\\\\\\\\\\/1AhAHKDmt\\\\\\\\\\\\\\\/ygWAMMz6MtGjvvV6OpzgN4nhAiWVG9JL6xtDNB38kE0ZOyWlwiHCwXHueOY36JGKZmYNvyWr2Muf5AKsckUm554LohYrPmZKclNJD49faxU4bx2rbkowYF\\\\\\\\\\\\\\\/1mBPUvXIB7OrjCU68ebCQKpozpZ3IzSTY3vac6bYtfsrbpjSZXj4l736caGGREGHTyGqRH63oh3zROCaLxfbDlbeaNy9oWcCuGwgttyIqdXh3Lro2OpyBDpGnx8DYj+zBUQPk2\\\\\\\\\\\\\\\/Avi48s9viIJ3\\\\\\\\\\\\\\\/VcRuI\\\\\\\\\\\\\\\/cpGPh+tSz6F05+Q9ADSgVybFLYdZjzfuarGnX9rt8i6DWrcfP4kwC1Sa2zW4\\\\\\\\\\\\\\\/JHOfz7Vtqc1h3aAtcG6jAZD8RFDgmLma0DjWHj0TvIsHGeDZdDU+0Hith4h0g1ujF9jCvzNHUYohmAsHT77g+Cviv5hqyoNAnp6ZElB8OD5kAWN94txmSeCEXP6WDTBgY+az0zzYRit7U2Nd+KfIPlVnkgG4qCBvQNnwgsbt+OlOw8MX\\\\\\\\\\\\\\\/VzlZD\\\\\\\\\\\\\\\/Rka3rGmeswqO7JAvqUY7devWO5t0rNWJcBn4kUJCxYKc6uc45Wnp84b3l14lCqtYJZ5nZD4hYpsB2ntoxkCtpkDi\\\\\\\\\\\\\\\/Yx+TndbFvVEXKgh9w7STz+EDtbA\\\\\\\\\\\\\\\/kPgy++7M3nObIRRjvX\\\\\\\\\\\\\\\/R6Y9jQUgmGD4H94BVtt45Y7beUGrTeXySAbVI8yR9ckVOs4mEQkKOMBJS3X+mEs3PMXrjpWYQYtz50AVM7x1NzK8VvYGAf0VA\\\\\\\\\\\\\\\/MN1FtEM27JOiLzeDB6YVr8gzcE5A6DFH2vz29UzqxT2vsRmoszb44M\\\\\\\\\\\\\\\/I7OnkdL3Uv\\\\\\\\\\\\\\\/P6knufj6AyLxlTx4s1gTt\\\\\\\\\\\\\\\/\\\\\\\\\\\\\\\/zqQyoIZFEwjHUsp1big+UUEF+eU4pD86IgiPvG4bp67BNI6tdiulYkLbOyb5YJ21fyoj48uXqE+HdyKEtVqqWbxLQbh\\\\\\\\\\\\\\\/MSx0gFJPWfS5BfOV2GrnQkVm20DpDPQ5Xv14w++RKpy+JkXYoil3MURwYmKt78rITEO+4dE7Co=\\\\\\u0022,\\\\\\u0022iv\\\\\\u0022:\\\\\\u0022ox\\\\\\\\\\\\\\\/LIGvn97o+zvr37IuzKw==\\\\\\u0022,\\\\\\u0022salt\\\\\\u0022:\\\\\\u00223fcf69c0544933648ca27e63b3137e55\\\\\\u0022}\\u0022,\\u0022hmac\\u0022:\\u002288d8d277abd0ac1a9632a9fdc20f50acb4e738f4cee0335590bedea048c62b85\\u0022}\u0022},\u0022highwire\u0022:{\u0022ac\u0022:{\u0022\\\/jitc\\\/9\\\/8\\\/e003220.atom\u0022:{\u0022access\u0022:{\u0022full\u0022:true,\u0022abstract\u0022:true},\u0022pisa_id\u0022:\u0022\u0022,\u0022apath\u0022:\u0022\\\/jitc\\\/9\\\/8\\\/e003220.atom\u0022,\u0022jcode\u0022:\u0022jitc\u0022}}},\u0022MutationObserver\u0022:{\u0022js\u0022:\u0022\\\/sites\\\/all\\\/libraries\\\/mutationobserver\\\/MutationObserver.js\u0022},\u0022ajaxPageState\u0022:{\u0022js\u0022:{\u00220\u0022:1,\u0022https:\\\/\\\/d1bxh8uas1mnw7.cloudfront.net\\\/assets\\\/embed.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/highwire\\\/highwire\\\/plugins\\\/content_types\\\/js\\\/highwire_altmetrics.js\u0022:1,\u0022sites\\\/all\\\/modules\\\/contrib\\\/panels_ajax_pane\\\/panels_ajax_pane.js\u0022:1}}});\n\/\/--\u003E\u003C!]]\u003E\n\u003C\/script\u003E\u003Clink type=\u0022text\/css\u0022 rel=\u0022stylesheet\u0022 href=\u0022\/\/www.highwirestage.com\/sites\/default\/files\/advagg_css\/css__dn-cpI1YtkU_iLHgA5WhlkxgYWyat_IxjF_B-WSYrpE__a9hIbt0eaZ7d5nhwnm2weG8R_2eXK4EvoOx9dOxouHE__3qvfz4I9k5oUIeimOjbmdyh6ZgM-xweyVc5gub1_nR4.css\u0022 media=\u0022all\u0022\u003E\u003Clink rel=\u0022stylesheet\u0022 type=\u0022text\/css\u0022 href=\u0022\/sites\/all\/modules\/contrib\/panels\/plugins\/layouts\/onecol\/onecol.css\u0022\u003E\u003C\/head\u003E\u003Cbody\u003E\u003Cdiv class=\u0022panels-ajax-tab-panel panels-ajax-tab-panel-jnl-template-bmjj-tab-art\u0022\u003E\u003Cdiv class=\u0022panel-display panel-1col clearfix\u0022\u003E\n  \u003Cdiv class=\u0022panel-panel panel-col\u0022\u003E\n    \u003Cdiv\u003E\u003Cdiv class=\u0022panel-pane pane-dfp-pane oas-ads oas-ads-mid pull-right\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv id=\u0022dfp-ad-mpu-wrapper\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n\n\u003Cdiv id=\u0022dfp-ad-mpu\u0022 class=\u0022dfp-tag-wrapper\u0022\u003E\n  \u003Cscript type=\u0022text\/javascript\u0022\u003E\n    googletag.cmd.push(function() {\n      googletag.display(\u0022dfp-ad-mpu\u0022);\n    });\n  \u003C\/script\u003E\u003C\/div\u003E\n\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-1\u0022\u003E\n  \n      \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003E\u003Ca href=\u0022https:\/\/doi.org\/10.1136\/jitc-2021-003220\u0022 target=\u0022_new\u0022\u003Ehttps:\/\/doi.org\/10.1136\/jitc-2021-003220\u003C\/a\u003E\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-altmetrics\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003EStatistics from Altmetric.com\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv data-badge-details=\u0022right\u0022 data-badge-type=\u0022medium-donut\u0022 data-doi=\u002210.1136\/jitc-2021-003220\u0022 data-hide-no-mentions=\u0022true\u0022 class=\u0022altmetric-embed\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-custom pane-2 permissions-box\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ERequest Permissions\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cp\u003EIf you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center\u0026rsquo;s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.\u003C\/p\u003E\n  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-panels-ajax-pane-content permissions-box pane-highwire-permission-link\u0022 id=\u0022request-permissions\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003E\u003Cspan class=\u0022panels-ajax-pane-title\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/span\u003E\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022panels-ajax-pane panels-ajax-pane-new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022 data-pid=\u0022new-70fd4c70-563e-4b94-ae3b-2a97f3980c13\u0022\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003Cdiv class=\u0022panel-separator\u0022\u003E\u003C\/div\u003E\u003Cdiv class=\u0022panel-pane pane-highwire-article-data-supp\u0022 id=\u0022supplementary-materials\u0022\u003E\n  \n        \u003Ch2 class=\u0022pane-title\u0022\u003ESupplementary materials\u003C\/h2\u003E\n    \n  \n  \u003Cdiv class=\u0022pane-content\u0022\u003E\n    \u003Cdiv class=\u0022item-list\u0022\u003E\u003Cul\u003E\u003Cli class=\u0022first last\u0022\u003E\n\u003C\/ul\u003E\u003C\/div\u003E  \u003C\/div\u003E\n\n  \n  \u003C\/div\u003E\n\u003C\/div\u003E\n  \u003C\/div\u003E\n\u003C\/div\u003E\n\u003C\/div\u003E\u003C\/body\u003E\u003C\/html\u003E\n"}